Evidence map›Paper›PMID 26908690›Full record

ArticlePediatrics2016

Vaccination and 30-Day Mortality Risk in Children, Adolescents, and Young Adults.

Natalie L McCarthy, Julianne Gee, Lakshmi Sukumaran, Eric Weintraub, Jonathan Duffy, Elyse O Kharbanda, Roger Baxter, Stephanie Irving, Jennifer King, Matthew F Daley and 2 more

Open access · greenAbstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Pediatrics, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
2.1field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it, 12 citations in OpenAlex.

  1. Prevention of Pertussis, Tetanus, and Diphtheria with Vaccines in the United States: Recommendations of the Advisory Committee on Immunization Practices (ACIP).MMWR. Recommendations and reports : Morbidity and mortality weekly report. Recommendations and reports · 2018
    Guideline
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  3. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 5 institutions in 1 country.

Natalie L McCarthyCenters for Disease Control and Prevention, Atlanta, Georgia; nmccarthy@cdc.gov.
Julianne GeeCenters for Disease Control and Prevention, Atlanta, Georgia;
Lakshmi SukumaranCenters for Disease Control and Prevention, Atlanta, Georgia; Department of Pediatrics, Emory University School of Medicine, Atlanta, Georgia;
Eric WeintraubCenters for Disease Control and Prevention, Atlanta, Georgia;
Jonathan DuffyCenters for Disease Control and Prevention, Atlanta, Georgia;
Elyse O KharbandaHealthPartners Institute for Education and Research, Minneapolis, Minnesota;
Roger BaxterKaiser Permanente of Northern California, Oakland, California;
Stephanie IrvingKaiser Permanente Northwest, Portland, Oregon;
Jennifer KingMarshfield Clinic Research Foundation, Marshfield, Wisconsin;
Matthew F DaleyInstitute for Health Research, Kaiser Permanente Colorado, Denver, Colorado; and.
Rulin HechterKaiser Permanente Southern California, Pasadena, California.
Michael M McNeilCenters for Disease Control and Prevention, Atlanta, Georgia;
Centers for Disease Control and Prevention · USKaiser Permanente · USEmory University · USHealthPartners · USMarshfield Clinic · US

Funding

Training a New Generation of VaccinologistsT32AI074492 · NIAID · EMORY UNIVERSITY · PI Rama Rao Amara, Benjamin A Lopman · 2009 to 2026
$6.4M
Intramural CDC HHS CC999999NIAID NIH HHS T32 AI074492NIAID NIH HHS T32AI074492PHS HHS 00-2012-53580
6 · The paper itself

Abstract

objectiveThis study evaluates the potential association of vaccination and death in the Vaccine Safety Datalink (VSD).

methodsThe study cohort included individuals ages 9 to 26 years with deaths between January 1, 2005, and December 31, 2011. We implemented a case-centered method to estimate a relative risk (RR) for death in days 0 to 30 after vaccination.Deaths due to external causes (accidents, homicides, and suicides) were excluded from the primary analysis. In a secondary analysis, we included all deaths regardless of cause. A team of physicians reviewed available medical records and coroner's reports to confirm cause of death and assess the causal relationship between death and vaccination.

resultsOf the 1100 deaths identified during the study period, 76 (7%) occurred 0 to 30 days after vaccination. The relative risks for deaths after any vaccination and influenza vaccination were significantly lower for deaths due to nonexternal causes (RR 0.57, 95% confidence interval [CI] 0.38-0.83, and RR 0.44, 95% CI 0.24-0.80, respectively) and deaths due to all causes (RR 0.72, 95% CI 0.56-0.91, and RR 0.44, 95% CI 0.28-0.65). No other individual vaccines were significantly associated with death. Among deaths reviewed, 1 cause of death was unknown, 25 deaths were due to nonexternal causes, and 34 deaths were due to external causes. The causality assessment found no evidence of a causal association between vaccination and death.

conclusionsRisk of death was not increased during the 30 days after vaccination, and no deaths were found to be causally associated with vaccination.

Indexed as

AdolescentAdultCause of DeathChildFemaleFollow-Up StudiesHumansMalePopulation SurveillanceRetrospective StudiesRisk AssessmentSurvival RateTime FactorsUnited StatesVaccinationYoung Adult

Identifiers

PMID26908690
PMCPMC6511986
OpenAlexW2318705932

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.