ArticleScientific reports2016
Imaging trace element distributions in single organelles and subcellular features.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed.
- A comparative study to assess the use of chromium in type 2 diabetes mellitus.Journal of medicine and life · 2023Trial
- Correlative imaging reveals metal dyshomeostasis and altered zinc coordination environments in a pre-clinical Type 2 diabetes model.Metallomics : integrated biometal science · 2026Article
- X-ray Fluorescence Microscopy to Develop Elemental Classifiers and Investigate Elemental Signatures in BALB/c Mouse Intestine a Week after Exposure to 8 Gy of Gamma Rays.International journal of molecular sciences · 2024Article
- Diabetic Neuropathy of the Retina and Inflammation: Perspectives.International journal of molecular sciences · 2023Review
- The use of synchrotron X-ray fluorescent imaging to study distribution and content of elements in chemically fixed single cells: a case study using mouse pancreatic beta-cells.Metallomics : integrated biometal science · 2023Article
- Sensitive fluorescent chemosensor for Hg(II) in aqueous solution using 4'-dimethylaminochalcone.Journal of fluorescence · 2022Article
- Mitochondrial iron metabolism and neurodegenerative diseases.Neurotoxicology · 2022Review
- Zinc Signaling in the Mammary Gland: For Better and for Worse.Biomedicines · 2021Review
- Arabidopsis bZIP19 and bZIP23 act as zinc sensors to control plant zinc status.Nature plants · 2021Article
- The Role of Transient Receptor Potential A1 and G Protein-Coupled Receptor 39 in Zinc-Mediated Acute and Chronic Itch in Mice.Frontiers in molecular neuroscience · 2021Article
- Pancreatic Islets Accumulate Cadmium in a Rodent Model of Cadmium-Induced Hyperglycemia.International journal of molecular sciences · 2020Article
- Nano-imaging trace elements at organelle levels in substantia nigra overexpressing α-synuclein to model Parkinson's disease.Communications biology · 2020Article
- Review
- X-ray Fluorescence Nanotomography of Single Bacteria with a Sub-15 nm Beam.Scientific reports · 2018Article
- Synthesis and Postpolymerization Modification of Fluorine-End-Labeled Poly(Pentafluorophenyl Methacrylate) Obtained via RAFT Polymerization.ACS omega · 2018Article
- Preserving elemental content in adherent mammalian cells for analysis by synchrotron-based x-ray fluorescence microscopy.Journal of microscopy · 2017Article
- The emerging role of zinc transporters in cellular homeostasis and cancer.Signal transduction and targeted therapyArticle
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
The distributions of chemical elements within cells are of prime importance in a wide range of basic and applied biochemical research. An example is the role of the subcellular Zn distribution in Zn homeostasis in insulin producing pancreatic beta cells and the development of type 2 diabetes mellitus. We combined transmission electron microscopy with micro- and nano-synchrotron X-ray fluorescence to image unequivocally for the first time, to the best of our knowledge, the natural elemental distributions, including those of trace elements, in single organelles and other subcellular features. Detected elements include Cl, K, Ca, Co, Ni, Cu, Zn and Cd (which some cells were supplemented with). Cell samples were prepared by a technique that minimally affects the natural elemental concentrations and distributions, and without using fluorescent indicators. It could likely be applied to all cell types and provide new biochemical insights at the single organelle level not available from organelle population level studies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.