Evidence map›Paper›PMID 26907705›Full record

ArticleScientific reports2016

TLR5 mediates CD172α(+) intestinal lamina propria dendritic cell induction of Th17 cells.

Han Liu, Feidi Chen, Wei Wu, Anthony T Cao, Xiaochang Xue, Suxia Yao, Heather L Evans-Marin, Yan-Qing Li, Yingzi Cong

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
2.8field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 40 citations in OpenAlex.

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  14. Ingested ACTH blocks Th17 production by inhibiting GALT IL-6.Journal of the neurological sciences · 2020
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 2 countries.

Han LiuDepartment of Gastroenterology, The Qilu Hospital, Shandong University, Shandong, China.
Feidi ChenDepartment of Pathology, University of Texas Medical Branch, USA.
Wei WuDepartment of Microbiology and Immunology, and University of Texas Medical Branch, USA.
Anthony T CaoDepartment of Microbiology and Immunology, and University of Texas Medical Branch, USA.
Xiaochang XueDepartment of Microbiology and Immunology, and University of Texas Medical Branch, USA.
Suxia YaoDepartment of Microbiology and Immunology, and University of Texas Medical Branch, USA.
Heather L Evans-MarinDepartment of Microbiology and Immunology, and University of Texas Medical Branch, USA.
Yan-Qing LiDepartment of Gastroenterology, The Qilu Hospital, Shandong University, Shandong, China.
Yingzi CongDepartment of Microbiology and Immunology, and University of Texas Medical Branch, USA.
The University of Texas Medical Branch at Galveston · USQilu Hospital of Shandong University · CN

Funding

Th17-IgA Axis in Regulation of Intestinal InflammationR01DK105585 · NIDDK · UNIVERSITY OF TEXAS MED BR GALVESTON · PI CONG, YINGZI · 2016 to 2020
$1.8M
microRNA-10a Regulation of Inflammatory Bowel DiseasesR01DK098370 · NIDDK · UNIVERSITY OF TEXAS MED BR GALVESTON · PI CONG, YINGZI · 2013 to 2016
$1.3M
NIDDK NIH HHS DK098370NIDDK NIH HHS DK105585NIDDK NIH HHS R01 DK098370NIDDK NIH HHS R01 DK105585
6 · The paper itself

Abstract

Multiple mechanisms exist in regulation of host responses to massive challenges from microbiota to maintain immune homeostasis in the intestines. Among these is the enriched Th17 cells in the intestines, which regulates intestinal homeostasis through induction of antimicrobial peptides and secretory IgA among others. However, the means by which Th17 cells develop in response to microbiota is still not completely understood. Although both TLR5 and CD172α(+) lamina propria dendritic cells (LPDC) have been shown to promote Th17 cell development, it is still unclear whether TLR5 mediates the CD172α(+)LPDC induction of Th17 cells. By using a microbiota antigen-specific T cell reporter mouse system, we demonstrated that microbiota antigen-specific T cells developed into Th17 cells in the intestinal LP, but not in the spleen when transferred into TCRβxδ(-/-) mice. LPDCs expressed high levels of TLR5, and most CD172α(+)LPDCs also co-expressed TLR5. LPDCs produced high levels of IL-23, IL-6 and TGFβ when stimulated with commensal flagellin and promoted Th17 cell development when cultured with full-length CBir1 flagellin but not CBir1 peptide. Wild-type CD172α(+), but not CD172α(-), LPDCs induced Th17 cells, whereas TLR5-deficient LPDC did not induce Th17 cells. Our data thereby demonstrated that TLR5 mediates CD172α(+)LPDC induction of Th17 cells in the intestines.

Indexed as

Immunity, MucosalAnimalsDendritic CellsFlagellinGene Expression RegulationHomeostasisInterleukin-23Interleukin-6Intestinal MucosaMiceMice, Inbred C57BLMice, KnockoutPrimary Cell CultureReceptors, Antigen, T-Cell, alpha-betaReceptors, Antigen, T-Cell, gamma-deltaReceptors, ImmunologicCBir1 flagellinFlagellinInterleukin-23Interleukin-6Receptors, Antigen, T-Cell, alpha-betaReceptors, Antigen, T-Cell, gamma-deltaReceptors, ImmunologicSirpa protein, mouseToll-Like Receptor 5Transforming Growth Factor beta

Identifiers

PMID26907705
PMCPMC4764953
OpenAlexW2401206045

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.