Evidence map›Paper›PMID 26908216›Full record

ArticleClinical biochemistry2016

Cut-off levels for hyperandrogenemia among Samoan women: An improved methodology for deriving normative data in an obese population.

Hasina Maredia, Geralyn M Lambert-Messerlian, Glenn E Palomaki, Satupaitea Viali, Nicola L Hawley, Stephen T McGarvey

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PubMed Full text at PMC Publisher
In one paragraph

Article in Clinical biochemistry, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.7field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Article
  3. Serum anti-mullerian hormone levels and age among Samoan women.Reproductive biology and endocrinology : RB&E · 2025
    Article
  4. Article
  5. Reproductive health, obesity, and cardiometabolic risk factors among Samoan women.American journal of human biology : the official journal of the Human Biology Council · 2018
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

Hasina MarediaDepartment of Pathology and Laboratory Medicine, Alpert Medical School of Brown University, Providence, RI 02912, USA; Department of Epidemiology and International Health Institute, Brown University School of Public Health, Providence, RI 02912, USA. Electronic address: HasinaMaredia@gmail.com.
Geralyn M Lambert-MesserlianDepartment of Pathology and Laboratory Medicine, Alpert Medical School of Brown University, Providence, RI 02912, USA.
Glenn E PalomakiDepartment of Pathology and Laboratory Medicine, Alpert Medical School of Brown University, Providence, RI 02912, USA.
Satupaitea VialiNational University of Samoa, Apia, Samoa.
Nicola L HawleyDepartment of Chronic Disease Epidemiology, Yale School of Public Health, New Haven, CT 06520, USA.
Stephen T McGarveyDepartment of Epidemiology and International Health Institute, Brown University School of Public Health, Providence, RI 02912, USA.
Brown University · USNational University of Samoa · WSYale University · US

Funding

Integrated cellular, mouse and human research on a novel missense variant influencing adiposity in SamoansR01HL093093 · NHLBI · BROWN UNIVERSITY · PI MCGARVEY, STEPHEN T. · 2009 to 2019
$8.2M
NHLBI NIH HHS R01 HL093093
6 · The paper itself

Abstract

objectiveTo define biochemical hyperandrogenemia (HA) among a population-based sample of reproductive-aged Samoan women, taking into consideration their high BMI levels. DESIGN AND

methodsA secondary analysis was performed among a cross-sectional sample of Samoan women aged 25-39years (n=494) who were part of a larger genome-wide association study (GWAS) of adiposity. Women indicating pregnancy/lactation, hysterectomy, oophorectomy, cancer treatment, or use of contraceptive injections were excluded from the study. We analyzed the distribution of free androgen index (FAI) values to establish normative androgen data among Samoan women of reproductive age. Using the lowest tertile of body mass index (BMI), we defined HA as free androgen index (FAI) values >95(th) FAI percentile in that subsample. We compared the anthropometric and metabolic characteristics of women with HA to women with normal androgen levels.

resultsHA was defined as FAI>8.5. Using this definition, 14% of women were classified as hyperandrogenemic. Women with HA had significantly higher average BMI values, abdominal circumferences, fasting triglycerides, and insulin levels as well as significantly lower adiponectin levels.

conclusionThis study is the first to define normative androgen values among Samoan women with a quantitative assessment of the relationship between adiposity and androgen levels. The uniquely high BMI levels in the population not only provide important clinical insight into normative androgen values among Samoan women, but they also serve as references for the clinical assessment of HA, taking into consideration BMI, in other populations.

Indexed as

AdiponectinAdiposityAdultAgedAndrogensAnthropometryBiomarkersBody Mass IndexCross-Sectional StudiesFemaleFollow-Up StudiesHumansHyperandrogenismMiddle AgedObesityPrevalenceAdiponectinADIPOQ protein, humanAndrogensBiomarkersTriglyceridesAndrogensBody mass indexObesitySamoa

Identifiers

PMID26908216
PMCPMC4915982
OpenAlexW2273611928

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.