ArticleScientific reports2016
Characterization of a novel Achromobacter xylosoxidans specific siphoviruse: phiAxp-1.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 22 citations in OpenAlex.
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- Evaluation of Phage Therapy for Pulmonary Infection of Mouse by Liquid Aerosol-ExposureInfection and drug resistance · 2021Article
- Characterization of Novel Lytic Bacteriophages ofViruses · 2020Article
- Therapeutic Characterization and Efficacy of Bacteriophage Cocktails InfectingFrontiers in microbiology · 2019Article
- Characterization of Two Novel Bacteriophages Infecting Multidrug-Resistant (MDR)Frontiers in microbiology · 2018Article
- Identification and molecular characterization of bacteriophage phiAxp-2 of Achromobacter xylosoxidans.Scientific reports · 2016Article
- Isolation and characterization of a bacteriophage phiEap-2 infecting multidrug resistant Enterobacter aerogenes.Scientific reports · 2016Article
- Isolation and molecular characterisation of Achromobacter phage phiAxp-3, an N4-like bacteriophage.Scientific reports · 2016Article
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14 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Bacteriophages have recently been considered as an alternative biocontrol tool because of the widespread occurrence of antimicrobial-resistant Achromobacter xylosoxidans. Herein, we isolated a virulent bacteriophage (phiAxp-1) from a water sample of the Bohai sea of China that specifically infects A. xylosoxidans. Transmission electron microscopy revealed that phage phiAxp-1 belongs to the Siphoviridae. We sequenced the genome of phiAxp-1, which comprises 45,045 bp with 64 open reading frames. Most of the proteins encoded by phiAxp-1 have no similarity to sequences in the public databases. Twenty-one proteins with assigned functions share weak homology with those of other dsDNA bacteriophages infecting diverse hosts, such as Burkholderia phage KL1, Pseudomonas phage 73, Pseudomonas phage vB_Pae-Kakheti25, Pseudomonas phage vB_PaeS_SCH_Ab26, Acinetobacter phage IME_AB3 and Achromobacter phage JWX. The genome can be divided into different clusters for the head and tail structure, DNA replication and mazG. The sequence and genomic organization of bacteriophage phiAxp-1 are clearly distinct from other known Siphoviridae phages; therefore, we propose that it is a member of a novel genus of the Siphoviridae family. Furthermore, one-step growth curve and stability studies of the phage were performed, and the specific receptor of phiAxp-1 was identified as the lipopolysaccharide of A. xylosoxidans.
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