Evidence map›Paper›PMID 26907563›Full record

ArticleJournal of geriatric oncology2016

Patient-reported versus objectively-measured physical function and mortality risk among cancer survivors.

Justin C Brown, Michael O Harhay, Meera N Harhay

Abstract readComparative Study
In one paragraph

Article in Journal of geriatric oncology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Trial
  3. Trial
  4. Trial
  5. Article
  6. Article
  7. Article
  8. Review
  9. Article
  10. Mobility Assessment Instruments.Seminars in oncology nursing · 2024
    Review
  11. Article
  12. Article
  13. Falls, walking or balance problems, and limitations in activities of daily living (ADLs) among older endometrial cancer survivors.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2022
    Article
  14. Article
  15. Physical function measurement in older long-term cancer survivors.Journal of frailty, sarcopenia and falls · 2021
    Article
  16. Function-related Indicators and Outcomes of Screening Mammography in Older Women: Evidence from the Breast Cancer Surveillance Consortium Cohort.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2021
    Article
  17. Ambulatory Function and Mortality among Cancer Survivors in the NIH-AARP Diet and Health Study.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2021
    Article
  18. Development and Validation of a Risk Tool for Predicting Severe Toxicity in Older Adults Receiving Chemotherapy for Early-Stage Breast Cancer.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2021
    Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Justin C BrownCenter for Clinical Epidemiology & Biostatistics, University of Pennsylvania, USA.
Michael O HarhayCenter for Clinical Epidemiology & Biostatistics, University of Pennsylvania, USA.
Meera N HarhayDivision of Nephrology, Department of Medicine, Drexel University College of Medicine, USA.

Funding

The Women In Steady Exercise Research (WISER) SurwVor TrialU54CA155850 · NCI · UNIVERSITY OF PENNSYLVANIA · PI SCHMITZ, KATHRYN H. · 2011 to 2015
$9.1M
Patterns and Implications of Functional Decline Among Kidney Transplant CandidatesK23DK105207 · NIDDK · DREXEL UNIVERSITY · PI HARHAY, MEERA NAIR · 2015 to 2019
$861k
The COURAGE Trial: Colon Recurrence and Aerobic Exercise: A Feasibility StudyR21CA182767 · NCI · UNIVERSITY OF PENNSYLVANIA · PI SCHMITZ, KATHRYN H. · 2014 to 2015
$377k
Rehospitalization after Renal Transplant: Patterns, Predictors, & ImplicationsF32DK096758 · NIDDK · UNIVERSITY OF PENNSYLVANIA · PI HARHAY, MEERA NAIR · 2013 to 2013
$73k
Methods to improve the detection of treatment effects in ARDS clinical trialsF31HL127947 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI HARHAY, MICHAEL OSCAR · 2015 to 2016
$71k
Effects of Exercise on Visceral Adiposity & Hyperinsulinemia in Colon Cancer SurvivorF31CA192560 · NCI · UNIVERSITY OF PENNSYLVANIA · PI BROWN, JUSTIN C · 2015 to 2016
$69k
NCI NIH HHS F31 CA192560NCI NIH HHS F31-CA192560NCI NIH HHS R21-CA182726NCI NIH HHS R21 CA182767NCI NIH HHS U54 CA155850NHLBI NIH HHS F31 HL127947NHLBI NIH HHS F31-HL127947NIDDK NIH HHS F32 DK096758NIDDK NIH HHS F32-DK096758NIDDK NIH HHS K23 DK105207
6 · The paper itself

Abstract

objectiveThis study aimed to characterize the relationship of patient-reported functional limitations, gait speed, and mortality risk among cancer survivors. MATERIALS AND

methodsThis study included cancer survivors from the Third National Health and Nutrition Survey. Patient-reported functional limitations were quantified by asking participants to assess their ability to complete five tasks: (1) walking 1/4 mi, (2) walking up 10 steps, (3) stooping, crouching, or kneeling, (4) lifting or carrying an object of 10 lb, and (5) standing up from an armless chair. Gait speed was quantified using a 2.4-meter walk. Vital status was obtained through the United States National Center for Health Statistics.

resultsThe study sample included 428 cancer survivors who averaged 72.1 years of age. The average number of patient-reported functional limitations was 1.8 (out of 5) and 66% of participants reported ≥1 functional limitation. Patient-reported functional limitations and gait speed were related, such that each functional limitation associated with a -0.08m/s slower gait speed (95% confidence interval: -0.10 to -0.06; P<0.001). During a median follow-up of 11years, 329 (77%) participants died. In multivariable-adjusted analysis, patient-reported functional limitations and survival were related, such that each additional reported functional limitation was associated with a 19% increase in the risk of death (95% confidence interval: 9% to 29%; P<0.001).

conclusionPatient-reported functional limitations are prevalent among cancer survivors, and associate with slower gait speeds and shorter survival. These data may provide increased insight on long-term prognosis and inform clinical decision-making by identifying subgroups of cancer survivors who may benefit from rehabilitative intervention.

Indexed as

Activities of Daily LivingMobility LimitationNeoplasmsSelf ReportSurvivorsAgedAged, 80 and overAttitude to HealthComorbidityFemaleGeriatric AssessmentHealth SurveysHumansMaleMotor SkillsAgingDisabilityExerciseOncologyPhysical activityPhysical function

Identifiers

PMID26907563
PMCPMC4818688

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.