Evidence map›Paper›PMID 26908864›Full record

ArticleCirculation. Cardiovascular quality and outcomes2016

Association Between a Healthy Heart Score and the Development of Clinical Cardiovascular Risk Factors Among Women: Potential Role for Primordial Prevention.

Mercedes Sotos-Prieto, Josiemer Mattei, Frank B Hu, Andrea K Chomistek, Eric B Rimm, Walter C Willett, A Heather Eliassen, Stephanie E Chiuve

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Circulation. Cardiovascular quality and outcomes, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.6field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 23 citations in OpenAlex.

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  12. Annual Women's Issue.Circulation. Cardiovascular quality and outcomes · 2016
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Mercedes Sotos-PrietoFrom the Departments of Nutrition (M.S.-P., J.M., F.B.H., E.B.R., W.C.W., S.E.C.) and Epidemiology (F.B.H., E.B.R., W.C.W., A.H.E., S.E.C.), Harvard T.H. Chan School of Public Health, Boston, MA; Channing Division of Network Medicine (F.B.H., E.B.R., W.C.W., A.H.E.) and Division of Preventive Medicine, Department of Medicine (S.E.C.), Brigham and Women's Hospital and Harvard Medical School, Boston, MA; and Department of Epidemiology and Biostatistics, School of Public Health, Indiana University, Bloomington (A.K.C.). msotosp@hsph.harvard.edu.
Josiemer MatteiFrom the Departments of Nutrition (M.S.-P., J.M., F.B.H., E.B.R., W.C.W., S.E.C.) and Epidemiology (F.B.H., E.B.R., W.C.W., A.H.E., S.E.C.), Harvard T.H. Chan School of Public Health, Boston, MA; Channing Division of Network Medicine (F.B.H., E.B.R., W.C.W., A.H.E.) and Division of Preventive Medicine, Department of Medicine (S.E.C.), Brigham and Women's Hospital and Harvard Medical School, Boston, MA; and Department of Epidemiology and Biostatistics, School of Public Health, Indiana University, Bloomington (A.K.C.).
Frank B HuFrom the Departments of Nutrition (M.S.-P., J.M., F.B.H., E.B.R., W.C.W., S.E.C.) and Epidemiology (F.B.H., E.B.R., W.C.W., A.H.E., S.E.C.), Harvard T.H. Chan School of Public Health, Boston, MA; Channing Division of Network Medicine (F.B.H., E.B.R., W.C.W., A.H.E.) and Division of Preventive Medicine, Department of Medicine (S.E.C.), Brigham and Women's Hospital and Harvard Medical School, Boston, MA; and Department of Epidemiology and Biostatistics, School of Public Health, Indiana University, Bloomington (A.K.C.).
Andrea K ChomistekFrom the Departments of Nutrition (M.S.-P., J.M., F.B.H., E.B.R., W.C.W., S.E.C.) and Epidemiology (F.B.H., E.B.R., W.C.W., A.H.E., S.E.C.), Harvard T.H. Chan School of Public Health, Boston, MA; Channing Division of Network Medicine (F.B.H., E.B.R., W.C.W., A.H.E.) and Division of Preventive Medicine, Department of Medicine (S.E.C.), Brigham and Women's Hospital and Harvard Medical School, Boston, MA; and Department of Epidemiology and Biostatistics, School of Public Health, Indiana University, Bloomington (A.K.C.).
Eric B RimmFrom the Departments of Nutrition (M.S.-P., J.M., F.B.H., E.B.R., W.C.W., S.E.C.) and Epidemiology (F.B.H., E.B.R., W.C.W., A.H.E., S.E.C.), Harvard T.H. Chan School of Public Health, Boston, MA; Channing Division of Network Medicine (F.B.H., E.B.R., W.C.W., A.H.E.) and Division of Preventive Medicine, Department of Medicine (S.E.C.), Brigham and Women's Hospital and Harvard Medical School, Boston, MA; and Department of Epidemiology and Biostatistics, School of Public Health, Indiana University, Bloomington (A.K.C.).
Walter C WillettFrom the Departments of Nutrition (M.S.-P., J.M., F.B.H., E.B.R., W.C.W., S.E.C.) and Epidemiology (F.B.H., E.B.R., W.C.W., A.H.E., S.E.C.), Harvard T.H. Chan School of Public Health, Boston, MA; Channing Division of Network Medicine (F.B.H., E.B.R., W.C.W., A.H.E.) and Division of Preventive Medicine, Department of Medicine (S.E.C.), Brigham and Women's Hospital and Harvard Medical School, Boston, MA; and Department of Epidemiology and Biostatistics, School of Public Health, Indiana University, Bloomington (A.K.C.).
A Heather EliassenFrom the Departments of Nutrition (M.S.-P., J.M., F.B.H., E.B.R., W.C.W., S.E.C.) and Epidemiology (F.B.H., E.B.R., W.C.W., A.H.E., S.E.C.), Harvard T.H. Chan School of Public Health, Boston, MA; Channing Division of Network Medicine (F.B.H., E.B.R., W.C.W., A.H.E.) and Division of Preventive Medicine, Department of Medicine (S.E.C.), Brigham and Women's Hospital and Harvard Medical School, Boston, MA; and Department of Epidemiology and Biostatistics, School of Public Health, Indiana University, Bloomington (A.K.C.).
Stephanie E ChiuveFrom the Departments of Nutrition (M.S.-P., J.M., F.B.H., E.B.R., W.C.W., S.E.C.) and Epidemiology (F.B.H., E.B.R., W.C.W., A.H.E., S.E.C.), Harvard T.H. Chan School of Public Health, Boston, MA; Channing Division of Network Medicine (F.B.H., E.B.R., W.C.W., A.H.E.) and Division of Preventive Medicine, Department of Medicine (S.E.C.), Brigham and Women's Hospital and Harvard Medical School, Boston, MA; and Department of Epidemiology and Biostatistics, School of Public Health, Indiana University, Bloomington (A.K.C.).
Brigham and Women's Hospital · USHarvard University · US

Funding

Transgenic CoreP30DK046200 · NIDDK · TUFTS MEDICAL CENTER · PI LOWELL, BRADFORD B · 1992 to 2021
$25.0M
Indiana Clinical and Translational Sciences InstituteUL1TR001108 · NCATS · INDIANA UNIVERSITY INDIANAPOLIS · PI DENNE, SCOTT C., SHEKHAR, ANANTHA · 2013 to 2017
$23.3M
Life Course Cancer Epidemiology Cohort in WomenUM1CA176726 · NCI · HARVARD SCHOOL OF PUBLIC HEALTH · PI WILLETT, WALTER C. · 2013 to 2017
$15.7M
DIETARY PATTERNS AND RISK OF CARDIOVASCULAR DISEASER01HL060712 · NHLBI · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI HU, FRANK B, QI, QIBIN · 1998 to 2021
$8.0M
Role of fatty acid metabolism for the prevention of sudden cardiac deathR00HL097068 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI CHIUVE, STEPHANIE ELIZABETH · 2013 to 2015
$736k
Diet quality and cardiometabolic disparities among Latino ethnic subgroupsK01HL120951 · NHLBI · HARVARD SCHOOL OF PUBLIC HEALTH · PI MATTEI, JOSIEMER · 2014 to 2018
$689k
Role of fatty acid metabolism for the prevention of sudden cardiac deathK99HL097068 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI CHIUVE, STEPHANIE ELIZABETH · 2010 to 2011
$232k
NCATS NIH HHS UL1 TR001108NCI NIH HHS UM1 CA176726NHLBI NIH HHS HL097068NHLBI NIH HHS HL60712NHLBI NIH HHS K01 HL120951NHLBI NIH HHS K99 HL097068NHLBI NIH HHS L30 HL094250NHLBI NIH HHS R00 HL097068NHLBI NIH HHS R01 HL060712NIDDK NIH HHS P30 DK046200
6 · The paper itself

Abstract

backgroundThe prevailing efforts for cardiovascular disease (CVD) prevention focused on treatment of common CVD risk factors rather than primordial prevention of risk factors through health behaviors. The previously validated Healthy Heart Score effectively predicted the 20-year risk of CVD in midadulthood; however, it is unknown whether this risk score is associated with clinically relevant CVD risk factors. METHODS AND

resultsWe analyzed the association between the Healthy Heart Score and the incidence of clinical CVD risk factors, including diabetes mellitus, hypertension, and hypercholesterolemia among 69 505 US women in the Nurses' Health Study II (NHSII; 1991-2011). The Healthy Heart Score estimates the 20-year CVD risk based on 9 lifestyle factors; thus, a higher score reflected a higher predictive CVD risk. During 20 years, we documented 3275 incident cases of diabetes mellitus, 17 420 of hypertension, and 24 385 of hypercholesterolemia. Women with higher predicted CVD risk based on the Healthy Heart Score (highest quintile versus lowest quintile) had significantly greater risk of each clinical risk factor individually (hazard ratios: 18.1 [95% confidence interval, 14.4-22.7] for diabetes mellitus, 5.10 [4.66-5.57] for hypertension, and 2.57 [2.40-2.75] for hypercholesterolemia). The hazard ratio for developing the high-CVD profile was 52.5 (33.6-82.1). These associations were most pronounced among women who were younger, were nonsmokers, or had optimal weight.

conclusionsAn absolute 20-year risk of CVD, estimated by the Healthy Heart Score, was strongly associated with the development of CVD clinically relevant risk factors. This risk score may serve as the first step for CVD risk assessment in primordial prevention.

Indexed as

Primary PreventionAdultBody Mass IndexCardiovascular DiseasesCohort StudiesFemaleHumansLife StyleProspective StudiesRisk Factorscardiovascular diseasesepidemiologylifestyleprevention and controlwomen

Identifiers

PMID26908864
PMCPMC4772164
OpenAlexW2289767719

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.