Evidence map›Paper›PMID 26909106›Full record

ArticleTheranostics2016

Quantitative Magnetic Particle Imaging Monitors the Transplantation, Biodistribution, and Clearance of Stem Cells In Vivo.

Bo Zheng, Marc P von See, Elaine Yu, Beliz Gunel, Kuan Lu, Tandis Vazin, David V Schaffer, Patrick W Goodwill, Steven M Conolly

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Theranostics, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 146 papers.

0numbers the graph read from it
0cells of the map it votes in
146citing papers in PubMed
14.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

146 citing papers in PubMed, 313 citations in OpenAlex.

  1. Feasibility of thermal dose painting during magnetic nanoparticle thermal therapy: a computational analysis.International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group · 2026
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  7. Multifunctional Magnetic Resonance Imaging Probes.Recent results in cancer research. Fortschritte der Krebsforschung. Progres dans les recherches sur le cancer · 2026
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86 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 2 countries.

Bo Zheng1. Department of Bioengineering, University of California at Berkeley, Berkeley, CA 94720, USA.
Marc P von See2. Institute of Medical Technology, Hamburg University of Technology, Hamburg, Germany.
Elaine Yu1. Department of Bioengineering, University of California at Berkeley, Berkeley, CA 94720, USA.
Beliz Gunel1. Department of Bioengineering, University of California at Berkeley, Berkeley, CA 94720, USA.
Kuan Lu1. Department of Bioengineering, University of California at Berkeley, Berkeley, CA 94720, USA.
Tandis Vazin3. Department of Chemical and Biomolecular Engineering, University of California at Berkeley, Berkeley, CA 94720, USA; 4. Department of Molecular and Cell Biology, University of California at Berkeley, Berkeley, CA 94720, USA.
David V Schaffer1. Department of Bioengineering, University of California at Berkeley, Berkeley, CA 94720, USA; 3. Department of Chemical and Biomolecular Engineering, University of California at Berkeley, Berkeley, CA 94720, USA; 4. Department of Molecular and Cell Biology, University of California at Berkeley, Berkeley, CA 94720, USA.
Patrick W Goodwill1. Department of Bioengineering, University of California at Berkeley, Berkeley, CA 94720, USA; 5. Magnetic Insight, Inc., Newark, CA 94560, USA.
Steven M Conolly1. Department of Bioengineering, University of California at Berkeley, Berkeley, CA 94720, USA; 6. Department of Electrical Engineering and Computer Science, University of California at Berkeley, Berkeley, CA 94720, USA.
University of California, Berkeley · USHamburg University of Technology · DE

Funding

Pre-clinical quantitation of ovarian cancer tumor burden using Magnetic Particle Imaging and non-dilutive cell labelingR01EB019458 · NIBIB · UNIVERSITY OF CALIFORNIA BERKELEY · PI BELL, CALEB B., CONOLLY, STEVEN M · 2015 to 2018
$1.9M
Magnetic Particle Imaging Angiography for Chronic Kidney Disease PatientsR01EB013689 · NIBIB · UNIVERSITY OF CALIFORNIA BERKELEY · PI CONOLLY, STEVEN M · 2011 to 2014
$1.6M
Magnetic Particle Imaging (MPI) for Functional Brain Imaging in HumansR24MH106053 · NIMH · MASSACHUSETTS GENERAL HOSPITAL · PI CONOLLY, STEVEN M, GRISWOLD, MARK · 2014 to 2016
$1.5M
NIBIB NIH HHS 1R01 EB019458NIBIB NIH HHS R01 EB013689NIBIB NIH HHS R01 EB019458NIMH NIH HHS 1R24MH106053NIMH NIH HHS R24 MH106053
6 · The paper itself

Abstract

Stem cell therapies have enormous potential for treating many debilitating diseases, including heart failure, stroke and traumatic brain injury. For maximal efficacy, these therapies require targeted cell delivery to specific tissues followed by successful cell engraftment. However, targeted delivery remains an open challenge. As one example, it is common for intravenous deliveries of mesenchymal stem cells (MSCs) to become entrapped in lung microvasculature instead of the target tissue. Hence, a robust, quantitative imaging method would be essential for developing efficacious cell therapies. Here we show that Magnetic Particle Imaging (MPI), a novel technique that directly images iron-oxide nanoparticle-tagged cells, can longitudinally monitor and quantify MSC administration in vivo. MPI offers near-ideal image contrast, depth penetration, and robustness; these properties make MPI both ultra-sensitive and linearly quantitative. Here, we imaged, for the first time, the dynamic trafficking of intravenous MSC administrations using MPI. Our results indicate that labeled MSC injections are immediately entrapped in lung tissue and then clear to the liver within one day, whereas standard iron oxide particle (Resovist) injections are immediately taken up by liver and spleen. Longitudinal MPI-CT imaging also indicated a clearance half-life of MSC iron oxide labels in the liver at 4.6 days. Finally, our ex vivo MPI biodistribution measurements of iron in liver, spleen, heart, and lungs after injection showed excellent agreement (R(2) = 0.943) with measurements from induction coupled plasma spectrometry. These results demonstrate that MPI offers strong utility for noninvasively imaging and quantifying the systemic distribution of cell therapies and other therapeutic agents.

Indexed as

MagneticsMesenchymal Stem Cell TransplantationAdministration, IntravenousAnimalsDiagnostic ImagingFemaleFerric CompoundsHumansMiceNanoparticlesRats, Inbred F344Staining and LabelingTissue DistributionFerric Compoundsferric oxidecell therapy trackingMagnetic particle imagingmesenchymal stem cellsquantitative imaging

Identifiers

PMID26909106
PMCPMC4737718
OpenAlexW2275153700

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.