ArticleSocial neuroscience2017
Selective localization of oxytocin receptors and vasopressin 1a receptors in the human brainstem.
Article in Social neuroscience, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 1 of them a synthesis that pooled it.
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Who cites it
30 citing papers in PubMed, 1 synthesis or guideline pooled it, 49 citations in OpenAlex.
- Intranasal Oxytocin May Improve High-Level Social Cognition in Schizophrenia, But Not Social Cognition or Neurocognition in General: A Multilevel Bayesian Meta-analysis.Schizophrenia bulletin · 2017Pooled it
- Oxytocin receptor antagonism in migraine: a randomized, double-blind, placebo-controlled provocation study.The journal of headache and pain · 2026Trial
- Oxytocin Reduces Alcohol Cue-Reactivity in Alcohol-Dependent Rats and Humans.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2018Trial
- The dual role of arginine vasopressin in immune regulation: Balancing immunostimulation and immunosuppression.Brain, behavior, & immunity - health · 2026Review
- A holistic review of fatherhood in humans and non-human animals: mechanisms of fatherhood, effects on fathers themselves, and interactions of fathers with others.Frontiers in behavioral neuroscience · 2026Review
- The Oxytocin System and Implications for Oxytocin Deficiency in Hypothalamic-Pituitary Disease.Endocrine reviews · 2025Review
- Hypothalamic Paraventricular Stimulation Inhibits Nociceptive Wide Dynamic Range Trigeminocervical Complex Cells via Oxytocinergic Transmission.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Review
- Effect of sex and autism spectrum disorder on oxytocin receptor binding and mRNA expression in the dopaminergic pars compacta of the human substantia nigra.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2022Article
- Oxytocin and testosterone administration amplify viewing preferences for sexual images in male rhesus macaques.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2022Article
- Complementary Role of Oxytocin and Vasopressin in Cardiovascular Regulation.International journal of molecular sciences · 2021Review
- Convergent neuroendocrine mechanisms of social buffering and stress contagion.Hormones and behavior · 2021Review
- Neural correlates of mating system diversity: oxytocin and vasopressin receptor distributions in monogamous and non-monogamous Eulemur.Scientific reports · 2021Article
- Developing Brain Glucose Transporters, Serotonin, Serotonin Transporter, and Oxytocin Receptor Expression in Response to Early-Life Hypocaloric and Hypercaloric Dietary, and Air Pollutant Exposures.Developmental neuroscience · 2021Article
- Oxytocin receptor binding in the titi monkey hippocampal formation is associated with parental status and partner affiliation.Scientific reports · 2020Article
- Hypothalamic Neuropeptide Brain Protection: Focus on Oxytocin.Journal of clinical medicine · 2020Review
- The human hypothalamus in mood disorders: The HPA axis in the center.IBRO reports · 2019Review
- Effect of age and autism spectrum disorder on oxytocin receptor density in the human basal forebrain and midbrain.Translational psychiatry · 2018Article
- Effects of Chronic Oxytocin Administration and Diet Composition on Oxytocin and Vasopressin 1a Receptor Binding in the Rat Brain.Neuroscience · 2018Article
- Oxytocin receptor mRNA expression in dorsolateral prefrontal cortex in major psychiatric disorders: A human post-mortem study.Psychoneuroendocrinology · 2018Article
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Intranasal oxytocin (OT) affects a suite of human social behaviors, including trust, eye contact, and emotion recognition. However, it is unclear where oxytocin receptors (OXTR) and the structurally related vasopressin 1a receptors (AVPR1a) are expressed in the human brain. We have previously described a reliable, pharmacologically informed receptor autoradiography protocol for visualizing these receptors in postmortem primate brain tissue. We used this technique in human brainstem tissue to identify the neural targets of OT and vasopressin. To determine binding selectivity of the OXTR radioligand and AVPR1a radioligand, sections were incubated in four conditions: radioligand alone, radioligand with the selective AVPR1a competitor SR49059, and radioligand with a low or high concentration of the selective OXTR competitor ALS-II-69. We found selective OXTR binding in the spinal trigeminal nucleus, a conserved region of OXTR expression in all primate species investigated to date. We found selective AVPR1a binding in the nucleus prepositus, an area implicated in eye gaze stabilization. The tissue's postmortem interval (PMI) was not correlated with either the specific or nonspecific binding of either radioligand, indicating that it will not likely be a factor in similar postmortem studies. This study provides critical data for future studies of OXTR and AVPR1a in human brain tissue.
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Registered trials
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