ArticleThe Journal of infectious diseases2016
Functional Immune Cell Differences Associated With Low Vaccine Responses in Infants.
Article in The Journal of infectious diseases, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
14 citing papers in PubMed, 26 citations in OpenAlex.
- Immune Development in Early Life (IDEaL) longitudinal cohort study protocol: Identifying biomarkers of vaccine responsiveness, respiratory infection, and asthma.The journal of allergy and clinical immunology. Global · 2025Article
- Variability in Vaccine Response and Trajectory in Early Childhood and Association With Demographic Variables, Antibiotic Exposure, and Infection Proneness.The Journal of infectious diseases · 2025Article
- Respiratory infection- and asthma-prone, low vaccine responder children demonstrate distinct mononuclear cell DNA methylation pathways.Clinical epigenetics · 2024Article
- Variability of Vaccine Responsiveness in Young Children.The Journal of infectious diseases · 2024Article
- Respiratory Infection- and Asthma-prone, Low Vaccine Responder Children Demonstrate Distinct Mononuclear Cell DNA Methylation Pathways.Research square · 2024Article
- Lipidation ofInfection and immunity · 2022Article
- Antibiotic Use and Vaccine Antibody Levels.Pediatrics · 2022Article
- Infant T cells are developmentally adapted for robust lung immune responses through enhanced T cell receptor signaling.Science immunology · 2021Article
- Comparison of pneumococcal conjugate vaccine (PCV-13) cellular immune responses after primary and booster doses of vaccine.Human vaccines & immunotherapeutics · 2020Article
- Immunologic dysfunction contributes to the otitis prone condition.The Journal of infection · 2020Review
- Immune Network Modeling Predicts Specific Nasopharyngeal and Peripheral Immune Dysregulation in Otitis-Prone Children.Frontiers in immunology · 2020Article
- Computation of Robust Minimal Intervention Sets in Multi-Valued Biological Regulatory Networks.Frontiers in physiology · 2019Article
- Pneumococcal whole-cell and protein-based vaccines: changing the paradigm.Expert review of vaccines · 2017Review
- Article
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundWe sought to understand why some children respond poorly to vaccinations in the first year of life.
methodsA total of 499 children (6-36 months old) provided serum and peripheral blood mononuclear cell samples after their primary and booster vaccination. Vaccine antigen-specific antibody levels were analyzed with enzyme-linked immunosorbent assay, and frequency of memory B cells, functional T-cell responses, and antigen-presenting cell responses were assessed in peripheral blood mononuclear cell samples with flow cytometric analysis.
resultsEleven percent of children were low vaccine responders, defined a priori as those with subprotective immunoglobulin G antibody levels to ≥66% of vaccines tested. Low vaccine responders generated fewer memory B cells, had reduced activation by CD4(+) and CD8(+) T cells on polyclonal stimulation, and displayed lower major histocompatibility complex II expression by antigen-presenting cells.
conclusionsWe conclude that subprotective vaccine responses in infants are associated with a distinct immunologic profile.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.