ArticleAsian journal of andrology
Y-chromosome microdeletions in nonobstructive azoospermia and severe oligozoospermia.
Article in Asian journal of andrology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 2 of them syntheses that pooled it.
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Who cites it
28 citing papers in PubMed, 2 syntheses or guidelines pooled it, 59 citations in OpenAlex.
- FertilitY Predictor-a machine learning-based web tool for the prediction of assisted reproduction outcomes in men with Y chromosome microdeletions.Journal of assisted reproduction and genetics · 2025Pooled it
- Reproductive outcomes of intracytoplasmic sperm injection using testicular sperm and ejaculated sperm in patients with AZFc microdeletions: a systematic review and meta-analysis.Asian journal of andrologyPooled it
- Review
- Comment on "the FertilitY predictor under scrutiny: a call for reassessment of methodological and biological flaws".Journal of assisted reproduction and genetics · 2026Article
- Oocyte maturation triggers in high-responders: a report on 1,217 consecutive cycles.Reproduction & fertility · 2025Article
- Medical treatment prior to micro-TESE.Asian journal of andrology · 2025Review
- Clinical predictors of successful outcomes for couples with nonobstructive azoospermic male partners undergoing micro-TESE.Asian journal of andrology · 2025Review
- Association of Y chromosome AZF region microdeletions with recurrent miscarriage in Iranian couples: A case-control study.Molecular genetics & genomic medicine · 2024Article
- Independent factors associated with intracytoplasmic sperm injection outcomes in patients with complete azoospermia factor c microdeletions.Human reproduction open · 2024Article
- First report of frequencies of Y chromosome microdeletions at a reproductive medicine center in Peru.Heliyon · 2023Article
- Deficiency in AK9 causes asthenozoospermia and male infertility by destabilising sperm nucleotide homeostasis.EBioMedicine · 2023Article
- Infertility treatment for patients having a microdeletion of azoospermic factor (AZF).Nagoya journal of medical science · 2023Article
- Gene Polymorphism, Microdeletion, and Gene Expression ofReports of biochemistry & molecular biology · 2023Article
- The predictive factors of successful sperm retrieval for men with Y chromosome AZFc microdeletion.Journal of assisted reproduction and genetics · 2022Article
- Application of real-time shear wave elastography in the assessment of male infertility.Quantitative imaging in medicine and surgery · 2022Article
- Unraveling the Molecular Impact of Sperm DNA Damage on Human Reproduction.Advances in experimental medicine and biology · 2022Article
- The effects of Y chromosome microdeletions onTranslational andrology and urology · 2021Review
- Y chromosome microdeletion and cytogenetic findings in male infertility: A cross-sectional descriptive study.International journal of reproductive biomedicine · 2021Article
- Predictors of surgical sperm retrieval in non-obstructive azoospermia: summary of current literature.International urology and nephrology · 2020Review
- A Schematic Overview of the Current Status of Male Infertility Practice.The world journal of men's health · 2020Review
Corrections and comments
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Authors and funding
9 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The aim of the present work was to present the outcomes of the patients with Y-chromosome microdeletions treated by intracytoplasmic sperm injection (ICSI), either using fresh (TESE) or frozen-thawed (TESE-C) testicular sperm and ejaculated sperm (EJAC). The originality of this work resides in the comparisons between the different types of Y-microdeletions (AZFa, AZFb, and AZFc) and treatments, with detailed demographic, stimulation, embryological, clinical, and newborn (NB) outcomes. Of 125 patients with Y-microdeletions, 33 patients presented severe oligozoospermia (18 performed ICSI with ejaculated sperm) and 92 secretory azoospermia (65 went for TESE with 40 having successful sperm retrieval and performed ICSI). There were 51 TESE treatment cycles and 43 TESE-C treatment cycles, with a birth of 19 NB (2 in AZFa/TESE-C, 12 in AZFc/TESE, and 5 in AZFc/TESE-C). Of the 29 EJAC cycles, there was a birth of 8 NB (in AZFc). In TESE and EJAC cycles, there were no significant differences in embryological and clinical parameters. In TESE-C cycles, there was a significant lower oocyte maturity rate, embryo cleavage rate and mean number of embryos transferred in AZFb, and a higher mean number of oocytes and lower fertilization rate in AZFc. In conclusion, although patients with AZFc microdeletions presented a high testicular sperm recovery rate and acceptable clinical outcomes, cases with AZFa and AZFb microdeletions presented a poor prognosis. Due to the reported heredity of microdeletions, patients should be informed about the infertile consequences on NB and the possibility of using preimplantation genetic diagnosis for female sex selection.
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Registered trials
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