Evidence map›Paper›PMID 26911382›Full record

ArticlePsychopharmacology2016

Impulsivity in abstinent alcohol and polydrug dependence: a multidimensional approach.

Eleanor M Taylor, Anna Murphy, Venkat Boyapati, Karen D Ersche, Remy Flechais, Shankar Kuchibatla, John McGonigle, Anotonio Metastasio, Liam Nestor, Csaba Orban and 11 more

Open access · hybridAbstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Psychopharmacology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
3.2field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it, 34 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Trial
  4. Review
  5. Alcohol and the Brain.Nutrients · 2021
    Review
  6. Article
  7. Article
  8. Differences in decision-making as a function of drug of choice.Pharmacology, biochemistry, and behavior · 2018
    Review
  9. Article
  10. Acute D3 Antagonist GSK598809 Selectively Enhances Neural Response During Monetary Reward Anticipation in Drug and Alcohol Dependence.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2017
    Article
  11. Altered reward expectancy in individuals with recent methamphetamine dependence.Journal of psychopharmacology (Oxford, England) · 2017
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors at 4 institutions in 1 country.

Eleanor M TaylorNeuroscience and Psychiatry Unit, Institute of Brain Behaviour and Mental Health, University of Manchester, Manchester, UK. eleanor.taylor-2@manchester.ac.uk.ORCID http://orcid.org/0000-0001-5793-1621
Anna MurphyNeuroscience and Psychiatry Unit, Institute of Brain Behaviour and Mental Health, University of Manchester, Manchester, UK.
Venkat BoyapatiNeuroscience and Psychiatry Unit, Institute of Brain Behaviour and Mental Health, University of Manchester, Manchester, UK.
Karen D ErscheBehavioural and Clinical Neuroscience Institute, University of Cambridge, Cambridge, UK.
Remy FlechaisCentre for Neuropsychopharmacology, Division of Brain Sciences, Imperial College London, London, UK.
Shankar KuchibatlaNeuroscience and Psychiatry Unit, Institute of Brain Behaviour and Mental Health, University of Manchester, Manchester, UK.
John McGonigleCentre for Neuropsychopharmacology, Division of Brain Sciences, Imperial College London, London, UK.
Anotonio MetastasioNeuroscience and Psychiatry Unit, Institute of Brain Behaviour and Mental Health, University of Manchester, Manchester, UK.
Liam NestorCentre for Neuropsychopharmacology, Division of Brain Sciences, Imperial College London, London, UK.
Csaba OrbanCentre for Neuropsychopharmacology, Division of Brain Sciences, Imperial College London, London, UK.
Fillippo PassettiBehavioural and Clinical Neuroscience Institute, University of Cambridge, Cambridge, UK.
Louise PatersonCentre for Neuropsychopharmacology, Division of Brain Sciences, Imperial College London, London, UK.
Dana SmithBehavioural and Clinical Neuroscience Institute, University of Cambridge, Cambridge, UK.
John SucklingBehavioural and Clinical Neuroscience Institute, University of Cambridge, Cambridge, UK.
Roger TaitBehavioural and Clinical Neuroscience Institute, University of Cambridge, Cambridge, UK.
Anne R Lingford-HughesCentre for Neuropsychopharmacology, Division of Brain Sciences, Imperial College London, London, UK.
Trevor W RobbinsBehavioural and Clinical Neuroscience Institute, University of Cambridge, Cambridge, UK.
David J NuttCentre for Neuropsychopharmacology, Division of Brain Sciences, Imperial College London, London, UK.
J F William DeakinNeuroscience and Psychiatry Unit, Institute of Brain Behaviour and Mental Health, University of Manchester, Manchester, UK.
Rebecca ElliottNeuroscience and Psychiatry Unit, Institute of Brain Behaviour and Mental Health, University of Manchester, Manchester, UK.
ICCAM Platform
University of Cambridge · GBUniversity of Manchester · GBGlaxoSmithKline (United Kingdom) · GBManchester Academic Health Science Centre · GB

Funding

Medical Research Council G1000018Wellcome Trust
6 · The paper itself

Abstract

rationaleDependence on drugs and alcohol is associated with impaired impulse control, but deficits are rarely compared across individuals dependent on different substances using several measures within a single study.

objectivesWe investigated impulsivity in abstinent substance-dependent individuals (AbD) using three complementary techniques: self-report, neuropsychological and neuroimaging. We hypothesised that AbDs would show increased impulsivity across modalities, and that this would depend on length of abstinence.

methodsData were collected from the ICCAM study: 57 control and 86 AbDs, comprising a group with a history of dependence on alcohol only (n = 27) and a group with history of dependence on multiple substances ("polydrug", n = 59). All participants completed self-report measures of impulsivity: Barratt Impulsiveness Scale, UPPS Impulsive Behaviour Scale, Behaviour Inhibition/Activation System and Obsessive-Compulsive Inventory. They also performed three behavioural tasks: Stop Signal, Intra-Extra Dimensional Set-Shift and Kirby Delay Discounting; and completed a Go/NoGo task during fMRI.

resultsAbDs scored significantly higher than controls on self-report measures, but alcohol and polydrug dependent groups did not differ significantly from each other. Polydrug participants had significantly higher discounting scores than both controls and alcohol participants. There were no group differences on the other behavioural measures or on the fMRI measure.

conclusionsThe results suggest that the current set of self-report measures of impulsivity is more sensitive in abstinent individuals than the behavioural or fMRI measures of neuronal activity. This highlights the importance of developing behavioural measures to assess different, more relevant, aspects of impulsivity alongside corresponding cognitive challenges for fMRI.

Indexed as

Impulsive BehaviorReaction TimeSelf ReportAdultAgedAlcohol AbstinenceCohort StudiesFemaleHumansInhibition, PsychologicalMagnetic Resonance ImagingMaleMiddle AgedSubstance-Related DisordersYoung AdultAddictionAlcoholCognitionDrug AbuseFMRI

Identifiers

PMID26911382
PMCPMC4819593
OpenAlexW2278242581

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.