ArticlePLoS genetics2016
An Energy-Independent Pro-longevity Function of Triacylglycerol in Yeast.
Article in PLoS genetics, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
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Who cites it
26 citing papers in PubMed, 52 citations in OpenAlex.
- Submicron infrared spectroscopy assessment of single-cell phenotypic diversity in microbial lipid production.Microbial cell factories · 2025Article
- General autophagy-dependent and -independent lipophagic processes collaborate to regulate the overall level of lipophagy in yeast.Autophagy · 2024Article
- Relationship between Life's Essential 8 and metabolic syndrome among older Americans (NHANES, 2007-2010): navigating biological aging and inflammation.Frontiers in medicine · 2024Article
- The endoribonuclease Arlr is required to maintain lipid homeostasis by downregulating lipolytic genes during aging.Nature communications · 2023Article
- The lipidomes ofAging · 2023Article
- The Lipid Profile of theJournal of fungi (Basel, Switzerland) · 2022Article
- Phage defence by deaminase-mediated depletion of deoxynucleotides in bacteria.Nature microbiology · 2022Article
- Article
- UHPLC-HRMS-Based Untargeted Lipidomics Reveal Mechanism of Antifungal Activity of Carvacrol againstFoods (Basel, Switzerland) · 2021Article
- The Role of Sch9 and the V-ATPase in the Adaptation Response to Acetic Acid and the Consequences for Growth and Chronological Lifespan.Microorganisms · 2021Article
- Lipid metabolism and lipid signals in aging and longevity.Developmental cell · 2021Review
- Lipid Droplets Protect Aging Mitochondria and Thus Promote Lifespan in Yeast Cells.Frontiers in cell and developmental biology · 2021Article
- Targeting metabolic pathways for extension of lifespan and healthspan across multiple species.Ageing research reviews · 2020Review
- Article
- Intragenic repeat expansion in the cell wall protein geneGenome research · 2020Article
- Cell organelles and yeast longevity: an intertwined regulation.Current genetics · 2020Review
- Advances in understanding mechanisms of long-term sperm storage-the soft-shelled turtle model.Histology and histopathology · 2020Article
- Drosophila Snazarus Regulates a Lipid Droplet Population at Plasma Membrane-Droplet Contacts in Adipocytes.Developmental cell · 2019Article
- The Dual Role of the Pervasive "Fattish" Tissue Remodeling With Age.Frontiers in endocrinology · 2019Review
- Obesity and Aging in theInternational journal of molecular sciences · 2018Review
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Intracellular triacylglycerol (TAG) is a ubiquitous energy storage lipid also involved in lipid homeostasis and signaling. Comparatively, little is known about TAG's role in other cellular functions. Here we show a pro-longevity function of TAG in the budding yeast Saccharomyces cerevisiae. In yeast strains derived from natural and laboratory environments a correlation between high levels of TAG and longer chronological lifespan was observed. Increased TAG abundance through the deletion of TAG lipases prolonged chronological lifespan of laboratory strains, while diminishing TAG biosynthesis shortened lifespan without apparently affecting vegetative growth. TAG-mediated lifespan extension was independent of several other known stress response factors involved in chronological aging. Because both lifespan regulation and TAG metabolism are conserved, this cellular pro-longevity function of TAG may extend to other organisms.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.