Evidence map›Paper›PMID 26909566›Full record

ReviewEuropean journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP)2017

BART miRNAs: an unimaginable force in the development of nasopharyngeal carcinoma.

Youhong Wang, Zhen Guo, Yan Shu, Honghao Zhou, Hui Wang, Wei Zhang

Open access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed, 1 pooled it
1.9field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

34 citing papers in PubMed, 1 synthesis or guideline pooled it, 46 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 5 institutions in 2 countries.

Youhong WangaDepartment of Clinical Pharmacology, Xiangya Hospital, Central South University and Institute of Clinical Pharmacology, Central South University bDepartment of Radiation Oncology, Hunan Provincial Tumor Hospital & Affiliated Tumor Hospital of Xiangya Medical School, Central South University cHunan Key Laboratory of Pharmacogenetics dHunan Key Laboratory of Translational Radiation Oncology, ChangSha, People's Republic of China eDepartment of Pharmaceutical Sciences, School of Pharmacy, University of Maryland, Baltimore, Maryland, USA.
Zhen Guo
Yan Shu
Honghao Zhou
Hui Wang
Wei Zhang
Central South University · CNGTx (United States) · USPharmacoGenetics (China) · CNUniversity of Maryland, Baltimore · USXiangya Hospital Central South University · CN

Funding

Xenobiotic Transporter Regulation and IRIP FunctionR01GM099742 · NIGMS · UNIVERSITY OF MARYLAND BALTIMORE · PI SHU, YAN · 2012 to 2016
$1.6M
6 · The paper itself

Abstract

Nasopharyngeal carcinoma (NPC) is a head and neck cancer that represents a major health burden in Southern China and Southeast Asia. Although the close association of NPC with Epstein-Barr virus (EBV) infection has been demonstrated, its exact role in the pathogenesis of this malignancy is still unclear. The expression of EBV-encoded microRNAs, especially BART miRNAs, which are encoded from the BamHI-A region of the viral genome, is detected at a high level in NPC. miRNAs are small noncoding mRNAs that can positively regulate the virus to ensure accurate expression of viral genomes and to modify the gene expression of host cells by negative regulation. Accumulating evidence suggests that ebv-mir-BARTs play a critical role in host cell survival, immune escape, cell proliferation, cell apoptosis, and cancer metabolism, promoting the generation of NPC. This review will summarize our current understanding of the nature and function of ebv-mir-BARTs in NPC.

Indexed as

CarcinomaCarrier ProteinsHead and Neck NeoplasmsHumansMicroRNAsNasopharyngeal CarcinomaNasopharyngeal NeoplasmsTranscription FactorsARL2BP protein, humanCarrier ProteinsMicroRNAsTranscription Factors

Identifiers

PMID26909566
PMCPMC5321115
OpenAlexW2274565987

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.