Evidence map›Paper›PMID 26907689›Full record

ReviewThe Journal of biological chemistry2016

Heterotrimeric G Protein-coupled Receptor Signaling in Yeast Mating Pheromone Response.

Christopher G Alvaro, Jeremy Thorner

Abstract readReview
In one paragraph

Review in The Journal of biological chemistry, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 70 papers.

0numbers the graph read from it
0cells of the map it votes in
70citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

70 citing papers in PubMed.

  1. Regulation of Translation by PKA Signaling Pathway.International journal of molecular sciences · 2026
    Review
  2. The Origins of GPCRs.International journal of molecular sciences · 2026
    Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Role of Gα-MAPK interaction in mating ofMolecular biology of the cell · 2025
    Article
  10. Article
  11. Review
  12. Article
  13. Review
  14. Article
  15. Article
  16. Article
  17. Review
  18. Article
  19. Article
  20. A peroxidase-derived ligand that inducesFrontiers in cellular and infection microbiology · 2023
    Article

10 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Christopher G AlvaroFrom the Division of Biochemistry, Biophysics and Structural Biology, Department of Molecular and Cell Biology, University of California, Berkeley, California 94720-3202.
Jeremy ThornerFrom the Division of Biochemistry, Biophysics and Structural Biology, Department of Molecular and Cell Biology, University of California, Berkeley, California 94720-3202 jthorner@berkeley.edu.

Funding

THE MOLECULAR BASIS OF CELL FUNCTIONT32GM007232 · NIGMS · UNIVERSITY OF CALIFORNIA BERKELEY · PI BILDER, DAVID, UNAL, ELCIN · 1985 to 2022
$36.4M
Yeast Protein Kinase Signaling Networks: Specificity, Regulation and FunctionR01GM021841 · NIGMS · UNIVERSITY OF CALIFORNIA BERKELEY · PI THORNER, JEREMY W. · 1985 to 2019
$11.8M
YEAST PEPTIDE HORMONE SYNTHESIS AND SIGNAL TRANSDUCTIONR37GM021841 · NIGMS · UNIVERSITY OF CALIFORNIA BERKELEY · PI THORNER, JEREMY W. · 1989 to 1998
–
NIGMS NIH HHS GM07232NIGMS NIH HHS GM21841NIGMS NIH HHS R01 GM021841NIGMS NIH HHS T32 GM007232
6 · The paper itself

Abstract

The DNAs encoding the receptors that respond to the peptide mating pheromones of the budding yeastSaccharomyces cerevisiaewere isolated in 1985, and were the very first genes for agonist-binding heterotrimeric G protein-coupled receptors (GPCRs) to be cloned in any organism. Now, over 30 years later, this yeast and its receptors continue to provide a pathfinding experimental paradigm for investigating GPCR-initiated signaling and its regulation, as described in this retrospective overview.

Indexed as

Signal TransductionDNA, FungalGene Expression Regulation, FungalHeterotrimeric GTP-Binding ProteinsMAP Kinase Signaling SystemPheromonesReceptors, G-Protein-CoupledReceptors, PheromoneSaccharomyces cerevisiaeSaccharomyces cerevisiae ProteinsDNA, FungalHeterotrimeric GTP-Binding ProteinsPheromonesReceptors, G-Protein-CoupledReceptors, PheromoneSaccharomyces cerevisiae Proteinsadaptor proteincell adhesioncell cycle arrestcell differentiationcell fusiongene regulationG proteinG protein-coupled receptor (GPCR)mitogen-activated protein kinase (MAPK)morphogenesisnuclear fusionpolarized morphogenesispost-translational modification (PTM)protein phosphorylationSaccharomyces cerevisiaescaffold proteinsignal transduction

Identifiers

PMID26907689
PMCPMC4824985

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.