Evidence map›Paper›PMID 26908669›Full record

ArticlePediatrics2016

Risk of Cancer in Children Conceived by Assisted Reproductive Technology.

Marte Myhre Reigstad, Inger Kristin Larsen, Tor Åge Myklebust, Trude Eid Robsahm, Nan Birgitte Oldereid, Louise A Brinton, Ritsa Storeng

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pediatrics, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed, 4 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 4 syntheses or guidelines pooled it.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

Marte Myhre ReigstadNorwegian National Advisory Unit on Women's Health and Cancer Registry of Norway, Institute of Population-Based Cancer Research, Oslo, Norway; and martereigstad@gmail.com.
Inger Kristin LarsenCancer Registry of Norway, Institute of Population-Based Cancer Research, Oslo, Norway; and.
Tor Åge MyklebustCancer Registry of Norway, Institute of Population-Based Cancer Research, Oslo, Norway; and.
Trude Eid RobsahmCancer Registry of Norway, Institute of Population-Based Cancer Research, Oslo, Norway; and.
Nan Birgitte OldereidSection for Reproductive Medicine, Department of Gynecology, Oslo University Hospital, Rikshospitalet, Oslo, Norway;
Louise A BrintonDivision of Cancer Epidemiology & Genetics, Hormonal and Reproductive Epidemiology Branch, National Cancer Institute, Bethesda, Maryland.
Ritsa StorengNorwegian National Advisory Unit on Women's Health and.

Funding

Therapeutic and Diagnostic Factors as Related to Cancer RiskZIACP010128 · NCI · DIVISION OF CANCER EPIDEMIOLOGY AND GENETICS · PI GIERACH, GRETCHEN · 2009 to 2025
$8.1M
Therapeutic &Diagnostic Factors Related to Cancer RisKZ01CP010128 · NCI · DIVISION OF CANCER EPIDEMIOLOGY AND GENETICS · PI BRINTON, LOUISE · 1996 to 2008
$146k
Intramural NIH HHS Z01 CP010128
6 · The paper itself

Abstract

BACKGROUND AND

objectiveAn increasing number of children are born after assisted reproductive technology (ART), and monitoring their long-term health effects is of interest. This study compares cancer risk in children conceived by ART to that in children conceived without.

methodsThe Medical Birth Registry of Norway contains individual information on all children born in Norway (including information of ART conceptions). All children born between 1984 and 2011 constituted the study cohort, and cancer data were obtained from the Cancer Registry of Norway. Follow-up started at date of birth and ended on the date of the first cancer diagnosis, death, emigration, or December 31, 2011. A Cox proportional hazards model was used to calculate hazard ratios (HR) and 95% confidence intervals (CI) of overall cancer risk between children conceived by ART and those not. Cancer risk was also assessed separately for all childhood cancer types.

resultsThe study cohort comprised 1 628 658 children, of which 25 782 were conceived by ART. Of the total 4554 cancers, 51 occurred in ART-conceived children. Risk of overall cancer was not significantly elevated (HR 1.21; 95% CI 0.90-1.63). However, increased risk of leukemia was observed for children conceived by ART compared with those who were not (HR 1.67; 95% CI 1.02-2.73). Elevated risk of Hodgkin's lymphoma was also found for ART-conceived children (HR 3.63; 95% CI 1.12-11.72), although this was based on small numbers.

conclusionsThis population-based cohort study found elevated risks of leukemia and Hodgkin's lymphoma in children conceived by ART.

Indexed as

Reproductive Techniques, AssistedAdolescentCentral Nervous System NeoplasmsChildChild, PreschoolFemaleHodgkin DiseaseHumansInfantLeukemiaMaleNeoplasmsNorwayRegistriesRisk Factors

Identifiers

PMID26908669
PMCPMC5178823

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.