ReviewAmerican journal of respiratory cell and molecular biology2016
Physiological Mechanisms of Airway Hyperresponsiveness in Obese Asthma.
Review in American journal of respiratory cell and molecular biology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
35 citing papers in PubMed, 1 synthesis or guideline pooled it, 53 citations in OpenAlex.
- Is Bariatric Surgery Better than Nonsurgical Weight Loss for Improving Asthma Control? A Systematic Review.Obesity surgery · 2021Pooled it
- A randomized trial of continuous positive airway pressure for the asthma of obesity.Respiratory research · 2025Trial
- Mechanistic study of inspiratory training in childhood Asthma: Rationale and methods of a pediatric clinical trial.Contemporary clinical trials communications · 2026Article
- Obesity and respiratory diseases: mechanisms, phenotypes, and clinical implications.Diabetology & metabolic syndrome · 2026Review
- Qufeng Jiejing formula ameliorated the injury of airway smooth muscle cells induced by platelet-derived growth factor-BB through the transforming growth factor-β1/Smads signaling pathway.Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan · 2025Article
- Relationship Between Plasma Leptin Levels and Airflow Limitation in the Small and Medium Airways in Young Adults.Journal of clinical medicine · 2025Article
- Serum inflammatory factors, vitamin D levels, and asthma severity in children with comorbid asthma and obesity/overweight: a comparative study.Frontiers in pediatrics · 2025Article
- Impact of smoking behaviors on asthma incidence and allcause mortality in middle-aged and older adults: A longitudinal study from China.Tobacco induced diseases · 2025Article
- A clinician's guide to effects of obesity on childhood asthma and into adulthood.Expert review of respiratory medicine · 2024Review
- Obesity-Associated Non-T2 Mechanisms in Obese Asthmatic Individuals.Biomedicines · 2023Review
- Metformin regulates the effects of IR and IGF-1R methylation on mast cell activation and airway reactivity in diabetic rats with asthma through miR-152-3p/DNMT1 axis.Cell biology and toxicology · 2023Article
- Trends of vitamin D in asthma in the pediatric population for two decades: a systematic review.Clinical and experimental pediatrics · 2023Article
- Chronic intermittent hypoxia increases airway hyperresponsiveness during house dust mites exposures in rats.Respiratory research · 2023Article
- Macrophages Orchestrate Airway Inflammation, Remodeling, and Resolution in Asthma.International journal of molecular sciences · 2023Review
- Mechanistic Links Between Obesity and Airway Pathobiology Inform Therapies for Obesity-Related Asthma.Paediatric drugs · 2023Review
- Role of small airway dysfunction in unexplained exertional dyspnoea.ERJ open research · 2023Article
- Pulmonary dysfunction in overweight and obese children with obstructive sleep apnoea.Endocrinology, diabetes & metabolism · 2023Article
- Respiratory complications of obesity: from early changes to respiratory failure.Breathe (Sheffield, England) · 2023Review
- Targeting of G-protein coupled receptor 40 alleviates airway hyperresponsiveness through RhoA/ROCK1 signaling pathway in obese asthmatic mice.Respiratory research · 2023Article
- Impact of Insulin Resistance on Asthma: Is There Truly No Role of "Obesity"?American journal of respiratory and critical care medicine · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
Obesity affects the incidence and severity of asthma in at least two major phenotypes: an early-onset allergic (EOA) form that is complicated by obesity and a late-onset nonallergic (LONA) form that occurs only in the setting of obesity. Both groups exhibit airway hyperresponsiveness to methacholine challenge but exhibit differential effects of weight loss. Measurements of lung function in patients with LONA obese asthma suggest that this group of individuals may simply be those unlucky enough to have airways that are more compliant than average, and that this leads to airway hyperresponsiveness at the reduced lung volumes caused by excess adipose tissue around the chest wall. In contrast, the frequent exacerbations in those with EOA obese asthma can potentially be explained by episodic inflammatory thickening of the airway wall synergizing with obesity-induced reductions in lung volume. These testable hypotheses are based on the strong likelihood that LONA and EOA obese asthma are distinct diseases. Both, however, may benefit from targeted therapeutics that impose elevations in lung volume.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.