Evidence map›Paper›PMID 26910422›Full record

ArticleBiophysical journal2016

Retrograde Coupling: Muscle's Orphan Signaling Pathway?

Bernhard E Flucher

Open access · bronzeAbstract readComment
PubMed Full text at PMC Publisher
In one paragraph

Article in Biophysical journal, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.3field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

1 author at 1 institution in 1 country.

Bernhard E FlucherDepartment of Physiology and Medical Physics, Medical University Innsbruck, Innsbruck Austria. Electronic address: bernhard.e.flucher@i-med.ac.at.
Innsbruck Medical University · AT

Funding

Austrian Science Fund FWF P 23479Austrian Science Fund FWF P 27031Austrian Science Fund FWF W 1101
6 · The paper itself

Abstract

In skeletal muscle excitation-contraction coupling, a voltage-gated calcium channel directly activates opening of the calcium release channel (RyR1) in the sarcoplasmic reticulum that supplies the calcium signal triggering contraction. In addition, a retrograde signal from the RyR1 facilitates gating of the voltage-gated calcium channel. Recent studies of RyR1 mutants, including the article by Bannister et al. in this issue of the Biophysical Journal, advance our understanding of the signaling mechanism, although the physiological significance of retrograde coupling remains elusive.

Indexed as

AnimalsCalciumCalcium Channels, L-TypeCalcium SignalingExcitation Contraction CouplingHumansMuscle ContractionMuscle, SkeletalRyanodine Receptor Calcium Release ChannelSarcoplasmic ReticulumSignal TransductionCalciumCalcium Channels, L-TypeRyanodine Receptor Calcium Release Channel

Identifiers

PMID26910422
PMCPMC4775872
OpenAlexW2283408679

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.