Evidence map›Paper›PMID 26908865›Full record

ReviewCirculation. Cardiovascular quality and outcomes2016

Field Synopsis of Sex in Clinical Prediction Models for Cardiovascular Disease.

Jessica K Paulus, Benjamin S Wessler, Christine Lundquist, Lana L Y Lai, Gowri Raman, Jennifer S Lutz, David M Kent

Open access · bronzeAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Circulation. Cardiovascular quality and outcomes, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 2 pooled it
1.8field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 2 syntheses or guidelines pooled it, 11 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Review
  4. Article
  5. Acetaminophen-induced Acute Liver Failure Is More Common and More Severe in Women.Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association · 2018
    Article
  6. Article
  7. Review
  8. Annual Women's Issue.Circulation. Cardiovascular quality and outcomes · 2016
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Jessica K PaulusPredictive Analytics and Comparative Effectiveness (PACE) Center (J.K.P., B.S.W., C.L., L.L.Y.L., J.S.L., D.M.K.), Institute for Clinical Research and Health Policy Studies (ICRHPS), Tufts Medical Center/Tufts University School of Medicine and Center for Clinical Evidence Synthesis (G.R.), Institute for Clinical Research and Health Policy Studies (ICRHPS), Tufts Medical Center/Tufts University School of Medicine, Boston, MA; and Division of Cardiology, Tufts Medical Center, Boston, MA (B.S.W.). jpaulus@tuftsmedicalcenter.org.
Benjamin S WesslerPredictive Analytics and Comparative Effectiveness (PACE) Center (J.K.P., B.S.W., C.L., L.L.Y.L., J.S.L., D.M.K.), Institute for Clinical Research and Health Policy Studies (ICRHPS), Tufts Medical Center/Tufts University School of Medicine and Center for Clinical Evidence Synthesis (G.R.), Institute for Clinical Research and Health Policy Studies (ICRHPS), Tufts Medical Center/Tufts University School of Medicine, Boston, MA; and Division of Cardiology, Tufts Medical Center, Boston, MA (B.S.W.).
Christine LundquistPredictive Analytics and Comparative Effectiveness (PACE) Center (J.K.P., B.S.W., C.L., L.L.Y.L., J.S.L., D.M.K.), Institute for Clinical Research and Health Policy Studies (ICRHPS), Tufts Medical Center/Tufts University School of Medicine and Center for Clinical Evidence Synthesis (G.R.), Institute for Clinical Research and Health Policy Studies (ICRHPS), Tufts Medical Center/Tufts University School of Medicine, Boston, MA; and Division of Cardiology, Tufts Medical Center, Boston, MA (B.S.W.).
Lana L Y LaiPredictive Analytics and Comparative Effectiveness (PACE) Center (J.K.P., B.S.W., C.L., L.L.Y.L., J.S.L., D.M.K.), Institute for Clinical Research and Health Policy Studies (ICRHPS), Tufts Medical Center/Tufts University School of Medicine and Center for Clinical Evidence Synthesis (G.R.), Institute for Clinical Research and Health Policy Studies (ICRHPS), Tufts Medical Center/Tufts University School of Medicine, Boston, MA; and Division of Cardiology, Tufts Medical Center, Boston, MA (B.S.W.).
Gowri RamanPredictive Analytics and Comparative Effectiveness (PACE) Center (J.K.P., B.S.W., C.L., L.L.Y.L., J.S.L., D.M.K.), Institute for Clinical Research and Health Policy Studies (ICRHPS), Tufts Medical Center/Tufts University School of Medicine and Center for Clinical Evidence Synthesis (G.R.), Institute for Clinical Research and Health Policy Studies (ICRHPS), Tufts Medical Center/Tufts University School of Medicine, Boston, MA; and Division of Cardiology, Tufts Medical Center, Boston, MA (B.S.W.).
Jennifer S LutzPredictive Analytics and Comparative Effectiveness (PACE) Center (J.K.P., B.S.W., C.L., L.L.Y.L., J.S.L., D.M.K.), Institute for Clinical Research and Health Policy Studies (ICRHPS), Tufts Medical Center/Tufts University School of Medicine and Center for Clinical Evidence Synthesis (G.R.), Institute for Clinical Research and Health Policy Studies (ICRHPS), Tufts Medical Center/Tufts University School of Medicine, Boston, MA; and Division of Cardiology, Tufts Medical Center, Boston, MA (B.S.W.).
David M KentPredictive Analytics and Comparative Effectiveness (PACE) Center (J.K.P., B.S.W., C.L., L.L.Y.L., J.S.L., D.M.K.), Institute for Clinical Research and Health Policy Studies (ICRHPS), Tufts Medical Center/Tufts University School of Medicine and Center for Clinical Evidence Synthesis (G.R.), Institute for Clinical Research and Health Policy Studies (ICRHPS), Tufts Medical Center/Tufts University School of Medicine, Boston, MA; and Division of Cardiology, Tufts Medical Center, Boston, MA (B.S.W.).
Tufts University · US

Funding

Value of Personalized Risk InformationU01NS086294 · NINDS · TUFTS MEDICAL CENTER · PI KENT, DAVID M, NEUMANN, PETER · 2013 to 2017
$2.6M
NINDS NIH HHS U01 NS086294NINDS NIH HHS U01NS086294
6 · The paper itself

Abstract

backgroundSeveral widely used risk scores for cardiovascular disease (CVD) incorporate sex effects, yet there has been no systematic summary of the role of sex in clinical prediction models (CPMs). To better understand the potential of these models to support sex-specific care, we conducted a field synopsis of sex effects in CPMs for CVD. METHODS AND

resultsWe identified CPMs in the Tufts Predictive Analytics and Comparative Effectiveness CPM Registry, a comprehensive database of CVD CPMs published from January 1990 to May 2012. We report the proportion of models including sex effects on CVD incidence or prognosis, summarize the directionality of the predictive effects of sex, and explore factors influencing the inclusion of sex. Of 592 CVD-related CPMs, 193 (33%) included sex as a predictor or presented sex-stratified models. Sex effects were included in 78% (53/68) of models predicting incidence of CVD in a general population, versus only 35% (59/171), 21% (12/58), and 17% (12/72) of models predicting outcomes in patients with coronary artery disease, stroke, and heart failure, respectively. Among sex-including CPMs, women with heart failure were at lower mortality risk in 8 of 8 models; women undergoing revascularization for coronary artery disease were at higher mortality risk in 10 of 12 models. Factors associated with the inclusion of sex effects included the number of outcome events and using cohorts at-risk for CVD (rather than with established CVD).

conclusionsAlthough CPMs hold promise for supporting sex-specific decision making in CVD clinical care, sex effects are included in only one third of published CPMs.

Indexed as

Cardiovascular DiseasesFemaleHumansIncidenceMaleModels, TheoreticalSex Characteristicscardiovascular diseasesprevention and controlprognosisrisk factorssexsex characteristicswomen

Identifiers

PMID26908865
PMCPMC5573163
OpenAlexW2332634504

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.