ArticleSoft matter2016
Local dynamic mechanical analysis for heterogeneous soft matter using ferrule-top indentation.
Article in Soft matter, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed.
- Viscoelastic Hydrogels Governed by Molecular Interactions and Mechanochemical Effects.Polymers · 2026Review
- Plectin affects cell viscoelasticity at small and large deformations.Biophysical journal · 2026Article
- Kinetically Frozen Rheology of Agar-agar Hydrogels Upon a Change of Anions in the Hofmeister Series.Macromolecular rapid communications · 2025Article
- The enteric nervous system is 10 times stiffer than the brain.Biophysical journal · 2025Article
- Human adipose stromal cells differentiate towards a tendon phenotype with adapted visco-elastic properties in a 3D-culture system.Biology open · 2025Article
- The extracellular matrix mechanics in the vasculature.Nature cardiovascular research · 2023Review
- Crosslinking of Bovine Gelatin Gels by Genipin Revisited Using Ferrule-Top Micro-Indentation.Gels (Basel, Switzerland) · 2023Article
- Viscoelastic Biomaterials for Tissue Regeneration.Tissue engineering. Part C, Methods · 2022Review
- Voltage-Driven Alterations to Neuron Viscoelasticity.Bioelectricity · 2022Article
- Parallel-plate compression test for soft materials: confocal microscopy-assisted ferrule-top nanoindentation.Biomedical optics express · 2022Article
- Indentation probe with optical fibre array-based optical coherence tomography for material deformation.Journal of microscopy · 2021Article
- Accounting for Material Changes in Decellularized Tissue with Underutilized Methodologies.BioMed research international · 2021Review
- In vivo characterization of chick embryo mesoderm by optical coherence tomography-assisted microindentation.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2020Article
- Lab-On-Fiber Technology: A Roadmap toward Multifunctional Plug and Play Platforms.Sensors (Basel, Switzerland) · 2020Review
- Investigating the Effects of Mechanical Stimulation on Retinal Ganglion Cell Spontaneous Spiking Activity.Frontiers in neuroscience · 2019Article
- Comparison of frequency and strain-rate domain mechanical characterization.Scientific reports · 2018Article
- Regional variations in stiffness in live mouse brain tissue determined by depth-controlled indentation mapping.Scientific reports · 2018Article
- Opto-mechanical lab-on-fibre seismic sensors detected the Norcia earthquake.Scientific reports · 2018Article
- Stiffening of the nucleus pulposus upon axial loading of the intervertebral disc: An experimental in situ study.JOR spine · 2018Article
- Minimally Invasive Micro-Indentation: mapping tissue mechanics at the tip of an 18G needle.Scientific reports · 2017Article
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
There is a strong demand for nanoindentation methods to probe the heterogeneous viscoelastic properties of soft tissues. Important applications include diagnosis of early onset diseases such as arthritis and investigations into cellular mechanoresponse in tissue. Quantification of tissue mechanics at length and time scales relevant to biological processes, however, remains a technical challenge. Here, we present a new nanoindentation approach that is ideally suited to probe the viscoelastic properties of soft, hydrated tissues. We built a ferrule-top probe that uses wavelength modulation in a Fabry-Pérot cavity configuration to detect cantilever deflection and to drive a feedback-controlled piezoelectric actuator. This technique allows us to control the static load applied onto the sample using an all-optical mm-sized probe. We extract the local elastic and viscous moduli of the samples by superposing a small oscillatory load and recording the indentation depth at the frequency of oscillation. By using a set of silicone elastomers with a range of stiffnesses representative of biological tissues, we demonstrate that the technique can accurately determine moduli over a wide range (0.1-100 kPa) and over a frequency range of 0.01-10 Hz. Direct comparison with macroscopic rheology measurements yields excellent quantitative agreement, without any fitting parameters. Finally, we show how this method can provide a spatially-resolved map of large variations in mechanical properties (orders of magnitude) across the surface of soft samples thanks to high sensitivity over large (>μm) cantilever deflections. This approach paves the way to investigations into the local dynamic mechanical properties of biological soft matter.
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