ArticleDevelopmental cell2016
Distinct Activities of Myf5 and MyoD Indicate Separate Roles in Skeletal Muscle Lineage Specification and Differentiation.
Article in Developmental cell, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 72 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
72 citing papers in PubMed, 108 citations in OpenAlex.
- Article
- Integrating and Orchestrating Multiple Components of Skeletal Muscle Injury and Regeneration.American journal of physiology. Cell physiology · 2026Article
- Combined in ovo and post-hatch choline supplementation enhances growth and muscle development in goslings.Poultry science · 2026Article
- Developmental expression of the skeletal muscle determination gene,bioRxiv : the preprint server for biology · 2026Article
- HuR-mediated regulation of mTOR mRNA stability promotes the commitment of satellite cells towards myogenesis.Cell death & disease · 2026Article
- Article
- Reconstructing epigenomic dynamics through a single-cell multi-epigenome data integration framework.Nature communications · 2025Article
- Identification and characterization of GHR gene promoter of yak.Scientific reports · 2025Article
- miR-125b Orchestrates the Proliferation and Fusion of Myoblasts in Chinese Perch by Targeting the MyoD and Myomaker.Marine biotechnology (New York, N.Y.) · 2025Article
- Pleiotropy increases with gene age in six model multicellular eukaryotes.Evolution letters · 2025Article
- RelA Inhibits Embryonic Myogenesis by Coordinately Regulating a Novel Distal Enhancer of Myogenin.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- A discrete region of the D4Z4 is sufficient to initiate epigenetic silencing.Human molecular genetics · 2025Article
- Mechanisms driving functional divergence of transcription factor paralogs.The New phytologist · 2025Review
- RNF138 regulates skeletal muscle differentiation via the Wnt/β-catenin signaling pathway.Theranostics · 2025Article
- START domains generate paralog-specific regulons from a single network architecture.Nature communications · 2024Article
- Dual-specificity phosphatases 13 and 27 as key switches in muscle stem cell transition from proliferation to differentiation.Stem cells (Dayton, Ohio) · 2024Article
- Comprehensive analysis of the expression patterns and function of theFrontiers in veterinary science · 2024Article
- Myogenesis gone awry: the role of developmental pathways in rhabdomyosarcoma.Frontiers in cell and developmental biology · 2024Review
- Effect of glucose and lysine supplementation on myogenic and adipogenic gene expression in muscle satellite cells isolated from Hanwoo with different genotypes of PLAG1: Implications for cell-based food production.Current research in food science · 2024Article
- Emerging role of HDAC11 in skeletal muscle biology.Frontiers in cell and developmental biology · 2024Article
12 more citing papers are in PubMed but not listed here.
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Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
Abstract
Most transcription factor families contain highly related paralogs generated by gene duplication, and functional divergence is generally accomplished by activation of distinct sets of genes by each member. Here we compare the molecular functions of Myf5 and MyoD, two highly related bHLH transcription factors that regulate skeletal muscle specification and differentiation. We find that MyoD and Myf5 bind the same sites genome-wide but have distinct functions: Myf5 induces histone acetylation without Pol II recruitment or robust gene activation, whereas MyoD induces histone acetylation, recruits Pol II, and robustly activates gene transcription. Therefore, the initial specification of the muscle lineage by Myf5 occurs without significant induction of gene transcription. Transcription of the skeletal muscle program is then achieved by the subsequent expression of MyoD, which binds to the same sites as Myf5, indicating that each factor regulates distinct steps in gene initiation and transcription at a shared set of binding sites.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.