SynthesisClinical infectious diseases : an official publication of the Infectious Diseases Society of America2016
Protective Effect of Contemporary Pertussis Vaccines: A Systematic Review and Meta-analysis.
Synthesis in Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
31 citing papers in PubMed, 3 syntheses or guidelines pooled it, 66 citations in OpenAlex.
- The association between vaccine hesitancy and pertussis: a systematic review and meta-analysis.Italian journal of pediatrics · 2023Pooled it
- The effectiveness and safety of pertussis booster vaccination for adolescents and adults: A systematic review and meta-analysis.Medicine · 2019Pooled it
- Acellular pertussis vaccines effectiveness over time: A systematic review, meta-analysis and modeling study.PloS one · 2018Pooled it
- Trial
- Risk-of-bias assessment of vaccine effectiveness studies: a scoping review of systematic reviews.Epidemiology and infection · 2026Article
- Mechanisms of natural and vaccine-induced immunity to Bordetella pertussis.PLoS pathogens · 2026Review
- Effectiveness and impact of the 2-component acellular pertussis vaccine as a preschool booster in Finland - A register-based study.PLOS global public health · 2026Article
- The cost of inaction to strengthen the resilience of primary health care in Latin America and the Caribbean: a modelling study.Lancet regional health. Americas · 2025Article
- Bibliometrics analysis and knowledge mapping of pertussis vaccine research: trends from 1994 to 2023.Infection · 2025Article
- Machine learning-based risk prediction model for pertussis in children: a multicenter retrospective study.BMC infectious diseases · 2025Article
- Real-World Effectiveness of 3 Types of Acellular Pertussis Vaccines Among Children Aged 3 Months-16 Years in Lu'an, China: A Matched Case-Control Study.Open forum infectious diseases · 2025Article
- Review
- Association between pertussis vaccination coverage and other sociodemographic factors and pertussis incidence using surveillance data.Epidemics · 2023Article
- Coping Strategies for Pertussis Resurgence.Vaccines · 2023Review
- Leveraging serology to titrate immunisation programme functionality for diphtheria in Madagascar.Epidemiology and infection · 2022Article
- Whole-Cell and Acellular Pertussis Vaccine: Reflections on Efficacy.Medical principles and practice : international journal of the Kuwait University, Health Science Centre · 2022Review
- Estimating Population-Level Effects of the Acellular Pertussis Vaccine Using Routinely Collected Immunization Data.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2021Article
- Durability of protection after 5 doses of acellular pertussis vaccine among 5-9 year old children in King County, Washington.Vaccine · 2021Article
- A Call for Caution in Use of Pertussis Vaccine Effectiveness Studies to Estimate Waning Immunity: A Canadian Immunization Research Network Study.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2021Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundAcellular pertussis (aP) and whole-cell (wP) pertussis vaccines are presumed to have similar short-term (<3 years after completion of the primary series) efficacy. However, vaccine effect varies between individual pertussis vaccine formulations, and many originally studied formulations are now unavailable. An updated analysis of the short-term protective effect of pertussis vaccines limited to formulations currently on the market in developed countries is needed.
methodsWe conducted a systematic review and meta-analysis of published studies that evaluated pertussis vaccine efficacy or effectiveness within 3 years after completion (>3 doses) of a primary series of a currently available aP or wP vaccine formulation. The primary outcome was based on the World Health Organization (WHO) clinical case definitions for pertussis. Study quality was assessed using the approach developed by the Child Health Epidemiology Research Group. We determined overall effect sizes using random-effects meta-analyses, stratified by vaccine (aP or wP) and study (efficacy or effectiveness) type.
resultsMeta-analysis of 2 aP vaccine efficacy studies (assessing the 3-component GlaxoSmithKline and 5-component Sanofi-Pasteur formulations) yielded an overall aP vaccine efficacy of 84% (95% confidence interval [CI], 81%-87%). Meta-analysis of 3 wP vaccine effectiveness studies (assessing the Behringwerke, Pasteur/Mérieux, and SmithKline Beecham formulations) yielded an overall wP vaccine effectiveness of 94% (95% CI, 88%-97%) (bothI(2)= 0%).
conclusionsAlthough all contemporary aP and wP formulations protect against pertussis disease, in this meta-analysis the point estimate for short-term protective effect against WHO-defined pertussis in young children was lower for currently available aP vaccines than wP vaccines.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.