ArticleScientific reports2016
Cytotoxic and mutagenic potential of solutions exposed to cold atmospheric plasma.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
45 citing papers in PubMed.
- The activity of cold atmospheric plasma against high-grade glioma: a review.Journal of neuro-oncology · 2025Review
- Inactivation of Emerging Opportunistic Foodborne PathogensFoods (Basel, Switzerland) · 2025Review
- Investigating the effects of microwave plasma on bacterial cell structures, viability, and membrane integrity.Scientific reports · 2025Article
- Article
- Non-thermal plasma as promising anti-cancer therapy against bladder cancer by inducing DNA damage and cell cycle arrest.Scientific reports · 2025Article
- Synergistic Antioxidant Effects of Molecular Hydrogen and Cold Atmospheric Plasma in Enhancing Mesenchymal Stem Cell Therapy.Antioxidants (Basel, Switzerland) · 2024Review
- Cold Atmospheric Plasma Induces Growth Arrest and Apoptosis in Neurofibromatosis Type 1-Associated Peripheral Nerve Sheath Tumor Cells.Biomedicines · 2024Article
- Cold Atmospheric Pressure Plasma-Activated Medium Modulates Cellular Functions of Human Mesenchymal Stem/Stromal Cells In Vitro.International journal of molecular sciences · 2024Article
- Article
- Cold Plasma-Assisted Extraction of Phytochemicals: A Review.Foods (Basel, Switzerland) · 2023Review
- Effects of Plasma-Activated Water Treatment on the Inactivation of Microorganisms Present on Cherry Tomatoes and in Used Wash Solution.Foods (Basel, Switzerland) · 2023Article
- Comparative efficacy evaluation of disinfectants against severe acute respiratory syndrome coronavirus-2.The Journal of hospital infection · 2023Article
- Inhibitory Effects of Cold Atmospheric Plasma on Inflammation and Tumor-Like Feature of Fibroblast-Like Synoviocytes from Patients with Rheumatoid Arthritis.Inflammation · 2022Article
- Efficacy of plasma activated saline in a co-culture infection control model.Scientific reports · 2022Article
- Preclinical Cold Atmospheric Plasma Cancer Treatment.Cancers · 2022Review
- Cold Argon Athmospheric Plasma for Biomedicine: Biological Effects, Applications and Possibilities.Antioxidants (Basel, Switzerland) · 2022Review
- Pyocyanin biosynthesis protects Pseudomonas aeruginosa from nonthermal plasma inactivation.Microbial biotechnology · 2022Article
- Article
- Selective Apoptotic Effect of Plasma Activated Liquids on Human Cancer Cell Lines.Molecules (Basel, Switzerland) · 2021Article
- Cold Atmospheric Pressure Plasma-Activated Medium Induces Selective Cell Death in Human Hepatocellular Carcinoma Cells Independently of Singlet Oxygen, Hydrogen Peroxide, Nitric Oxide and Nitrite/Nitrate.International journal of molecular sciences · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The exposure of aqueous solutions to atmospheric plasmas results in the generation of relatively long-lived secondary products such as hydrogen peroxide which are biologically active and have demonstrated anti-microbial and cytotoxic activity. The use of plasma-activated solutions in applications such as microbial decontamination or anti-cancer treatments requires not only adequate performance on target cells but also a safe operating window regarding the impact on surrounding tissues. Furthermore the generation of plasma-activated fluids needs to be considered as a by-stander effect of subjecting tissue to plasma discharges. Cytotoxicity and mutagenicity assays using mammalian cell lines were used to elucidate the effects of solutions treated with di-electric barrier discharge atmospheric cold plasma. Plasma-treated PBS inhibited cell growth in a treatment time-dependent manner showing a linear correlation to the solutions' peroxide concentration which remained stable over several weeks. Plasma-treated foetal bovine serum (FBS) acting as a model for complex bio-fluids showed not only cytotoxic effects but also exhibited increased mutagenic potential as determined using the mammalian HPRT assay. Further studies are warranted to determine the nature, causes and effects of the cyto- and genotoxic potential of solutions exposed to plasma discharges to ensure long-term safety of novel plasma applications in medicine and healthcare.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.