ArticleFrontiers in microbiology2016
The S-layer Protein DR_2577 Binds Deinoxanthin and under Desiccation Conditions Protects against UV-Radiation in Deinococcus radiodurans.
Article in Frontiers in microbiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed.
- Airborne Bacterial Communities: Diversity, Survival Strategies and Functional Roles in the Atmosphere.Environmental microbiology reports · 2026Review
- Life resists chemistry not conditions.FEMS microbes · 2026Article
- Radiation-Resistant Bacteria Deinococcus radiodurans-Derived Extracellular Vesicles as Potential Radioprotectors.Advanced healthcare materials · 2025Article
- A new age in structural S-layer biology: Experimental and in silico milestones.The Journal of biological chemistry · 2025Review
- Microbiome dynamics in tank- and pond-reared Genetically Improved Farmed Tilapia (GIFT).Frontiers in microbiomes · 2025Article
- Advances in stress-tolerance elements for microbial cell factories.Synthetic and systems biotechnology · 2024Review
- Structural characterization and functional insights into the type II secretion system of the poly-extremophile Deinococcus radiodurans.The Journal of biological chemistry · 2024Article
- A novel UV-resistant bacterium Sphingomonas endolithica sp. nov., and genomic analysis, isolated from the north slope of Mount Everest.Antonie van Leeuwenhoek · 2023Article
- Extremophilic Solutions: The Role of Deinoxanthin in Counteracting UV-Induced Skin Harm.Current issues in molecular biology · 2023Article
- Deinococcus radiodurans-derived membrane vesicles protect HaCaT cells against HBiological procedures online · 2023Article
- Highly Water-Dispersed and Stable Deinoxanthin Nanocapsule for Effective Antioxidant and Anti-Inflammatory Activity.International journal of nanomedicine · 2023Article
- S-layer proteins as immune players: Tales from pathogenic and non-pathogenic bacteria.Current research in microbial sciences · 2023Review
- Isolation and characterization of a main porin from the outer membrane of Salinibacter ruber.Journal of bioenergetics and biomembranes · 2022Article
- The structured organization ofProceedings of the National Academy of Sciences of the United States of America · 2022Article
- Characterization of a robot-assisted UV-C disinfection for the inactivation of surface-associated microorganisms and viruses.Journal of photochemistry and photobiology · 2022Article
- A multidomain connector links the outer membrane and cell wall in phylogenetically deep-branching bacteria.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- The cryo-EM structure of the S-layer deinoxanthin-binding complex of Deinococcus radiodurans informs properties of its environmental interactions.The Journal of biological chemistry · 2022Article
- High Proportions of Radiation-Resistant Strains in Culturable Bacteria from the Taklimakan Desert.Biology · 2022Article
- Super-resolution confocal cryo-CLEM with cryo-FIB milling forCurrent research in structural biology · 2022Article
- Proteomic Response ofLife (Basel, Switzerland) · 2021Article
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4 authors.
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Abstract
Deinococcus radiodurans has the puzzling ability to withstand over a broad range of extreme conditions including high doses of ultraviolet radiation and deep desiccation. This bacterium is surrounded by a surface layer (S-layer) built of a regular repetition of several proteins, assembled to form a paracrystalline structure. Here we report that the deletion of a main constituent of this S-layer, the gene DR_2577, causes a decrease in the UVC resistance, especially in desiccated cells. Moreover, we show that the DR_2577 protein binds the carotenoid deinoxanthin, a strong protective antioxidant specific of this bacterium. A further spectroscopical characterization of the deinoxanthin-DR_2577 complex revealed features which could suggest a protective role of DR_2577. We propose that, especially under desiccation, the S-layer shields the bacterium from incident ultraviolet light and could behave as a first lane of defense against UV radiation.
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