Evidence map›Paper›PMID 26908421›Full record

ArticleEuropean journal of clinical nutrition2016

Association of adherence to a Mediterranean diet with glycemic control and cardiovascular risk factors in youth with type I diabetes: the SEARCH Nutrition Ancillary Study.

V W Zhong, A P Lamichhane, J L Crandell, S C Couch, A D Liese, N S The, B A Tzeel, D Dabelea, J M Lawrence, S M Marcovina and 2 more

Abstract read
In one paragraph

Article in European journal of clinical nutrition, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed, 1 pooled it
3.6field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

35 citing papers in PubMed, 1 synthesis or guideline pooled it, 73 citations in OpenAlex.

  1. Pooled it
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  14. Dietary treatment of type 1 diabetes - once upon a time versus today.Pediatric endocrinology, diabetes, and metabolism · 2023
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 8 institutions in 1 country.

V W ZhongDepartment of Nutrition, University of North Carolina, Chapel Hill, NC, USA.
A P LamichhaneDepartment of Nutrition, University of North Carolina, Chapel Hill, NC, USA.
J L CrandellSchool of Nursing and Department of Biostatistics, University of North Carolina, Chapel Hill, NC, USA.
S C CouchDepartment of Nutritional Sciences, University of Cincinnati, Cincinnati, OH, USA.
A D LieseDepartment of Epidemiology and Biostatistics, University of South Carolina, Columbia, SC, USA.
N S TheDepartment of Health Sciences, Furman University, Greenville, SC, USA.
B A TzeelDepartment of Nutrition, University of North Carolina, Chapel Hill, NC, USA.
D DabeleaDepartment of Epidemiology, University of Colorado, Denver, CO, USA.
J M LawrenceDepartment of Research and Evaluation, Kaiser Permanente Southern California, Pasadena, CA, USA.
S M MarcovinaDepartment of Medicine, University of Washington, Seattle, WA, USA.
G KimSeattle Children's Hospital, Seattle, WA, USA.
E J Mayer-DavisDepartment of Nutrition, University of North Carolina, Chapel Hill, NC, USA.
University of North Carolina at Chapel Hill · USFurman University · USKaiser Permanente · USSeattle Children's Hospital · USUniversity of Cincinnati · USUniversity of Colorado Denver · USUniversity of South Carolina · USUniversity of Washington · US

Funding

UNIV OF NORTH CAROLINA CLINICAL NUTRITION RESEARCH UNITP30DK056350 · NIDDK · UNIV OF NORTH CAROLINA CHAPEL HILL · PI SUSAN M. SMITH · 1999 to 2026
$31.6M
SEARCH Nutrition Ancillary Study 2R01DK077949 · NIDDK · UNIV OF NORTH CAROLINA CHAPEL HILL · PI MAYER-DAVIS, ELIZABETH J, THE, NATALIE · 2008 to 2017
$5.4M
NUTRITION TRAINING PROGRAMT32DK007686 · NIDDK · UNIV OF NORTH CAROLINA CHAPEL HILL · PI BECK, MELINDA A., MAYER-DAVIS, ELIZABETH J · 1992 to 2022
$4.3M
HSRD VA HIR 10-001NIDDK NIH HHS P30 DK056350NIDDK NIH HHS R01 DK077949NIDDK NIH HHS T32 DK007686
6 · The paper itself

Abstract

BACKGROUND/

objectivesThis study aimed to determine the association between a Mediterranean diet and glycemic control and other cardiovascular risk factors among youth with type I diabetes (TID). SUBJECTS/

methodsIncident TID cases aged <20 years at diagnosis between 2002 and 2005 were included. Participants were seen at baseline (N=793), 1-year (N=512) and 5-year follow-up visits (N=501). Mediterranean diet score was assessed using a modified KIDMED index (mKIDMED). Multivariate linear regression and longitudinal mixed model were applied to determine the association between mKIDMED score and log-HbA1c, lipids, blood pressure (BP) and obesity.

resultsIn cross-sectional analyses using baseline data, for individuals with the hemoglobin A1c (HbA1c) of 7.5%, a two-point higher mKIDMED score (1 s.d.) was associated with 0.15% lower HbA1c (P=0.02). A two-point higher mKIDMED score was associated with 4.0 mg/dl lower total cholesterol (TC) (P=0.006), 3.4 mg/dl lower low-density lipoprotein cholesterol (LDL-C) (P=0.004), 3.9 mg/dl lower non-high-density lipoprotein cholesterol (non-HDL-C) (P=0.004) and 0.07 lower LDL-C/HDL-C ratio (P=0.02). Using longitudinal data, a two-point increase in mKIDMED score was associated with 0.01% lower log-HbA1c (P=0.07), 1.8 mg/dl lower TC (P=0.05), 1.6 mg/dl lower LDL-C (P=0.03) and 1.8 mg/dl lower non-HDL-C (P=0.03) than would otherwise have been expected. HbA1c mediated ∼20% of the association for lipids in both cross-sectional and longitudinal models. An unexpected positive association between mKIDMED score and systolic BP was found among non-Hispanic white youth in cross-sectional analyses (P=0.009). Mediterranean diet was not associated with obesity.

conclusionsMediterranean diet may improve glycemic control and cardiovascular health in TID youth.

Indexed as

Diet, MediterraneanFeeding BehaviorAdolescentAdultBlood GlucoseBlood PressureCardiovascular DiseasesChildChild, PreschoolCross-Sectional StudiesDiabetes Mellitus, Type 1FemaleFollow-Up StudiesGlycated HemoglobinHumansInsulinBlood GlucoseGlycated HemoglobinInsulinLipidsLipoproteins

Identifiers

PMID26908421
PMCPMC4935596
OpenAlexW2287379882

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.