ReviewPhysiology & behavior2016
Substance use modulates stress reactivity: Behavioral and physiological outcomes.
Review in Physiology & behavior, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 80 citations in OpenAlex.
- Review
- Post-Heroin Post-Traumatic Stress Disorder Spectrum: Heroin Addiction as a Generator of Trauma Sensitisation in Everyday Life: A Perspective Review.Journal of clinical medicine · 2025Article
- Housing insecurity pathways to physiological and epigenetic manifestations of health among aging adults: a conceptual model.Frontiers in public health · 2025Review
- Altered Physiological, Affective, and Functional Connectivity Responses to Acute Stress in Patients With Alcohol Use Disorder.Biological psychiatry global open science · 2024Article
- Hair cortisol levels are associated with overweight and obesity in the ELSA-Brasil cohort.Frontiers in endocrinology · 2024Article
- Characteristics of Stress Sensitivity in Heroin Use Disorder Patients during Their Opioid Agonist Treatment.International journal of environmental research and public health · 2023Article
- Qualitative exploration of the early experiences of opioid use disorder patients from private clinics after Russia's invasion of Ukraine in five major cities in Ukraine.Frontiers in public health · 2023Article
- Integrated Supports for Women and Girls Experiencing Substance Use and Complex Needs.Substance abuse : research and treatment · 2023Article
- [Depression, anxiety and stress in college students before and during the first three months of COVID-19 lockdown].Revista colombiana de psiquiatria · 2022Article
- Perceived stigma, substance use and self-medication in night-shift healthcare workers: a qualitative study.BMC health services research · 2022Article
- Prenatal cigarette smoking as a mediator between racism and depressive symptoms: The Biosocial Impact on Black Births Study.Public health nursing (Boston, Mass.) · 2020Article
- Is the Urine Cannabinoid Level Measured via a Commercial Point-of-Care Semiquantitative Immunoassay a Cannabis Withdrawal Syndrome Severity Predictor?Frontiers in psychiatry · 2020Article
- High Frequency of Bipolar Disorder Comorbidity in Medical Inpatients.Iranian journal of psychiatry · 2019Article
- Exacerbated Craving in the Presence of Stress and Drug Cues in Drug-Dependent Patients.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2018Observational
- Nicotinic Cholinergic System in the Hypothalamus Modulates the Activity of the Hypothalamic Neuropeptides During the Stress Response.Current neuropharmacology · 2018Review
- Neural responses to negative outcomes predict success in community-based substance use treatment.Addiction (Abingdon, England) · 2017Article
- The cannabis withdrawal syndrome: current insights.Substance abuse and rehabilitation · 2017Review
- Editorial introduction: The effects of somatic disease and environmental insults on the stress response.Physiology & behavior · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
Drug addiction is a major public health concern in the United States costing taxpayers billions in health care costs, lost productivity and law enforcement. However, the availability of effective treatment options remains limited. The development of novel therapeutics will not be possible without a better understanding of the addicted brain. Studies in both clinical and preclinical models indicate that chronic drug use leads to alterations in the body and brain's response to stress. Dysregulation of the hypothalamic-pituitary-adrenal (HPA) axis may shed light on the ability of stress to increase vulnerability to relapse. Further, within both the HPA axis and limbic brain regions, corticotropin-releasing factor (CRF) is critically involved in the brain's response to stress. Alterations in both central and peripheral CRF activity seen following chronic drug use provide a mechanism by which substance use can alter stress reactivity, thus mediating addictive phenotypes. While many reviews have focused on how stress alters drug-mediated changes in physiology and behavior, the goal of this review is to focus on how substance use alters responses to stress.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.