ArticleBiomicrofluidics2016
High-throughput and clogging-free microfluidic filtration platform for on-chip cell separation from undiluted whole blood.
Article in Biomicrofluidics, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
25 citing papers in PubMed, 70 citations in OpenAlex.
- From Clogging Mitigation to Clogging Acceleration: Particle Deposition Under Oscillatory Flow in Microfluidic Porous Media.Transport in porous media · 2026Article
- Isolation Techniques of Micro/Nano-Scaled Species for Biomedical Applications.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Review
- Robust and efficient separation of white blood cells from blood using a microfluidic chip with a pair of linearly tapered crossflow filter arrays.Mikrochimica acta · 2024Article
- NanoRidge filters: Fabrication strategies and performance optimization for nano-scale microfluidic particle filtration.Biomicrofluidics · 2024Article
- Recent advances in microfluidic cell separation to enable centrifugation-free, low extracorporeal volume leukapheresis in pediatric patients.Blood transfusion = Trasfusione del sangue · 2023Review
- Pneumatically Driven Microfluidic Platform and Fully Automated Particle Concentration System for the Capture and Enrichment of Pathogens.ACS omega · 2023Article
- Dynamics of flexible filaments in oscillatory shear flows.Journal of fluid mechanics · 2023Article
- Advances in Microfluidics for Single Red Blood Cell Analysis.Biosensors · 2023Review
- A high-throughput microfluidic device based on controlled incremental filtration to enable centrifugation-free, low extracorporeal volume leukapheresis.Scientific reports · 2022Article
- Inertia-Acoustophoresis Hybrid Microfluidic Device for Rapid and Efficient Cell Separation.Sensors (Basel, Switzerland) · 2022Article
- Single Red Blood Cell Hydrodynamic Traps via the Generative Design.Micromachines · 2022Article
- Progress of Microfluidic Continuous Separation Techniques for Micro-/Nanoscale Bioparticles.Biosensors · 2021Review
- A review of peristaltic micropumps.Sensors and actuators. A, Physical · 2021Article
- Nanotechnology-Assisted Isolation and Analysis of Circulating Tumor Cells on Microfluidic Devices.Micromachines · 2020Review
- Flow induced particle separation and collection through linear array pillar microfluidics device.Biomicrofluidics · 2020Article
- Label-free microfluidic sorting of microparticles.APL bioengineering · 2019Review
- On-chip immuno-agglutination assay based on a dynamic magnetic bead clump and a sheath-less flow cytometry.Biomicrofluidics · 2019Article
- Fabrication of polydimethylsiloxane nanofluidic chips under AFM tip-based nanomilling process.Nanoscale research letters · 2019Article
- An anti-clogging method for improving the performance and lifespan of blood plasma separation devices in real-time and continuous microfluidic systems.Scientific reports · 2018Article
- Isolation of cells from whole blood using shear-induced diffusion.Scientific reports · 2018Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Rapid separation of white blood cells from whole blood sample is often required for their subsequent analyses of functions and phenotypes, and many advances have been made in this field. However, most current microfiltration-based cell separation microfluidic chips still suffer from low-throughput and membrane clogging. This paper reports on a high-throughput and clogging-free microfluidic filtration platform, which features with an integrated bidirectional micropump and commercially available polycarbonate microporous membranes. The integrated bidirectional micropump enables the fluid to flush micropores back and forth, effectively avoiding membrane clogging. The microporous membrane allows red blood cells passing through high-density pores in a cross-flow mixed with dead-end filtration mode. All the separation processes, including blood and buffer loading, separation, and sample collection, are automatically controlled for easy operation and high throughput. Both microbead mixture and undiluted whole blood sample are separated by the platform effectively. In particular, for white blood cell separation, the chip recovered 72.1% white blood cells with an over 232-fold enrichment ratio at a throughput as high as 37.5 μl/min. This high-throughput, clogging-free, and highly integrated platform holds great promise for point-of-care blood pretreatment, analysis, and diagnosis applications.
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.