ArticleBiophysical journal2016
Feedback Regulation and Time Hierarchy of Oxidative Phosphorylation in Cardiac Mitochondria.
Article in Biophysical journal, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 30 citations in OpenAlex.
- A simulation study on the role of mitochondria-sarcoplasmic reticulum CaThe Journal of physiology · 2025Article
- Postnatal growth restriction alters myocardial mitochondrial energetics in mice.Experimental physiology · 2024Article
- Integrated Functions of Cardiac Energetics, Mechanics, and Purine Nucleotide Metabolism.Comprehensive Physiology · 2023Article
- Crosstalk between adenine nucleotide transporter and mitochondrial swelling: experimental and computational approaches.Cell biology and toxicology · 2023Article
- Kinetic Mathematical Modeling of Oxidative Phosphorylation in Cardiomyocyte Mitochondria.Cells · 2022Review
- Substrate-dependent differential regulation of mitochondrial bioenergetics in the heart and kidney cortex and outer medulla.Biochimica et biophysica acta. Bioenergetics · 2022Article
- Article
- Quantitative analysis of mitochondrial ATP synthesis.Mathematical biosciences · 2021Article
- Computationally modeling mammalian succinate dehydrogenase kinetics identifies the origins and primary determinants of ROS production.The Journal of biological chemistry · 2020Article
- Nuclear metabolism and the regulation of the epigenome.Nature metabolism · 2020Review
- Impaired Myocardial Energetics Causes Mechanical Dysfunction in Decompensated Failing Hearts.Function (Oxford, England) · 2020Article
- Cardiac Metabolic Limitations Contribute to Diminished Performance of the Heart in Aging.Biophysical journal · 2019Article
- Skeletal muscle performance in metabolic disease: Microvascular or mitochondrial limitation or both?Microcirculation (New York, N.Y. : 1994) · 2019Review
- Calcium phosphate precipitation inhibits mitochondrial energy metabolism.PLoS computational biology · 2019Article
- Analysis of a Functional Dimer Model of Ubiquinol Cytochrome c Oxidoreductase.Biophysical journal · 2017Article
- Estrogen maintains mitochondrial content and function in the right ventricle of rats with pulmonary hypertension.Physiological reports · 2017Article
- The effect of respiration buffer composition on mitochondrial metabolism and function.PloS one · 2017Article
- Systems biology reveals uncoupling beyond UCP1 in human white fat-derived beige adipocytes.NPJ systems biology and applications · 2017Article
- A simulation study on the constancy of cardiac energy metabolites during workload transition.The Journal of physiology · 2016Article
- Improving the physiological realism of experimental models.Interface focus · 2016Review
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
To determine how oxidative ATP synthesis is regulated in the heart, the responses of cardiac mitochondria oxidizing pyruvate to alterations in [ATP], [ADP], and inorganic phosphate ([Pi]) were characterized over a range of steady-state levels of extramitochondrial [ATP], [ADP], and [Pi]. Evolution of the steady states of the measured variables with the flux of respiration shows that: (1) a higher phosphorylation potential is achieved by mitochondria at higher [Pi] for a given flux of respiration; (2) the time hierarchy of oxidative phosphorylation is given by phosphorylation subsystem, electron transport chain, and substrate dehydrogenation subsystems listed in increasing order of their response times; (3) the matrix ATP hydrolysis mass action ratio [ADP] × [Pi]/[ATP] provides feedback to the substrate dehydrogenation flux over the entire range of respiratory flux examined in this study; and finally, (4) contrary to previous models of regulation of oxidative phosphorylation, [Pi] does not modulate the activity of complex III.
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Registered trials
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