ArticleBMC medical imaging2016
Correlation between degenerative spine disease and bone marrow density: a retrospective investigation.
Article in BMC medical imaging, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Bone Mineral Density of Spine Patients with CT Hounsfield Units and AI Segmentation: A Contemporary Review.Asian journal of neurosurgery · 2026Review
- Trabecular texture and paraspinal muscle characteristics for prediction of first vertebral fracture: a QCT analysis from the AGES cohort.Frontiers in endocrinology · 2025Article
- Correlation Between Bone Mineral Density And Different Types of Modic Changes in Lumbar Spine.Current medical imaging · 2025Article
- Exploring Causality Between Bone Mineral Density and Cervical Spondylosis: Bidirectional and Multivariable Mendelian Randomization Study.Journal of pain research · 2025Article
- Prevalence of Osteoporosis and Sarcopenia in Middle-Aged Subjects with Low Back Pain.The Indian journal of radiology & imaging · 2025Article
- Evaluation of deep learning-based quantitative computed tomography for opportunistic osteoporosis screening.Scientific reports · 2024Article
- Disc degeneration influences the strain magnitude and stress distribution within the adjacent trabecular bone.Frontiers in bioengineering and biotechnology · 2024Article
- Artificial Intelligence Applications for Osteoporosis Classification Using Computed Tomography.Bioengineering (Basel, Switzerland) · 2023Review
- Association between lumbar endplate damage and bone mineral density in patients with degenerative disc disease.BMC musculoskeletal disorders · 2023Article
- Fatty Degeneration of the Autochthonous Muscles Is Significantly Associated with Incidental Non-Traumatic Vertebral Body Fractures of the Lower Thoracic Spine in Elderly Patients.Journal of clinical medicine · 2023Article
- The association of lumbar disc degeneration with lumbar vertebral trabecular volumetric bone mineral density in an urban population of young and middle-aged community-dwelling Chinese adults: a cross-sectional study.Journal of bone and mineral metabolism · 2023Article
- Total body bone mineral density and various spinal disorders: a Mendelian randomization study.Frontiers in endocrinology · 2023Article
- Osteoporosis and Endplate Damage Correlation Using a Combined Approach of Hounsfield Unit Values and Total Endplate Scores: A Retrospective Cross-Sectional Study.Clinical interventions in aging · 2021Article
- Peripheral DXA measurement around ankle joint to diagnose osteoporosis as assessed by central DXA measurement.Skeletal radiology · 2018Article
- Evaluation of shared genetic aetiology between osteoarthritis and bone mineral density identifies SMAD3 as a novel osteoarthritis risk locus.Human molecular genetics · 2017Article
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSpondylosis leads to an overestimation of bone mineral density (BMD) with dual-energy x-ray absorptiometry (DXA) but not with quantitative computed tomography (QCT). The correlation between degenerative changes of the spine and QCT-BMD was therefore investigated for the first time.
methodsOne hundred thirty-four patients (66 female and 68 male) with a mean age of 49.0 ± 14.6 years (range: 19-88 years) who received a CT scan and QCT-BMD measurements of spine and hip were evaluated retrospectively. The occurrence and severity of spondylosis, osteochondrosis, and spondylarthrosis and the height of the vertebral bodies were assessed.
resultsA negative correlation was found between spinal BMD and number of spondylophytes (ρ = -0.35; p < 0.01), disc heights (r = -0.33; p < 0.01), number of discal air inclusions (ρ = -0.34; p < 0.01), the number of Schmorl nodules (ρ = -0.25; p < 0.01), the number (ρ = -0.219; p < 0.05) and the degree (ρ = -0.220; p < 0.05) of spondylarthrosis. Spinal and hip BMD correlated moderately, but the latter did not correlate with degenerative changes of the spine. In linear regression models age, osteochondrosis and spondylarthrosis were factors influencing spinal BMD.
conclusionDegenerative spinal changes may be associated with reduced regional spinal mineralization. This knowledge could lead to a modification of treatment of degenerative spine disease with early treatment of osteopenia to prevent secondary fractures.
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