ArticlePhysiological reports2016
Long-term patterns of urinary pyroglutamic acid in healthy humans.
Article in Physiological reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 16 citations in OpenAlex.
- Evaluation of an Infertile, All-Male ZZ Line Exhibiting Female-like Growth in Chinese Tongue Sole (Biology · 2026Article
- Impacts of aging and fluid shear stress on vascular endothelial metabolism and atherosclerosis development.Journal of biomedical science · 2025Review
- Untargeted serum metabolomics reveals novel metabolite associations and disruptions in amino acid and lipid metabolism in Parkinson's disease.Molecular neurodegeneration · 2023Article
- Role of pyroglutamic acid in cumulus cells of women with polycystic ovary syndrome.Journal of assisted reproduction and genetics · 2022Article
- Prediction of Autoimmune Diseases by Targeted Metabolomic Assay of Urinary Organic Acids.Metabolites · 2020Article
- Pyroglutamic acidosis by glutathione regeneration blockage in critical patients with septic shock.Critical care (London, England) · 2019Article
- Pyroglutamic acidosis as a cause for high anion gap metabolic acidosis: a prospective study.Scientific reports · 2019Article
- Functional Nutrition Treatment of Vulvodynia, Irritable Bowel Syndrome, and Depression: A Case Report.Integrative medicine (Encinitas, Calif.) · 2018Article
- Urinary metabolic insights into host-gut microbial interactions in healthy and IBD children.World journal of gastroenterology · 2017Article
- Long-term patterns of urinary pyroglutamic acid in healthy humans.Physiological reports · 2016Article
- Recurrent Pyroglutamic Acidosis in the Context of Undiagnosed Liver Cirrhosis-A Case Report.Journal of clinical and experimental hepatologyArticle
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
An investigation of human biological variation in urinary organic acids, including pyroglutamic acid along with 39 other compounds, was previously reported in which levels were determined for 8 weeks in healthy adult subjects. Here, unique, 4-week-long physiological trends for one of those compounds, pyroglutamic acid (PGA), are reported. When PGA levels for an individual rose above 40 μg/mg creatinine, 4-week downward progressions occurred until levels reached values near 15 μg/mg creatinine and the pattern was reversed when levels for an individual were below that level in the early weeks of the study. The pattern was especially prominent among 8 of the 13 menstruating female subjects suggesting a possible association with metabolic stress of the menstrual cycle. However, it also appeared in 3 of the 8 male subjects where other sources of metabolic stress may be present. The menstrual association is consistent with estrogen-mediated increase in oxidative stress. Since PGA is linked to glutathione turnover, the consistency of extreme values across all individuals displaying the pattern indicates that 15 and 40 μg/mg creatinine may represent limits that trigger shifts in sulfur amino acid metabolism. This is the first observation of approximate month-long cyclic responses in a glutathione-related urinary marker in humans.
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