ArticleBritish journal of cancer2016
Analgesic medication use and risk of epithelial ovarian cancer in African American women.
Article in British journal of cancer, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 2 syntheses or guidelines pooled it, 26 citations in OpenAlex.
- Modification of the Association Between Frequent Aspirin Use and Ovarian Cancer Risk: A Meta-Analysis Using Individual-Level Data From Two Ovarian Cancer Consortia.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2022Pooled it
- Associations between aspirin use and the risk of cancers: a meta-analysis of observational studies.BMC cancer · 2018Pooled it
- Aspirin use and ovarian cancer risk using extended follow-up of the PLCO Cancer Screening Trial.Gynecologic oncology · 2020Trial
- Longer-term aspirin use and subsequent ovarian cancer risk in the Ovarian Cancer Cohort Consortium.International journal of epidemiology · 2026Article
- Use of non-prescription analgesic medications and survival among Black women with ovarian cancer.British journal of cancer · 2026Article
- Low-dose aspirin use and risk of ovarian cancer: a combined analysis from two nationwide studies in Denmark and Sweden.British journal of cancer · 2024Article
- Assessment of gynecological and lifestyle-related risk factors of ovarian cancer.Przeglad menopauzalny = Menopause review · 2021Article
- Aspirin inhibits tumor progression and enhances cisplatin sensitivity in epithelial ovarian cancer.PeerJ · 2021Article
- Urinary PGE-M Levels and Risk of Ovarian Cancer.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2019Article
- Ovarian Cancer in Women of African Ancestry (OCWAA) consortium: a resource of harmonized data from eight epidemiologic studies of African American and white women.Cancer causes & control : CCC · 2019Article
- Dual Actions of Ketorolac in Metastatic Ovarian Cancer.Cancers · 2019Review
- A review of the effects of healthcare disparities on the experience and survival of ovarian cancer patients of different racial and ethnic backgrounds.Journal of cancer metastasis and treatment · 2019Article
- Association of Analgesic Use With Risk of Ovarian Cancer in the Nurses' Health Studies.JAMA oncology · 2018Article
- Anti-Inflammatory Drug Use and Ovarian Cancer Risk by COX1/COX2 Expression and Infiltration of Tumor-Associated Macrophages.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2018Article
- Review
- Racial/ethnic differences in the epidemiology of ovarian cancer: a pooled analysis of 12 case-control studies.International journal of epidemiology · 2018Article
- Racial health disparities in ovarian cancer: not just black and white.Journal of ovarian research · 2017Review
- Lifetime number of ovulatory cycles and epithelial ovarian cancer risk in African American women.Cancer causes & control : CCC · 2017Article
- Epidemiology of ovarian cancer: a review.Cancer biology & medicine · 2017Article
- Dietary inflammatory index and risk of epithelial ovarian cancer in African American women.International journal of cancer · 2017Article
Corrections and comments
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Authors and funding
16 authors at 12 institutions in 1 country.
Funding
Abstract
backgroundExisting literature examining analgesic medication use and epithelial ovarian cancer (EOC) risk has been inconsistent, with the majority of studies reporting an inverse association. Race-specific effects of this relationship have not been adequately addressed.
methodsUtilising data from the largest population-based case-control study of EOC in African Americans, the African American Cancer Epidemiology Study, the relationship between analgesic use (aspirin, non-aspirin nonsteroidal anti-inflammatory drugs (NSAIDs), and acetaminophen) and risk of EOC was estimated by multivariate logistic regression. The association of frequency, duration, and indication of analgesic use on EOC risk was also assessed.
resultsAspirin use, overall, was associated with a 44% lower EOC risk (OR=0.56; 95% CI=0.35-0.92) and a 26% lower EOC risk was observed for non-aspirin NSAID use (OR=0.74; 95% CI=0.52-1.05). The inverse association was strongest for women taking aspirin to prevent cardiovascular disease and women taking non-aspirin NSAIDs for arthritis. Significantly decreased EOC risks were observed for low-dose aspirin use, daily aspirin use, aspirin use for <5 years, and occasional non-aspirin NSAID use for a duration of ⩾5 years. No association was observed for acetaminophen use.
conclusionsCollectively, these findings support previous evidence that any NSAID use is inversely associated with EOC risk.
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