ArticleNeuroImage. Clinical2016
Exploring the physiological correlates of chronic mild traumatic brain injury symptoms.
Article in NeuroImage. Clinical, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 3 of them syntheses that pooled it.
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Who cites it
16 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Functional Connectivity Changes on Resting-State fMRI after Mild Traumatic Brain Injury: A Systematic Review.AJNR. American journal of neuroradiology · 2024Pooled it
- Characterizing the Risk of Depression Following Mild Traumatic Brain Injury: A Meta-Analysis of the Literature Comparing Chronic mTBI to Non-mTBI Populations.Frontiers in neurology · 2020Pooled it
- The second decade of DTI in TBI part 1: a systematic review of mild TBI.Frontiers in neurologyPooled it
- A neuropsychological perspective on sensory hypersensitivity after acquired brain injury.Brain communications · 2026Review
- Temporal visual processing deficits in post concussion syndrome.Scientific reports · 2025Article
- Advancements in diagnosing Post-concussion Syndrome: insights into epidemiology, pathophysiology, neuropathology, neuroimaging, and salivary biomarkers.Acta neurologica Belgica · 2025Review
- Neurobiology of Chronic Pain, Posttraumatic Stress Disorder, and Mild Traumatic Brain Injury.Biology · 2025Review
- Assessment of Oculomotor Functions as a Biomarker in Mild Traumatic Brain Injury.Neurotrauma reports · 2024Article
- Review
- A review of brain regions and associated post-concussion symptoms.Frontiers in neurology · 2023Review
- Neurophysiological Biomarkers of Persistent Post-concussive Symptoms: A Scoping Review.Frontiers in neurology · 2021Article
- Structural neuroimaging in mild traumatic brain injury: A chronic effects of neurotrauma consortium study.International journal of methods in psychiatric research · 2019Observational
- Neuroradiological Changes Following Single or Repetitive Mild TBI.Frontiers in systems neuroscience · 2019Article
- The Dynamics of Concussion: Mapping Pathophysiology, Persistence, and Recovery With Causal-Loop Diagramming.Frontiers in neurology · 2018Article
- Differences in Brain Architecture in Remote Mild Traumatic Brain Injury.Journal of neurotrauma · 2017Article
- Mapping white-matter functional organization at rest and during naturalistic visual perception.NeuroImage · 2017Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
We report on the results of a multimodal imaging study involving behavioral assessments, evoked and resting-state BOLD fMRI, and DTI in chronic mTBI subjects. We found that larger task-evoked BOLD activity in the MT+/LO region in extra-striate visual cortex correlated with mTBI and PTSD symptoms, especially light sensitivity. Moreover, higher FA values near the left optic radiation (OR) were associated with both light sensitivity and higher BOLD activity in the MT+/LO region. The MT+/LO region was localized as a region of abnormal functional connectivity with central white matter regions previously found to have abnormal physiological signals during visual eye movement tracking (Astafiev et al., 2015). We conclude that mTBI symptoms and light sensitivity may be related to excessive responsiveness of visual cortex to sensory stimuli. This abnormal sensitivity may be related to chronic remodeling of white matter visual pathways acutely injured.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.