Evidence map›Paper›PMID 26909692›Full record

ArticleNeuroradiology2016

Curative embolization of pediatric intracranial arteriovenous malformations using Onyx: the role of new embolization techniques on patient outcomes.

L H de Castro-Afonso, G S Nakiri, R S Oliveira, M V Santos, A C Dos Santos, H R Machado, D G Abud

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In one paragraph

Article in Neuroradiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 2 pooled it
4.9field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 2 syntheses or guidelines pooled it, 53 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Pediatric Brain AVM: The Role of DSA During Surgery in Hybrid Operating Room.Advances and technical standards in neurosurgery · 2026
    Article
  5. Clinical features and outcome in pediatric arteriovenous malformation: institutional multimodality treatment.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2023
    Article
  6. Review
  7. Single-center experience with endovascular treatment of cerebral arteriovenous malformations with intent to cure in pediatric patients.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2022
    Article
  8. Article
  9. Arteriovenous malformation surgery in children: the Rady Children's Hospital experience (2002-2019).Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2021
    Article
  10. Article
  11. Review
  12. Article
  13. Onyx embolization of a ruptured anterior inferior cerebellar artery in a neonate.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2019
    Article
  14. Article
  15. A challenging entity of endovascular embolization with ONYX for brainstem arteriovenous malformation: Experience from 13 cases.Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences · 2017
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

L H de Castro-AfonsoDivision of Interventional Neuroradiology, Medical School of Ribeirão Preto, University of São Paulo, Avenida Bandeirantes, 3900, Monte Alegre, Ribeirão Preto, SP, Brazil, 14048-090.
G S NakiriDivision of Interventional Neuroradiology, Medical School of Ribeirão Preto, University of São Paulo, Avenida Bandeirantes, 3900, Monte Alegre, Ribeirão Preto, SP, Brazil, 14048-090.
R S OliveiraDivision of Pediatric Neurosurgery, Medical School of Ribeirão Preto, University of São Paulo, Ribeirão Preto, SP, Brazil.
M V SantosDivision of Pediatric Neurosurgery, Medical School of Ribeirão Preto, University of São Paulo, Ribeirão Preto, SP, Brazil.
A C Dos SantosDivision of Pediatric Neurosurgery, Medical School of Ribeirão Preto, University of São Paulo, Ribeirão Preto, SP, Brazil.
H R MachadoDivision of Diagnostic Neuroradiology, Medical School of Ribeirão Preto, University of São Paulo, Ribeirão Preto, SP, Brazil.
D G AbudDivision of Interventional Neuroradiology, Medical School of Ribeirão Preto, University of São Paulo, Avenida Bandeirantes, 3900, Monte Alegre, Ribeirão Preto, SP, Brazil, 14048-090. dgabud@fmrp.usp.br.
Universidade de São Paulo · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionIntracranial arteriovenous malformations (AVMs) are the most frequent cause of hemorrhagic strokes in the pediatric population. The study aim was to retrospectively assess the safety and efficacy of Onyx embolization with the intention to cure AVMs in a pediatric population.

methodsA retrospective analysis of all patients (<18 years) who underwent endovascular embolization using Onyx at our institution was conducted. The primary endpoint was the composite complete angiographic occlusion of AVM immediately after the last embolization session that had no procedure-related complication requiring emergency surgery. Secondary endpoints were angiographic occlusion rates, procedure-related complications, and clinical outcomes after treatment and at the 6-month follow-up

resultsTwenty-three patients (mean age, 11.7 years) underwent a total of 45 embolization sessions. The median Spetzler-Martin grade was 3 (range 1 to 4). The primary endpoint was achieved in 19 patients (82.6 %). Complete angiographic occlusion of the AVM was obtained in 21 patients (91.3 %) immediately after embolization and at the 6-month follow-up. Embolization-related complications were observed in three patients (13 %). None of the complications resulted in permanent functional disability or death. In two patients (8.7 %), the AVM could not be completely occluded by embolization alone and the patients were referred to radiosurgery and microsurgery, respectively.

conclusionOnyx embolization of AVM in pediatric patients with the intention to cure resulted in high occlusion rates without increasing neurological disability or death. The development of new embolization techniques and devices seems to improve the safety of Onyx embolization.

Indexed as

AdolescentCerebral AngiographyChildChild, PreschoolComputed Tomography AngiographyDimethyl SulfoxideEmbolization, TherapeuticFemaleHemostaticsHumansInfantIntracranial Arteriovenous MalformationsMalePolyvinylsRetrospective StudiesTreatment OutcomeDimethyl SulfoxideHemostaticsOnyx copolymerPolyvinylsBrain arteriovenous malformationsChildrenEndovascular embolizationIntracranial arteriovenous malformationsPediatric

Identifiers

PMID26909692
OpenAlexW2279461191

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.