ArticleThe Journal of infectious diseases2016
Global Mortality Impact of the 1957-1959 Influenza Pandemic.
Article in The Journal of infectious diseases, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 103 papers, 1 of them a synthesis that pooled it.
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Who cites it
103 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Heterogeneity in Estimates of the Impact of Influenza on Population Mortality: A Systematic Review.American journal of epidemiology · 2018Pooled it
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- Age-specific mortality patterns across influenza pandemics: evidence from all-cause mortality data across multiple populations.International journal of epidemiology · 2026Article
- Update on Influenza.The American journal of the medical sciences · 2026Review
- Emerging Respiratory Virus Threats from Influenza D and Canine Coronavirus HuPn-2018.Emerging infectious diseases · 2026Review
- Asian Flu in Milan, 1957. A brief history of the first pandemic occurred after the discovery of Influenza A virus and its impact in a large Italian city.Le infezioni in medicina · 2026Article
- Genetic characterization of influenza A viruses circulating in Hong Kong, China, 2023: the first influenza epidemic after the lifting of 2.5 years of COVID-19 non-pharmaceutical interventions.Emerging microbes & infections · 2025Article
- Antiviral Inactivated Vaccines: Looking to the Past to Face the Future-A Narrative Review.Vaccines · 2025Review
- Genetic Evolution of the Hemagglutinin Genes of Seasonal Influenza A Viruses in Türkiye Between 2017 and 2023.Influenza and other respiratory viruses · 2025Article
- Characterisation of a novel chicken-derived H3N3 avian influenza virus detected in China in 2023: Pathogenicity and immunogenicity.PloS one · 2025Article
- Reconstruction of the Discourse on Influenza During Pandemics Between 1889 and 1980 in the Predecessor Journal of Swiss Medical Weekly - A Narrative Review and Bibliometric Analysis.Public health reviews · 2025Review
- Influenza Virus Surveillance from the 1918 Influenza Pandemic to the 2020 Coronavirus Pandemic in New York State, USA.Viruses · 2024Article
- Pandemic-Proofing: Intercepting Zoonotic Spillover Events.Pathogens (Basel, Switzerland) · 2024Review
- Towards a Comprehensive Definition of Pandemics and Strategies for Prevention: A Historical Review and Future Perspectives.Microorganisms · 2024Review
- Epidemiological inference at the threshold of data availability: an influenza A(H1N2)v spillover event in the United Kingdom.Journal of the Royal Society, Interface · 2024Article
- To Be Frail or Not to Be Frail: This Is the Question-A Critical Narrative Review of Frailty.Journal of clinical medicine · 2024Review
- The Global Evolutionary History of Orf Virus in Sheep and Goats Revealed by Whole Genomes Data.Viruses · 2024Article
- An Unwanted but Long-Known Company: Post-Viral Symptoms in the Context of Past Pandemics in Switzerland (and Beyond).Public health reviews · 2024Review
43 more citing papers are in PubMed but not listed here.
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundQuantitative estimates of the global burden of the 1957 influenza pandemic are lacking. Here we fill this gap by modeling historical mortality statistics.
methodsWe used annual rates of age- and cause-specific deaths to estimate pandemic-related mortality in excess of background levels in 39 countries in Europe, the Asia-Pacific region, and the Americas. We modeled the relationship between excess mortality and development indicators to extrapolate the global burden of the pandemic.
resultsThe pandemic-associated excess respiratory mortality rate was 1.9/10,000 population (95% confidence interval [CI], 1.2-2.6 cases/10,000 population) on average during 1957-1959. Excess mortality rates varied 70-fold across countries; Europe and Latin America experienced the lowest and highest rates, respectively. Excess mortality was delayed by 1-2 years in 18 countries (46%). Increases in the mortality rate relative to baseline were greatest in school-aged children and young adults, with no evidence that elderly population was spared from excess mortality. Development indicators were moderate predictors of excess mortality, explaining 35%-77% of the variance. Overall, we attribute 1.1 million excess deaths (95% CI, .7 million-1.5 million excess deaths) globally to the 1957-1959 pandemic.
conclusionsThe global mortality rate of the 1957-1959 influenza pandemic was moderate relative to that of the 1918 pandemic but was approximately 10-fold greater than that of the 2009 pandemic. The impact of the pandemic on mortality was delayed in several countries, pointing to a window of opportunity for vaccination in a future pandemic.
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