Evidence map›Paper›PMID 26908866›Full record

ArticleCirculation. Cardiovascular quality and outcomes2016

Sex Differences in the Incidence of Peripheral Artery Disease in the Chronic Renal Insufficiency Cohort.

Grace J Wang, Pamela A Shaw, Raymond R Townsend, Amanda H Anderson, Dawei Xie, Xue Wang, Lisa C Nessel, Emile R Mohler, Stephen M Sozio, Bernard G Jaar and 10 more

Abstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Circulation. Cardiovascular quality and outcomes, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
3.1field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 40 citations in OpenAlex.

  1. Diabetes Genetic Clusters and Clinical Outcomes in the Chronic Renal Insufficiency Cohort.Clinical journal of the American Society of Nephrology : CJASN · 2026
    Article
  2. Implications of inflammation and sex in lower extremity arterial disease.European journal of clinical investigation · 2026
    Review
  3. Article
  4. Article
  5. Review
  6. Article
  7. Article
  8. Review
  9. Sex and Racial Disparities in Peripheral Artery Disease.Arteriosclerosis, thrombosis, and vascular biology · 2023
    Review
  10. Article
  11. Article
  12. Article
  13. Article
  14. Review
  15. Article
  16. Review
  17. Sex Differences in Cardiovascular Outcomes in CKD: Findings From the CRIC Study.American journal of kidney diseases : the official journal of the National Kidney Foundation · 2021
    Article
  18. Article
  19. Article
  20. Central Blood Pressure and Cardiovascular Outcomes in Chronic Kidney Disease.Clinical journal of the American Society of Nephrology : CJASN · 2018
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

20 authors at 8 institutions in 1 country.

Grace J WangFrom the Departments of Surgery (G.J.W., R.M.F.), Biostatistics and Epidemiology (P.A.S., A.H.A., D.X., X.W., L.C.N., H.I.F.), and Medicine (R.R.T., E.R.M., B.K.), University of Pennsylvania Perelman School of Medicine, Philadelphia; Department of Medicine, Johns Hopkins Medicine, Baltimore, MD (S.M.S., B.G.J.); Department of Medicine, Tulane University School of Medicine, New Orleans, LA (J.C.); Department of Medicine, Case Western Reserve University, Cleveland, OH (J.W.); Department of Nephrology and Hypertension, Cleveland Clinic, OH (J.J.T.); Department of Medicine, University of Michigan School of Medicine, Ann Arbor (A.O.); Department of Medicine, University of Illinois College of Medicine, Chicago (A.C.R.); and Tulane Office of Health Research, Tulane University Health Science Center, New Orleans, LA (E.L.). Grace.Wang@uphs.upenn.edu.
Pamela A ShawFrom the Departments of Surgery (G.J.W., R.M.F.), Biostatistics and Epidemiology (P.A.S., A.H.A., D.X., X.W., L.C.N., H.I.F.), and Medicine (R.R.T., E.R.M., B.K.), University of Pennsylvania Perelman School of Medicine, Philadelphia; Department of Medicine, Johns Hopkins Medicine, Baltimore, MD (S.M.S., B.G.J.); Department of Medicine, Tulane University School of Medicine, New Orleans, LA (J.C.); Department of Medicine, Case Western Reserve University, Cleveland, OH (J.W.); Department of Nephrology and Hypertension, Cleveland Clinic, OH (J.J.T.); Department of Medicine, University of Michigan School of Medicine, Ann Arbor (A.O.); Department of Medicine, University of Illinois College of Medicine, Chicago (A.C.R.); and Tulane Office of Health Research, Tulane University Health Science Center, New Orleans, LA (E.L.).
Raymond R TownsendFrom the Departments of Surgery (G.J.W., R.M.F.), Biostatistics and Epidemiology (P.A.S., A.H.A., D.X., X.W., L.C.N., H.I.F.), and Medicine (R.R.T., E.R.M., B.K.), University of Pennsylvania Perelman School of Medicine, Philadelphia; Department of Medicine, Johns Hopkins Medicine, Baltimore, MD (S.M.S., B.G.J.); Department of Medicine, Tulane University School of Medicine, New Orleans, LA (J.C.); Department of Medicine, Case Western Reserve University, Cleveland, OH (J.W.); Department of Nephrology and Hypertension, Cleveland Clinic, OH (J.J.T.); Department of Medicine, University of Michigan School of Medicine, Ann Arbor (A.O.); Department of Medicine, University of Illinois College of Medicine, Chicago (A.C.R.); and Tulane Office of Health Research, Tulane University Health Science Center, New Orleans, LA (E.L.).
Amanda H AndersonFrom the Departments of Surgery (G.J.W., R.M.F.), Biostatistics and Epidemiology (P.A.S., A.H.A., D.X., X.W., L.C.N., H.I.F.), and Medicine (R.R.T., E.R.M., B.K.), University of Pennsylvania Perelman School of Medicine, Philadelphia; Department of Medicine, Johns Hopkins Medicine, Baltimore, MD (S.M.S., B.G.J.); Department of Medicine, Tulane University School of Medicine, New Orleans, LA (J.C.); Department of Medicine, Case Western Reserve University, Cleveland, OH (J.W.); Department of Nephrology and Hypertension, Cleveland Clinic, OH (J.J.T.); Department of Medicine, University of Michigan School of Medicine, Ann Arbor (A.O.); Department of Medicine, University of Illinois College of Medicine, Chicago (A.C.R.); and Tulane Office of Health Research, Tulane University Health Science Center, New Orleans, LA (E.L.).
Dawei XieFrom the Departments of Surgery (G.J.W., R.M.F.), Biostatistics and Epidemiology (P.A.S., A.H.A., D.X., X.W., L.C.N., H.I.F.), and Medicine (R.R.T., E.R.M., B.K.), University of Pennsylvania Perelman School of Medicine, Philadelphia; Department of Medicine, Johns Hopkins Medicine, Baltimore, MD (S.M.S., B.G.J.); Department of Medicine, Tulane University School of Medicine, New Orleans, LA (J.C.); Department of Medicine, Case Western Reserve University, Cleveland, OH (J.W.); Department of Nephrology and Hypertension, Cleveland Clinic, OH (J.J.T.); Department of Medicine, University of Michigan School of Medicine, Ann Arbor (A.O.); Department of Medicine, University of Illinois College of Medicine, Chicago (A.C.R.); and Tulane Office of Health Research, Tulane University Health Science Center, New Orleans, LA (E.L.).
Xue WangFrom the Departments of Surgery (G.J.W., R.M.F.), Biostatistics and Epidemiology (P.A.S., A.H.A., D.X., X.W., L.C.N., H.I.F.), and Medicine (R.R.T., E.R.M., B.K.), University of Pennsylvania Perelman School of Medicine, Philadelphia; Department of Medicine, Johns Hopkins Medicine, Baltimore, MD (S.M.S., B.G.J.); Department of Medicine, Tulane University School of Medicine, New Orleans, LA (J.C.); Department of Medicine, Case Western Reserve University, Cleveland, OH (J.W.); Department of Nephrology and Hypertension, Cleveland Clinic, OH (J.J.T.); Department of Medicine, University of Michigan School of Medicine, Ann Arbor (A.O.); Department of Medicine, University of Illinois College of Medicine, Chicago (A.C.R.); and Tulane Office of Health Research, Tulane University Health Science Center, New Orleans, LA (E.L.).
Lisa C NesselFrom the Departments of Surgery (G.J.W., R.M.F.), Biostatistics and Epidemiology (P.A.S., A.H.A., D.X., X.W., L.C.N., H.I.F.), and Medicine (R.R.T., E.R.M., B.K.), University of Pennsylvania Perelman School of Medicine, Philadelphia; Department of Medicine, Johns Hopkins Medicine, Baltimore, MD (S.M.S., B.G.J.); Department of Medicine, Tulane University School of Medicine, New Orleans, LA (J.C.); Department of Medicine, Case Western Reserve University, Cleveland, OH (J.W.); Department of Nephrology and Hypertension, Cleveland Clinic, OH (J.J.T.); Department of Medicine, University of Michigan School of Medicine, Ann Arbor (A.O.); Department of Medicine, University of Illinois College of Medicine, Chicago (A.C.R.); and Tulane Office of Health Research, Tulane University Health Science Center, New Orleans, LA (E.L.).
Emile R MohlerFrom the Departments of Surgery (G.J.W., R.M.F.), Biostatistics and Epidemiology (P.A.S., A.H.A., D.X., X.W., L.C.N., H.I.F.), and Medicine (R.R.T., E.R.M., B.K.), University of Pennsylvania Perelman School of Medicine, Philadelphia; Department of Medicine, Johns Hopkins Medicine, Baltimore, MD (S.M.S., B.G.J.); Department of Medicine, Tulane University School of Medicine, New Orleans, LA (J.C.); Department of Medicine, Case Western Reserve University, Cleveland, OH (J.W.); Department of Nephrology and Hypertension, Cleveland Clinic, OH (J.J.T.); Department of Medicine, University of Michigan School of Medicine, Ann Arbor (A.O.); Department of Medicine, University of Illinois College of Medicine, Chicago (A.C.R.); and Tulane Office of Health Research, Tulane University Health Science Center, New Orleans, LA (E.L.).
Stephen M SozioFrom the Departments of Surgery (G.J.W., R.M.F.), Biostatistics and Epidemiology (P.A.S., A.H.A., D.X., X.W., L.C.N., H.I.F.), and Medicine (R.R.T., E.R.M., B.K.), University of Pennsylvania Perelman School of Medicine, Philadelphia; Department of Medicine, Johns Hopkins Medicine, Baltimore, MD (S.M.S., B.G.J.); Department of Medicine, Tulane University School of Medicine, New Orleans, LA (J.C.); Department of Medicine, Case Western Reserve University, Cleveland, OH (J.W.); Department of Nephrology and Hypertension, Cleveland Clinic, OH (J.J.T.); Department of Medicine, University of Michigan School of Medicine, Ann Arbor (A.O.); Department of Medicine, University of Illinois College of Medicine, Chicago (A.C.R.); and Tulane Office of Health Research, Tulane University Health Science Center, New Orleans, LA (E.L.).
Bernard G JaarFrom the Departments of Surgery (G.J.W., R.M.F.), Biostatistics and Epidemiology (P.A.S., A.H.A., D.X., X.W., L.C.N., H.I.F.), and Medicine (R.R.T., E.R.M., B.K.), University of Pennsylvania Perelman School of Medicine, Philadelphia; Department of Medicine, Johns Hopkins Medicine, Baltimore, MD (S.M.S., B.G.J.); Department of Medicine, Tulane University School of Medicine, New Orleans, LA (J.C.); Department of Medicine, Case Western Reserve University, Cleveland, OH (J.W.); Department of Nephrology and Hypertension, Cleveland Clinic, OH (J.J.T.); Department of Medicine, University of Michigan School of Medicine, Ann Arbor (A.O.); Department of Medicine, University of Illinois College of Medicine, Chicago (A.C.R.); and Tulane Office of Health Research, Tulane University Health Science Center, New Orleans, LA (E.L.).
Jing ChenFrom the Departments of Surgery (G.J.W., R.M.F.), Biostatistics and Epidemiology (P.A.S., A.H.A., D.X., X.W., L.C.N., H.I.F.), and Medicine (R.R.T., E.R.M., B.K.), University of Pennsylvania Perelman School of Medicine, Philadelphia; Department of Medicine, Johns Hopkins Medicine, Baltimore, MD (S.M.S., B.G.J.); Department of Medicine, Tulane University School of Medicine, New Orleans, LA (J.C.); Department of Medicine, Case Western Reserve University, Cleveland, OH (J.W.); Department of Nephrology and Hypertension, Cleveland Clinic, OH (J.J.T.); Department of Medicine, University of Michigan School of Medicine, Ann Arbor (A.O.); Department of Medicine, University of Illinois College of Medicine, Chicago (A.C.R.); and Tulane Office of Health Research, Tulane University Health Science Center, New Orleans, LA (E.L.).
Jackson WrightFrom the Departments of Surgery (G.J.W., R.M.F.), Biostatistics and Epidemiology (P.A.S., A.H.A., D.X., X.W., L.C.N., H.I.F.), and Medicine (R.R.T., E.R.M., B.K.), University of Pennsylvania Perelman School of Medicine, Philadelphia; Department of Medicine, Johns Hopkins Medicine, Baltimore, MD (S.M.S., B.G.J.); Department of Medicine, Tulane University School of Medicine, New Orleans, LA (J.C.); Department of Medicine, Case Western Reserve University, Cleveland, OH (J.W.); Department of Nephrology and Hypertension, Cleveland Clinic, OH (J.J.T.); Department of Medicine, University of Michigan School of Medicine, Ann Arbor (A.O.); Department of Medicine, University of Illinois College of Medicine, Chicago (A.C.R.); and Tulane Office of Health Research, Tulane University Health Science Center, New Orleans, LA (E.L.).
Jonathan J TaliercioFrom the Departments of Surgery (G.J.W., R.M.F.), Biostatistics and Epidemiology (P.A.S., A.H.A., D.X., X.W., L.C.N., H.I.F.), and Medicine (R.R.T., E.R.M., B.K.), University of Pennsylvania Perelman School of Medicine, Philadelphia; Department of Medicine, Johns Hopkins Medicine, Baltimore, MD (S.M.S., B.G.J.); Department of Medicine, Tulane University School of Medicine, New Orleans, LA (J.C.); Department of Medicine, Case Western Reserve University, Cleveland, OH (J.W.); Department of Nephrology and Hypertension, Cleveland Clinic, OH (J.J.T.); Department of Medicine, University of Michigan School of Medicine, Ann Arbor (A.O.); Department of Medicine, University of Illinois College of Medicine, Chicago (A.C.R.); and Tulane Office of Health Research, Tulane University Health Science Center, New Orleans, LA (E.L.).
Akinlolu OjoFrom the Departments of Surgery (G.J.W., R.M.F.), Biostatistics and Epidemiology (P.A.S., A.H.A., D.X., X.W., L.C.N., H.I.F.), and Medicine (R.R.T., E.R.M., B.K.), University of Pennsylvania Perelman School of Medicine, Philadelphia; Department of Medicine, Johns Hopkins Medicine, Baltimore, MD (S.M.S., B.G.J.); Department of Medicine, Tulane University School of Medicine, New Orleans, LA (J.C.); Department of Medicine, Case Western Reserve University, Cleveland, OH (J.W.); Department of Nephrology and Hypertension, Cleveland Clinic, OH (J.J.T.); Department of Medicine, University of Michigan School of Medicine, Ann Arbor (A.O.); Department of Medicine, University of Illinois College of Medicine, Chicago (A.C.R.); and Tulane Office of Health Research, Tulane University Health Science Center, New Orleans, LA (E.L.).
Ana C RicardoFrom the Departments of Surgery (G.J.W., R.M.F.), Biostatistics and Epidemiology (P.A.S., A.H.A., D.X., X.W., L.C.N., H.I.F.), and Medicine (R.R.T., E.R.M., B.K.), University of Pennsylvania Perelman School of Medicine, Philadelphia; Department of Medicine, Johns Hopkins Medicine, Baltimore, MD (S.M.S., B.G.J.); Department of Medicine, Tulane University School of Medicine, New Orleans, LA (J.C.); Department of Medicine, Case Western Reserve University, Cleveland, OH (J.W.); Department of Nephrology and Hypertension, Cleveland Clinic, OH (J.J.T.); Department of Medicine, University of Michigan School of Medicine, Ann Arbor (A.O.); Department of Medicine, University of Illinois College of Medicine, Chicago (A.C.R.); and Tulane Office of Health Research, Tulane University Health Science Center, New Orleans, LA (E.L.).
Eva LustigovaFrom the Departments of Surgery (G.J.W., R.M.F.), Biostatistics and Epidemiology (P.A.S., A.H.A., D.X., X.W., L.C.N., H.I.F.), and Medicine (R.R.T., E.R.M., B.K.), University of Pennsylvania Perelman School of Medicine, Philadelphia; Department of Medicine, Johns Hopkins Medicine, Baltimore, MD (S.M.S., B.G.J.); Department of Medicine, Tulane University School of Medicine, New Orleans, LA (J.C.); Department of Medicine, Case Western Reserve University, Cleveland, OH (J.W.); Department of Nephrology and Hypertension, Cleveland Clinic, OH (J.J.T.); Department of Medicine, University of Michigan School of Medicine, Ann Arbor (A.O.); Department of Medicine, University of Illinois College of Medicine, Chicago (A.C.R.); and Tulane Office of Health Research, Tulane University Health Science Center, New Orleans, LA (E.L.).
Ronald M FairmanFrom the Departments of Surgery (G.J.W., R.M.F.), Biostatistics and Epidemiology (P.A.S., A.H.A., D.X., X.W., L.C.N., H.I.F.), and Medicine (R.R.T., E.R.M., B.K.), University of Pennsylvania Perelman School of Medicine, Philadelphia; Department of Medicine, Johns Hopkins Medicine, Baltimore, MD (S.M.S., B.G.J.); Department of Medicine, Tulane University School of Medicine, New Orleans, LA (J.C.); Department of Medicine, Case Western Reserve University, Cleveland, OH (J.W.); Department of Nephrology and Hypertension, Cleveland Clinic, OH (J.J.T.); Department of Medicine, University of Michigan School of Medicine, Ann Arbor (A.O.); Department of Medicine, University of Illinois College of Medicine, Chicago (A.C.R.); and Tulane Office of Health Research, Tulane University Health Science Center, New Orleans, LA (E.L.).
Harold I FeldmanFrom the Departments of Surgery (G.J.W., R.M.F.), Biostatistics and Epidemiology (P.A.S., A.H.A., D.X., X.W., L.C.N., H.I.F.), and Medicine (R.R.T., E.R.M., B.K.), University of Pennsylvania Perelman School of Medicine, Philadelphia; Department of Medicine, Johns Hopkins Medicine, Baltimore, MD (S.M.S., B.G.J.); Department of Medicine, Tulane University School of Medicine, New Orleans, LA (J.C.); Department of Medicine, Case Western Reserve University, Cleveland, OH (J.W.); Department of Nephrology and Hypertension, Cleveland Clinic, OH (J.J.T.); Department of Medicine, University of Michigan School of Medicine, Ann Arbor (A.O.); Department of Medicine, University of Illinois College of Medicine, Chicago (A.C.R.); and Tulane Office of Health Research, Tulane University Health Science Center, New Orleans, LA (E.L.).
Bonnie KyFrom the Departments of Surgery (G.J.W., R.M.F.), Biostatistics and Epidemiology (P.A.S., A.H.A., D.X., X.W., L.C.N., H.I.F.), and Medicine (R.R.T., E.R.M., B.K.), University of Pennsylvania Perelman School of Medicine, Philadelphia; Department of Medicine, Johns Hopkins Medicine, Baltimore, MD (S.M.S., B.G.J.); Department of Medicine, Tulane University School of Medicine, New Orleans, LA (J.C.); Department of Medicine, Case Western Reserve University, Cleveland, OH (J.W.); Department of Nephrology and Hypertension, Cleveland Clinic, OH (J.J.T.); Department of Medicine, University of Michigan School of Medicine, Ann Arbor (A.O.); Department of Medicine, University of Illinois College of Medicine, Chicago (A.C.R.); and Tulane Office of Health Research, Tulane University Health Science Center, New Orleans, LA (E.L.).
CRIC Study Investigators
Case Western Reserve University · USCleveland Clinic · USJohns Hopkins Medicine · USJohns Hopkins University · USUniversity of Michigan–Ann Arbor · USTulane University · USIllinois College · USUniversity of Illinois Chicago · US

Funding

UCSF CLINICAL AND TRANSLATIONAL SCIENCE INSTITUTEUL1RR024131 · NCRR · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI JOHNSTON, S. CLAIBORNE · 2006 to 2011
$111.2M
Scientific and Data Coordinating Center(SDCC) for the P*U01DK060990 · NIDDK · UNIVERSITY OF PENNSYLVANIA · PI FELDMAN, HAROLD I · 2001 to 2017
$50.1M
Clinical and Translational Science Collaborative of ClevelandUL1TR000439 · NCATS · CASE WESTERN RESERVE UNIVERSITY · PI KONSTAN, MICHAEL W. · 2012 to 2016
$50.0M
Michigan Institute for Clinical and Health Research (MCHR)UL1TR000433 · NCATS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI MASHOUR, GEORGE ALEXANDER · 2012 to 2016
$49.9M
Institutional Clinical and Translational Science AwardUL1TR000003 · NCATS · UNIVERSITY OF PENNSYLVANIA · PI FITZGERALD, GARRET A · 2012 to 2015
$38.9M
Zonulin Antibodies in Intestinal Permeabilitiy in IDDMM01RR016500 · NCRR · UNIVERSITY OF MARYLAND BALTIMORE · PI ONUKWUGHA, EBERECHUKWU · 2002 to 2009
$20.2M
Study of the Care and Outcomes of REnal InsufficiencyU01DK060902 · NIDDK · KAISER FOUNDATION RESEARCH INSTITUTE · PI GO, ALAN S · 2001 to 2025
$19.5M
Limited Competition for the Continuation of the Chronic Renal Insufficiency CohorU01DK061021 · NIDDK · CASE WESTERN RESERVE UNIVERSITY · PI RAHMAN, MAHBOOB · 2001 to 2025
$17.3M
Prospective Renal Insufficiency Cohort Evaluation:PRICEU01DK060984 · NIDDK · UNIVERSITY OF PENNSYLVANIA · PI COHEN, DEBBIE L · 2001 to 2025
$17.0M
Prospective Cohort Study of Chronic Renal InsufficiencyU01DK061028 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI RAO, PANDURANGA S · 2001 to 2025
$16.9M
Limited Competition for the Continuation of the Chronic Renal Insufficiency Cohort (CRIC) Hopkins Clinical CenterU01DK061022 · NIDDK · JOHNS HOPKINS UNIVERSITY · PI APPEL, LAWRENCE JOHN · 2001 to 2025
$15.7M
Proposal for a Chicago-CRIC Clinical CenterU01DK060980 · NIDDK · UNIVERSITY OF ILLINOIS AT CHICAGO · PI LASH, JAMES P. · 2001 to 2025
$15.4M
NCATS NIH HHS UL1 TR000003NCATS NIH HHS UL1TR000003NCATS NIH HHS UL1 TR-000424NCATS NIH HHS UL1 TR000424NCATS NIH HHS UL1 TR000433NCATS NIH HHS UL1TR000433NCATS NIH HHS UL1 TR000439NCATS NIH HHS UL1TR000439NCRR NIH HHS CTSA UL1RR029879NCRR NIH HHS GCRC M01 RR-16500NCRR NIH HHS M01 RR016500NCRR NIH HHS UL1 RR-024131NCRR NIH HHS UL1 RR024131NCRR NIH HHS UL1 RR029879NIDDK NIH HHS K01 DK092353NIDDK NIH HHS K01DK092353NIDDK NIH HHS K23 DK094829NIDDK NIH HHS R01 DK072231NIDDK NIH HHS R01 DK139225NIDDK NIH HHS U01 DK060902NIDDK NIH HHS U01DK060902NIDDK NIH HHS U01 DK060963NIDDK NIH HHS U01DK060963NIDDK NIH HHS U01 DK060980NIDDK NIH HHS U01DK060980NIDDK NIH HHS U01 DK060984NIDDK NIH HHS U01DK060984NIDDK NIH HHS U01 DK060990NIDDK NIH HHS U01DK060990NIDDK NIH HHS U01 DK061021NIDDK NIH HHS U01DK061021NIDDK NIH HHS U01 DK061022NIDDK NIH HHS U01DK061022NIDDK NIH HHS U01 DK061028NIDDK NIH HHS U01DK061028NIGMS NIH HHS P30 GM103337NIGMS NIH HHS P30GM103337
6 · The paper itself

Abstract

backgroundTo define how the incidence of peripheral artery disease (PAD) in chronic kidney disease differs according to sex and age. METHODS AND

resultsThe Chronic Renal Insufficiency Cohort (CRIC) is a multicenter, prospective cohort study of chronic kidney disease participants. Fine and Gray methods were used to determine the cumulative incidence of PAD, defined by an ankle brachial index <0.90 or a confirmed PAD event, with death as a competing event. Adjusted subdistribution hazard ratios from the Fine and Gray model determined the risk of PAD according to sex. A priori, we hypothesized that the relationship between sex and cumulative incidence of PAD differed according to age. The mean age of the 3174 participants in this study was 56.6 years and consisted of 55% males. During a median follow-up of 5.9 years, 17.8% developed PAD, 13.0% were lost to follow-up and 11.1% died. Females had a 1.53-fold greater adjusted PAD risk compared with males (95% confidence interval, 1.27-1.84; P<0.001). These sex-related differences in PAD risk also differed by age (P=0.013). Women, compared with men were at a markedly increased risk for PAD at younger ages; however, at ages >70 years, the risk was similar across both the sexes. Older men had a substantially greater PAD risk compared with younger men. In women, PAD risk did not vary with age.

conclusionsFemales with chronic kidney disease have a higher PAD risk compared with males at younger ages. There is an important need to improve our understanding of the biological and clinical basis for these differences.

Indexed as

AdultAgedCohort StudiesFemaleHumansIncidenceMaleMiddle AgedPeripheral Arterial DiseaseProspective StudiesRenal Insufficiency, ChronicRiskSex Characteristicsankle brachial indexepidemiologymortalityperipheral artery diseasesex

Identifiers

PMID26908866
PMCPMC4770580
OpenAlexW2301244336

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.