Evidence map›Paper›PMID 26907564›Full record

ArticleJournal of geriatric oncology2016

Association of falls with health-related quality of life (HRQOL) in older cancer survivors: A population based study.

Chintan Pandya, Allison Magnuson, William Dale, Lisa Lowenstein, Chunkit Fung, Supriya G Mohile

Registry-linked trialOpen access · greenAbstract read
In one paragraph

Article in Journal of geriatric oncology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07044427 (Investigation of Fall Risk Factors and Implementation of an Exercise Intervention for Prevention of Falls in Patients With Multiple Myeloma), which is not on this map. Cited by 23 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed, 2 pooled it
10.2field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07044427 narecruitingnot on this mapstarted 2024, after this paper: background citation

Investigation of Fall Risk Factors and Implementation of an Exercise Intervention for Prevention of Falls in Patients With Multiple Myeloma

TypeinterventionalSponsorUniversity Hospital HeidelbergRan2024 to 2026Enrolled60ConditionsMultiple Myeloma, Fall Risk Factors, Strength Training Effects, Balance Training EffectsArmsStrength and balance training in combination with a treadmill-based pertubation intervention
3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 2 syntheses or guidelines pooled it, 46 citations in OpenAlex.

  1. Pooled it
  2. Falls in older adults with cancer: an updated systematic review of prevalence, injurious falls, and impact on cancer treatment.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2021
    Pooled it
  3. Incidence and associated factors of falls in patients with chemotherapy-induced peripheral neuropathy: a scoping review and evidence mapping.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026
    Article
  4. Article
  5. Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Falls, walking or balance problems, and limitations in activities of daily living (ADLs) among older endometrial cancer survivors.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2022
    Article
  11. Article
  12. Article
  13. Physical function measurement in older long-term cancer survivors.Journal of frailty, sarcopenia and falls · 2021
    Article
  14. Article
  15. Association between cardiorespiratory fitness, obesity, and incidence of atrial fibrillation.International journal of cardiology. Heart & vasculature · 2020
    Article
  16. Article
  17. Health-related quality of life and oncologic outcomes after surgery in older adults with colorectal cancer.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2020
    Article
  18. Health status of older cancer survivors-results of the PolSenior study.Journal of cancer survivorship : research and practice · 2018
    Article
  19. Falls in older adults with multiple myeloma.European journal of haematology · 2018
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Chintan PandyaDivision of Health Policy and Outcomes Research, Department of Public Health Sciences, University of Rochester Medical Center, Rochester, NY, USA.
Allison MagnusonDivision of Medical Oncology, James Wilmot Cancer Center, University of Rochester Medical Center, Rochester, NY, USA.
William DaleDivision of Geriatrics and Palliative Care, University of Chicago, Chicago, IL, USA.
Lisa LowensteinDivision of Medical Oncology, James Wilmot Cancer Center, University of Rochester Medical Center, Rochester, NY, USA.
Chunkit FungDivision of Medical Oncology, James Wilmot Cancer Center, University of Rochester Medical Center, Rochester, NY, USA.
Supriya G MohileDivision of Medical Oncology, James Wilmot Cancer Center, University of Rochester Medical Center, Rochester, NY, USA. Electronic address: supriya_mohile@urmc.rochester.edu.
University of Rochester Medical Center · USUniversity of Chicago · US

Funding

URCC NCORP Research BaseUG1CA189961 · NCI · UNIVERSITY OF ROCHESTER · PI Michelle C Janelsins, KAREN M. MUSTIAN · 2014 to 2026
$67.7M
Cancer Control Research Training Curriculum (R25T)R25CA102618 · NCI · UNIVERSITY OF ROCHESTER · PI JANELSINS, MICHELLE C, MORROW, GARY R · 2004 to 2018
$6.7M
Geriatric Assessment - Driven Interventions for Older Cancer PatientsR03AG042342 · NIA · UNIVERSITY OF ROCHESTER · PI MOHILE, SUPRIYA G. · 2012 to 2013
$167k
NCI NIH HHS R25 CA102618NCI NIH HHS UG1 CA189961NIA NIH HHS R03 AG042342
6 · The paper itself

Abstract

objectiveTo examine the association between falls and health-related quality of life (HRQOL) in older cancer survivors. MATERIALS AND

methodsUsing the 2006-2011 Surveillance, Epidemiology, and End Results cancer registry system and the Medicare Health Outcomes Survey (SEER-MHOS) linkage database, a cross-sectional analysis was performed including 17,958 older cancer survivors. Multivariable regression models were used to evaluate the association of falls with HRQOL measured by the physical component summary (PCS) and mental component summary (MCS) scores on the Veteran RAND 12-item health survey after controlling for demographic, health- and cancer-related factors. A longitudinal analysis using the analysis of covariance (ANCOVA) models was also conducted comparing changes in HRQOL of older cancer survivors who fell with HRQOL of older patients with cancer who did not fall.

resultsIn the cross-sectional analysis, 4524 (25%) cancer survivors who fell reported a significantly lower PCS (-2.18; SE=0.16) and MCS (2.00; SE=0.17) scores compared to those who did not (N=13,434). In the longitudinal analysis, after adjusting for baseline HRQOL scores and covariates, patients who fell reported a decline in mean HRQOL scores of both PCS (-1.54; SE=0.26) and MCS (-1.71; SE=0.27). Presence of depression, functional impairment and comorbidities was significantly associated with lower HRQOL scores.

conclusionFalls are associated with lower HRQOL scores and are associated with a significant prospective decline in HRQOL in older cancer survivors. Further research is necessary to determine if assessment and intervention programs can help improve HRQOL by reducing the likelihood of falls.

Indexed as

Activities of Daily LivingHealth StatusNeoplasmsQuality of LifeAccidental FallsAgedAged, 80 and overCancer SurvivorsComorbidityCross-Sectional StudiesDatabases, FactualFemaleHumansLongitudinal StudiesMaleMedicareCancer survivorsElderly AmericansFallsHealth-related quality of lifePatient reported outcomes

Identifiers

PMID26907564
PMCPMC4871754
OpenAlexW2282691946

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.