ArticleScientific reports2016
A Novel Method to Simulate the Progression of Collagen Degeneration of Cartilage in the Knee: Data from the Osteoarthritis Initiative.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.
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Who cites it
46 citing papers in PubMed, 113 citations in OpenAlex.
- Longitudinal analysis of tibiofemoral cartilage contact area and position in ACL reconstructed patients.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2018Trial
- Estimation of the Effect of Body Weight on the Development of Osteoarthritis Based on Cumulative Stresses in Cartilage: Data from the Osteoarthritis Initiative.Annals of biomedical engineering · 2018Trial
- From Joint Loading to Osteoarthritis: A Multiscale Review of Knee Mechanobiology and Digital Modelling.International journal of molecular sciences · 2026Review
- A novel integrative multi-scale framework of inflammation and mechanical loading in knee osteoarthritis.Biomechanics and modeling in mechanobiology · 2026Article
- MMP release following cartilage injury leads to collagen loss in intact tissue: A computational study.PLoS computational biology · 2026Article
- Next-generation osteoarthritis models: integrating biological, computational, and engineering approaches.Stem cell research & therapy · 2025Review
- Does Valgus Bracing Reduce Estimates of Medial Tibial, Medial Femoral, and Patella Cartilage Contact Pressure in Varus Malaligned Medial Knee Osteoarthritis?Clinical orthopaedics and related research · 2025Article
- Bayesian Graphical Models for Multiscale Inference in Medical Image-Based Joint Degeneration Analysis.Diagnostics (Basel, Switzerland) · 2025Review
- Reduced Muscle Strength Can Alter the Impact of Gait Modifications on Knee Cartilage Mechanics.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2025Article
- Biomechanical effects of medial osteoarthritis progression and UKA on knee lateral compartment using fibril-reinforced biphasic material in finite element study.Scientific reports · 2025Article
- Unraveling Osteoarthritis: Mechanistic Insights and Emerging Therapies Targeting Pain and Inflammation.Biomolecules · 2025Review
- Burden of knee osteoarthritis in China and globally from 1992 to 2021, and projections to 2030: a systematic analysis from the Global Burden of Disease Study 2021.Frontiers in public health · 2025Article
- Efficient development of subject-specific finite element knee models: Automated identification of soft-tissue attachments.Journal of biomechanics · 2025Article
- Predicting Knee Joint Contact Force Peaks During Gait Using a Video Camera or Wearable Sensors.Annals of biomedical engineering · 2024Article
- Two-Stage Classification of Future Knee Osteoarthritis Severity After 8 Years Using MRI: Data from the Osteoarthritis Initiative.Annals of biomedical engineering · 2024Article
- Weight-Bearing Physical Activity, Lower-Limb Muscle Mass, and Risk of Knee Osteoarthritis.JAMA network open · 2024Article
- Integration of Swin UNETR and statistical shape modeling for a semi-automated segmentation of the knee and biomechanical modeling of articular cartilage.Scientific reports · 2024Article
- Effects of gait modifications on tissue-level knee mechanics in individuals with medial tibiofemoral osteoarthritis: A proof-of-concept study towards personalized interventions.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2024Article
- Validation and evaluation of subject-specific finite element models of the pediatric knee.Scientific reports · 2023Article
- Finite element analysis of a healthy knee joint at deep squatting for the study of tibiofemoral and patellofemoral contact.Journal of orthopaedics · 2023Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
Abstract
We present a novel algorithm combined with computational modeling to simulate the development of knee osteoarthritis. The degeneration algorithm was based on excessive and cumulatively accumulated stresses within knee joint cartilage during physiological gait loading. In the algorithm, the collagen network stiffness of cartilage was reduced iteratively if excessive maximum principal stresses were observed. The developed algorithm was tested and validated against experimental baseline and 4-year follow-up Kellgren-Lawrence grades, indicating different levels of cartilage degeneration at the tibiofemoral contact region. Test groups consisted of normal weight and obese subjects with the same gender and similar age and height without osteoarthritic changes. The algorithm accurately simulated cartilage degeneration as compared to the Kellgren-Lawrence findings in the subject group with excess weight, while the healthy subject group's joint remained intact. Furthermore, the developed algorithm followed the experimentally found trend of cartilage degeneration in the obese group (R(2) = 0.95, p < 0.05; experiments vs. model), in which the rapid degeneration immediately after initiation of osteoarthritis (0-2 years, p < 0.001) was followed by a slow or negligible degeneration (2-4 years, p > 0.05). The proposed algorithm revealed a great potential to objectively simulate the progression of knee osteoarthritis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.