SynthesisBritish journal of cancer2016
Contribution of mammography to MRI screening in BRCA mutation carriers by BRCA status and age: individual patient data meta-analysis.
Synthesis in British journal of cancer, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
47 citing papers in PubMed, 3 syntheses or guidelines pooled it, 116 citations in OpenAlex.
- A systematic review of recommendations on screening strategies for breast cancer due to hereditary predisposition: Who, When, and How?Cancer medicine · 2021Pooled it
- Cost-Effectiveness Analysis of Imaging Modalities for Breast Cancer Surveillance AmongFrontiers in oncology · 2021Pooled it
- Breast Cancer Screening: Updated Recommendations of the Brazilian College of Radiology and Diagnostic Imaging, Brazilian Breast Disease Society, and Brazilian Federation of Gynecological and Obstetrical Associations.Revista brasileira de ginecologia e obstetricia : revista da Federacao Brasileira das Sociedades de Ginecologia e Obstetricia · 2017Guideline
- Comparison of High-Risk Breast Cancer Screenings with Concurrent Versus Staggered Breast MRI and Mammogram Schedules.Journal of clinical medicine · 2026Article
- Breast Imaging Reporting and Data System v2025: Key Updates in Mammography.Journal of the Korean Society of Radiology · 2026Review
- Review
- Diagnostic sensitivity of mammography and magnetic resonance imaging for ductal carcinomaChinese journal of cancer research = Chung-kuo yen cheng yen chiu · 2025Article
- Does the Addition of MRI Help in Breast Cancer Detection in Women with Low Breast Tissue Density in Two Canadian Population-based High-Risk Breast Screening Programs?Radiology. Imaging cancer · 2025Article
- The TESTBREAST journey: Revisiting the importance of early detection by frequent screening of women at high risk of breast cancer.International journal of cancer · 2025Article
- High risk surveillance MRI may not be necessary in BRCA1/2 mutation carriers over 70 years old.Breast cancer research and treatment · 2025Article
- Exploring MRI and Mammography Lesion Features for Breast Cancer Detection in PTEN Hamartoma Tumor Syndrome.Cancers · 2025Article
- Advances in Risk Management and Screening for Women at Increased Risk of Breast Cancer: The Role of MR Imaging and Personalised Approaches.Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine · 2025Review
- Recommendations for the Screening of Breast Cancer of the Brazilian College of Radiology and Diagnostic Imaging, Brazilian Society of Mastology and Brazilian Federation of Gynecology and Obstetrics Association.Revista brasileira de ginecologia e obstetricia : revista da Federacao Brasileira das Sociedades de Ginecologia e Obstetricia · 2023Article
- Uptake of BRCA1/BRCA2 predictive genetic testing in an Irish population is low: a missed opportunity.Irish journal of medical science · 2023Article
- Deep learning for predicting future lesion emergence in high-risk breast MRI screening: a feasibility study.European radiology experimental · 2023Article
- Data Do Not Support Semiannual Screening US after MRI, and Screening Mammography after MRI Has Limited Benefit.Radiology · 2023Article
- Breast MRI: Clinical Indications, Recommendations, and Future Applications in Breast Cancer Diagnosis.Current oncology reports · 2023Review
- Controversies and Open Questions in Management of Cancer-Free Carriers of Germline Pathogenic Variants inCancers · 2022Review
- Prevalent versus incident breast cancers: benefits of clinical and radiological monitoring in women with pathogenic BRCA1/2 variants.European journal of human genetics : EJHG · 2022Article
- The yield and effectiveness of breast cancer surveillance in women with PTEN Hamartoma Tumor Syndrome.Cancer · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
16 authors at 14 institutions in 6 countries.
Funding
Abstract
backgroundWe investigated the additional contribution of mammography to screening accuracy in BRCA1/2 mutation carriers screened with MRI at different ages using individual patient data from six high-risk screening trials.
methodsSensitivity and specificity of MRI, mammography and the combination of these tests were compared stratified for BRCA mutation and age using generalised linear mixed models with random effect for studies. Number of screens needed (NSN) for additional mammography-only detected cancer was estimated.
resultsIn BRCA1/2 mutation carriers of all ages (BRCA1 = 1,219 and BRCA2 = 732), adding mammography to MRI did not significantly increase screening sensitivity (increased by 3.9% in BRCA1 and 12.6% in BRCA2 mutation carriers, P > 0.05). However, in women with BRCA2 mutation younger than 40 years, one-third of breast cancers were detected by mammography only. Number of screens needed for mammography to detect one breast cancer not detected by MRI was much higher for BRCA1 compared with BRCA2 mutation carriers at initial and repeat screening.
conclusionsAdditional screening sensitivity from mammography above that from MRI is limited in BRCA1 mutation carriers, whereas mammography contributes to screening sensitivity in BRCA2 mutation carriers, especially those ⩽ 40 years. The evidence from our work highlights that a differential screening schedule by BRCA status is worth considering.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.