ArticleMemorias do Instituto Oswaldo Cruz2016
Sensitivity and specificity of parallel or serial serological testing for detection of canine Leishmania infection.
Article in Memorias do Instituto Oswaldo Cruz, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Correlation of serum screening and neuroimaging studies: A comparative analysis for diagnostic evaluation of neurocysticercosis among people with epilepsy attending mental health clinics in selected district hospitals of Tanzania.PLoS neglected tropical diseases · 2025Article
- Finding Priority Areas in the Evaluation of Strategies for the Prevention of Leishmaniasis in an Endemic Municipality of Brazil.Tropical medicine and infectious disease · 2024Article
- Canine Cytokines Profile in an Endemic Region ofVeterinary sciences · 2022Article
- Serial use of existing clinical decisions aids can reduce computed tomography pulmonary angiography for pulmonary embolism.Internal and emergency medicine · 2021Article
- Frequency of detection and load of amastigotes in the pancreas of Leishmania infantum-seropositive dogs: clinical signs and histological changes.Parasites & vectors · 2021Article
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- Leishmania infantum-derived lipophosphoglycan as an antigen in the accurate serodiagnosis of canine leishmaniasis.PLoS neglected tropical diseases · 2019Article
- Dual Unsafe Injection and Sexual Behaviors for HIV Infection Among People Who Inject Drugs in Iran.AIDS and behavior · 2019Article
- Bayesian Assessment of the Accuracy of a PCR-Based Rapid Diagnostic Test for Bovine Tuberculosis in Swine.Frontiers in veterinary science · 2019Article
- Diagnosing risk factors alongside mass drug administration using serial diagnostic tests-which test first?Transactions of the Royal Society of Tropical Medicine and Hygiene · 2018Article
- Accuracy of the Lee-White Clotting Time Performed in the Hospital Routine to Detect Coagulopathy inThe American journal of tropical medicine and hygiene · 2018Article
- Scoring clinical signs can help diagnose canine visceral leishmaniasis in a highly endemic area in Brazil.Memorias do Instituto Oswaldo Cruz · 2017Article
- Symptomatic Leishmaniasis in an Italian Segugio Dog from Northeastern Romania: A Case Report.Iranian journal of parasitologyArticle
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Authors and funding
7 authors.
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No grant is acknowledged in the PubMed record.
Abstract
In Brazil, human and canine visceral leishmaniasis (CVL) caused by Leishmania infantum has undergone urbanisation since 1980, constituting a public health problem, and serological tests are tools of choice for identifying infected dogs. Until recently, the Brazilian zoonoses control program recommended enzyme-linked immunosorbent assays (ELISA) and indirect immunofluorescence assays (IFA) as the screening and confirmatory methods, respectively, for the detection of canine infection. The purpose of this study was to estimate the accuracy of ELISA and IFA in parallel or serial combinations. The reference standard comprised the results of direct visualisation of parasites in histological sections, immunohistochemical test, or isolation of the parasite in culture. Samples from 98 cases and 1,327 noncases were included. Individually, both tests presented sensitivity of 91.8% and 90.8%, and specificity of 83.4 and 53.4%, for the ELISA and IFA, respectively. When tests were used in parallel combination, sensitivity attained 99.2%, while specificity dropped to 44.8%. When used in serial combination (ELISA followed by IFA), decreased sensitivity (83.3%) and increased specificity (92.5%) were observed. Serial testing approach improved specificity with moderate loss in sensitivity. This strategy could partially fulfill the needs of public health and dog owners for a more accurate diagnosis of CVL.
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