ArticlePediatrics2016
Assisted Reproductive Technology and Early Intervention Program Enrollment.
Article in Pediatrics, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it, 11 citations in OpenAlex.
- Exposure to non-persistent chemicals in consumer products and fecundability: a systematic review.Human reproduction update · 2019Pooled it
- Subfecundity, Infertility Treatment, and Child Neurodevelopment.JAMA network open · 2026Article
- Article
- Length of Stay Among Infants with Neonatal Abstinence Syndrome and Risk of Hospital Readmission.Maternal and child health journal · 2022Article
- Early Autism Spectrum Disorders in Children Born to Fertile, Subfertile, and ART-Treated Women.Maternal and child health journal · 2019Article
- Length of stay and cost of birth hospitalization: effects of subfertility and ART.Journal of perinatology : official journal of the California Perinatal Association · 2018Article
- Adverse pregnancy, birth, and infant outcomes in twins: effects of maternal fertility status and infant gender combinations; the Massachusetts Outcomes Study of Assisted Reproductive Technology.American journal of obstetrics and gynecology · 2017Article
- Pregnancy, birth, and infant outcomes by maternal fertility status: the Massachusetts Outcomes Study of Assisted Reproductive Technology.American journal of obstetrics and gynecology · 2017Article
- Perinatal outcomes of singleton siblings: the effects of changing maternal fertility status.Journal of assisted reproduction and genetics · 2016Article
- Is the wrong question being asked in infertility research?Journal of assisted reproduction and genetics · 2016Article
- Early Intervention Referral and Enrollment Among Infants with Neonatal Abstinence Syndrome.Journal of developmental and behavioral pediatrics : JDBPArticle
- Early Intervention Enrollment Among Substance-exposed Infants in Massachusetts: A Population-level Analysis.Journal of developmental and behavioral pediatrics : JDBPArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 5 institutions in 1 country.
Funding
Abstract
objectivesWe examined the prevalence of Early Intervention (EI) enrollment in Massachusetts comparing singleton children conceived via assisted reproductive technology (ART), children born to mothers with indicators of subfertility but no ART (Subfertile), and children born to mothers who had no indicators of subfertility and conceived naturally (Fertile). We assessed the natural direct effect (NDE), the natural indirect effect (NIE) through preterm birth, and the total effect of ART and subfertility on EI enrollment.
methodsWe examined maternal and infant characteristics among singleton ART (n = 6447), Subfertile (n = 5515), and Fertile (n = 306,343) groups and characteristics associated with EI enrollment includingpreterm birth using χ(2) statistics (α = 0.05). We estimated the NDE and NIE of the ART-EI enrollment relationship by fitting a model for enrollment, conditional on ART, preterm and the ART-preterm delivery interaction, and covariates. Similar analyses were conducted by using Subfertile as the exposure.
resultsThe NDE indicated that the odds of EI enrollment were 27% higher among the ART group (odds ratioNDE = 1.27; 95% confidence interval (CI): 1.19 ̶ 1.36) and 20% higher among the Subfertilegroup (odds ratioNDE = 1.20; 95% CI: 1.12 ̶ 1.29) compared with the Fertile group, even if the rate of preterm birth is held constant.
conclusionsSingleton children conceived through ART and children of subfertile mothers both have elevated risks of EI enrollment. These findings have implications for clinical providers as they counsel women about child health outcomes associated with ART or subfertility.
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Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.