SynthesisScientific reports2016
Disorganization of white matter architecture in major depressive disorder: a meta-analysis of diffusion tensor imaging with tract-based spatial statistics.
Synthesis in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 71 papers, 8 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
71 citing papers in PubMed, 8 syntheses or guidelines pooled it.
- A working model linking the psychopathology and pathophysiology of major depressive disorder - an umbrella review of neuroimaging studies and a conceptual framework.Molecular psychiatry · 2025Pooled it
- Structural connectivity abnormalities in suicidal thoughts and behaviours: a meta-analysis.Translational psychiatry · 2025Pooled it
- Brain connectivity in major depressive disorder: a precision component of treatment modalities?Translational psychiatry · 2023Pooled it
- Microstructural white matter alterations associated with migraine headaches: a systematic review of diffusion tensor imaging studies.Brain imaging and behavior · 2022Pooled it
- Structural connectivity associated with familial risk for mental illness: A meta-analysis of diffusion tensor imaging studies in relatives of patients with severe mental disorders.Human brain mapping · 2022Pooled it
- A meta-analysis of tract-based spatial statistics studies examining white matter integrity in cocaine use disorder.Addiction biology · 2021Pooled it
- Psychoradiologic abnormalities of white matter in patients with bipolar disorder: diffusion tensor imaging studies using tract-based spatial statisticsJournal of psychiatry & neuroscience : JPN · 2019Pooled it
- Trauma-specific Grey Matter Alterations in PTSD.Scientific reports · 2016Pooled it
- Neuroplastic white matter changes in patients with major depression following lysergic acid diethylamide treatment.Cell reports. Medicine · 2026Trial
- White matter predicts tDCS antidepressant effects in a sham-controlled clinical trial study.European archives of psychiatry and clinical neuroscience · 2023Trial
- Psychological and Sleep Effects of Tryptophan and Magnesium-Enriched Mediterranean Diet in Women with Fibromyalgia.International journal of environmental research and public health · 2020Trial
- Multimodal fusion of structural and functional brain imaging in depression using linked independent component analysis.Human brain mapping · 2020Trial
- Assessment of noninvasive quantification of [European journal of nuclear medicine and molecular imaging · 2026Article
- Divergent Myelination or Divergent Trajectories? Insights from MPF Mapping in Bipolar Disorder and Recurrent Depressive Disorder.Bioengineering (Basel, Switzerland) · 2026Article
- Gray and White matter microstructural alterations in major depressive disorder: a multi-center diffusion imaging study.Translational psychiatry · 2026Article
- White matter microstructure alterations from alcohol use disorder persist into early abstinence.Brain communications · 2026Article
- Age-related auditory nerve deficits propagate central gain throughout the auditory system: Associations with cortical microstructure and speech recognition.Neurobiology of aging · 2026Article
- Neural Correlates of Peripheral Inflammation in Major Depressive Disorder and Their Transcriptomic Architecture, Neurochemical Basis, and Behavioral Relevance.Human brain mapping · 2025Article
- White Matter Integrity in Women with Repetitive Traumatic Brain Injury due to Intimate Partner Violence.Journal of neurotrauma · 2025Article
- Longitudinal associations between white matter integrity, early life adversities, and treatment response following cognitive-behavioral therapy in depression.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2025Article
11 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
White matter (WM) abnormalities have long been suspected in major depressive disorder (MDD). Tract-based spatial statistics (TBSS) studies have detected abnormalities in fractional anisotropy (FA) in MDD, but the available evidence has been inconsistent. We performed a quantitative meta-analysis of TBSS studies contrasting MDD patients with healthy control subjects (HCS). A total of 17 studies with 18 datasets that included 641 MDD patients and 581 HCS were identified. Anisotropic effect size-signed differential mapping (AES-SDM) meta-analysis was performed to assess FA alterations in MDD patients compared to HCS. FA reductions were identified in the genu of the corpus callosum (CC) extending to the body of the CC and left anterior limb of the internal capsule (ALIC) in MDD patients relative to HCS. Descriptive analysis of quartiles, sensitivity analysis and subgroup analysis further confirmed these findings. Meta-regression analysis revealed that individuals with more severe MDD were significantly more likely to have FA reductions in the genu of the CC. This study provides a thorough profile of WM abnormalities in MDD and evidence that interhemispheric connections and frontal-striatal-thalamic pathways are the most convergent circuits affected in MDD.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.