Evidence map›Paper›PMID 26910583›Full record

ArticleMuscle & nerve2016

Trends in steroid therapy for Duchenne muscular dystrophy in Japan.

Fumi Takeuchi, Hirofumi Komaki, Harumasa Nakamura, Naohiro Yonemoto, Kousuke Kashiwabara, En Kimura, Shin'ichi Takeda

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Muscle & nerve, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 8 citations in OpenAlex.

  1. Viltolarsen in Japanese Duchenne muscular dystrophy patients: A phase 1/2 study.Annals of clinical and translational neurology · 2020
    Trial
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 3 countries.

Fumi TakeuchiDepartment of Clinical Research Support, Translational Medical Center, National Center of Neurology and Psychiatry, Tokyo, Japan.
Hirofumi KomakiDepartment of Child Neurology, National Center of Neurology and Psychiatry 4-1-1 Ogawa-higashi, Kodaira, Tokyo, 187-8551, Japan. komakih@ncnp.go.jp.
Harumasa NakamuraDepartment of Clinical Research Support, Translational Medical Center, National Center of Neurology and Psychiatry, Tokyo, Japan.
Naohiro YonemotoDepartment of Neuropsychopharmacology, National Institute of Mental Health, National Center of Neurology and Psychiatry, Tokyo, Japan.
Kousuke KashiwabaraDepartment of Clinical Epidemiology, Translational Medical Center, National Center of Neurology and Psychiatry, Tokyo, Japan.
En KimuraDepartment of Clinical Research Support, Translational Medical Center, National Center of Neurology and Psychiatry, Tokyo, Japan.
Shin'ichi TakedaDepartment of Molecular Therapy, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Tokyo, Japan.
National Center of Neurology and Psychiatry · JPNational Medical Research Center of Cardiology · RU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionWe conducted a study to reveal trends in steroid prescription for Duchenne muscular dystrophy (DMD) patients in Japan.

methodsWe asked patients (ages 5-20 years) identified in the patient registry and their clinicians about steroid therapy experiences. Regimen, dose, and starting age were compared among 3 subgroups according to prednisolone initiation year (2000-2004, 2005-2009, and 2010-2013).

resultsAmong 157 prednisolone users, 4 different regimens were used. Dose frequencies were: every other day (98 patients), daily (44 patients), 10 days on 20 days off (14 patients), and weekly (1 patient). Median starting age was 6 years, and median dose was 0.42 mg/kg/day. There was an increase in daily regimen use from 2005-2009 (n = 9, 16%) to 2010-2013 (n = 33, 36%).

conclusionsThis study revealed a transition over time in steroid use from expert opinion to evidence-based recommendation. Clinical research should be encouraged to optimize medication worldwide. Muscle Nerve 54: 673-680, 2016.

Indexed as

AdolescentChildChild, PreschoolCohort StudiesFemaleGlucocorticoidsHumansJapanMaleMuscular Dystrophy, DuchennePrednisoloneSurveys and QuestionnairesYoung AdultGlucocorticoidsPrednisoloneclinical researchDuchenne muscular dystrophyexpert opinionguidelinepatient registryregimensteroid therapy

Identifiers

PMID26910583
PMCPMC5113709
OpenAlexW2284182913

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.