Evidence map›Paper›PMID 26907530›Full record

ReviewAnnual review of pathology2016

Mechanisms of Disease: Pemphigus and Bullous Pemphigoid.

Christoph M Hammers, John R Stanley

Registry-linked trialOpen access · bronzeAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Annual review of pathology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06863454 (Trichoscopy as a Monitoring Tool for Activity and Remission in Pemphigus Vulgaris), which is not on this map. Cited by 161 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
161citing papers in PubMed, 7 pooled it
21.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06863454 not yet recruitingnot on this mapstarted 2025, after this paper: background citation

Trichoscopy as a Monitoring Tool for Activity and Remission in Pemphigus Vulgaris: A Clinical Study Supported by Immunological Evaluation.

TypeobservationalSponsorAssiut UniversityRan2025 to 2026Enrolled62ConditionsPemphigus Vulgaris (PV)ArmsTrichoscopy
3 · Its place in the literature

Who cites it

161 citing papers in PubMed, 7 syntheses or guidelines pooled it, 326 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. A Systematic Review of Drug-Induced Pemphigoid.Acta dermato-venereologica · 2020
    Pooled it
  6. Pooled it
  7. Pooled it
  8. Trial
  9. Article
  10. Review
  11. Review
  12. Article
  13. Review
  14. A diffuse presentation of urticarial bullous pemphigoid.Journal of osteopathic medicine · 2026
    Article
  15. Review
  16. Review
  17. Review
  18. Article
  19. Article
  20. Review

101 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 2 countries.

Christoph M HammersDepartment of Dermatology, University of Pennsylvania, Philadelphia, Pennsylvania 19104; email: jrstan@mail.med.upenn.edu.
John R StanleyDepartment of Dermatology, University of Pennsylvania, Philadelphia, Pennsylvania 19104; email: jrstan@mail.med.upenn.edu.
University of Pennsylvania · US

Funding

Cloning and genetics of human pemphigus autoantibodiesR01AR052672 · NIAMS · UNIVERSITY OF PENNSYLVANIA · PI STANLEY, JOHN R · 2006 to 2015
$3.7M
Understanding molecular mechanisms underlying the formation of the blue nevus andP30AR057217 · NIAMS · UNIVERSITY OF PENNSYLVANIA · PI STANLEY, JOHN R · 2009 to 2013
$3.2M
NIAMS NIH HHS P30 AR057217NIAMS NIH HHS R01 AR052672
6 · The paper itself

Abstract

Pemphigus and bullous pemphigoid are autoantibody-mediated blistering skin diseases. In pemphigus, keratinocytes in epidermis and mucous membranes lose cell-cell adhesion, and in pemphigoid, the basal keratinocytes lose adhesion to the basement membrane. Pemphigus lesions are mediated directly by the autoantibodies, whereas the autoantibodies in pemphigoid fix complement and mediate inflammation. In both diseases, the autoantigens have been cloned and characterized; pemphigus antigens are desmogleins (cell adhesion molecules in desmosomes), and pemphigoid antigens are found in hemidesmosomes (which mediate adhesion to the basement membrane). This knowledge has enabled diagnostic testing for these diseases by enzyme-linked immunosorbent assays and dissection of various pathophysiological mechanisms, including direct inhibition of cell adhesion, antibody-induced internalization of antigen, and cell signaling. Understanding these mechanisms of disease has led to rational targeted therapeutic strategies.

Indexed as

AnimalsHumansPemphigoid, BullousPemphigusautoantibodyautoimmuneblisteringskin

Identifiers

PMID26907530
PMCPMC5560122
OpenAlexW1907326545

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.