ArticleInternational journal of molecular sciences2016
Exploring the Role of Different Neonatal Nutrition Regimens during the First Week of Life by Urinary GC-MS Metabolomics.
Article in International journal of molecular sciences, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 43 citations in OpenAlex.
- Infants Fed Breastmilk or 2'-FL Supplemented Formula Have Similar Systemic Levels of Microbiota-Derived Secondary Bile Acids.Nutrients · 2023Trial
- Sardinian Infants of Diabetic Mothers: A Metabolomics Observational Study.International journal of molecular sciences · 2023Observational
- Urine Metabolomic Profile of Breast- versus Formula-Fed Neonates Using a Synbiotic-Enriched Formula.International journal of molecular sciences · 2022Article
- Metabolic impact of infant formulas in young infants. An outlook from the urine metabolome.Heliyon · 2022Article
- A Comparison of Mother's Milk and the Neonatal Urine Metabolome: A Unique Fingerprinting for Different Nutritional Phenotypes.Metabolites · 2022Article
- A hierarchical Bayesian approach for detecting global microbiome associations.Statistical applications in genetics and molecular biology · 2021Article
- Epigenetics and Modulations of Early Flavor Experiences: Can Metabolomics Contribute to Prevention during Weaning?Nutrients · 2021Review
- Comparative Lipidomic Study of Human Milk from Different Lactation Stages and Milk Formulas.Nutrients · 2020Article
- Article
- Metabolic changes in early neonatal life: NMR analysis of the neonatal metabolic profile to monitor postnatal metabolic adaptations.Metabolomics : Official journal of the Metabolomic Society · 2020Article
- How could metabolomics change pediatric health?Italian journal of pediatrics · 2020Review
- Analysis of Amino Acid Patterns With Nutrition Regimens in Preterm Infants With Extrauterine Growth Retardation.Frontiers in pediatrics · 2020Article
- Advantages and Limitations of the Neonatal Immune System.Frontiers in pediatrics · 2020Review
- DNA Methylation Signatures of Breastfeeding in Buccal Cells Collected in Mid-Childhood.Nutrients · 2019Article
- Metabolomic Insights into the Effects of Breast Milk Versus Formula Milk Feeding in Infants.Current nutrition reports · 2019Review
- [Application of metabolomics in neonatal clinical practice].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2019Review
- Metabolic phenotyping of malnutrition during the first 1000 days of life.European journal of nutrition · 2019Review
- Metabolic Biomarkers of Monochorionic Twins Complicated With Selective Intrauterine Growth Restriction in Cord Plasma and Placental Tissue.Scientific reports · 2018Article
- Human Breast Milk: Exploring the Linking Ring Among Emerging Components.Frontiers in pediatrics · 2018Review
- Review
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In this study, a gas-chromatography mass spectrometry (GC-MS) metabolomics study was applied to examine urine metabolite profiles of different classes of neonates under different nutrition regimens. The study population included 35 neonates, exclusively either breastfed or formula milk fed, in a seven-day timeframe. Urine samples were collected from intrauterine growth restriction (IUGR), large for gestational age (LGA), and appropriate gestational age (AGA) neonates. At birth, IUGR and LGA neonates showed similarities in their urine metabolite profiles that differed from AGA. When neonates started milk feeding, their metabolite excretion profile was strongly characterized by the different diet regimens. After three days of formula milk nutrition, urine had higher levels of glucose, galactose, glycine and myo-inositol, while up-regulated aconitic acid, aminomalonic acid and adipic acid were found in breast milk fed neonates. At seven days, neonates fed with formula milk shared higher levels of pseudouridine with IUGR and LGA at birth. Breastfed neonates shared up-regulated pyroglutamic acid, citric acid, and homoserine, with AGA at birth. The role of most important metabolites is herein discussed.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.