Observational studyThe British journal of general practice : the journal of the Royal College of General Practitioners2016
Kawasaki disease incidence in children and adolescents: an observational study in primary care.
Observational study in The British journal of general practice : the journal of the Royal College of General Practitioners, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 34 citations in OpenAlex.
- Validation of a 2-Gene Blood Test for Kawasaki Disease in Febrile Children.JAMA network open · 2026Article
- Atypical Kawasaki disease with giant coronary artery aneurysms in a 2-month-old boy: a case report.Journal of medical case reports · 2024Article
- A Young Patient With Acute Ostial Right Coronary Artery Aneurysm Presenting As ST Elevation Myocardial Infarction.Cureus · 2024Article
- The incidence of Kawasaki disease using hospital admissions data for England 2006-2021.Rheumatology (Oxford, England) · 2023Article
- Bridging a diagnostic Kawasaki disease classifier from a microarray platform to a qRT-PCR assay.Pediatric research · 2023Article
- The Role of Therapeutic Plasma Exchange (TPE) in Multisystem Inflammatory Syndrome in Children (MIS-C).Children (Basel, Switzerland) · 2021Article
- Polymorphism of Proteasomal Genes Can Be a Risk Factor for Systemic Autoimmune Diseases in Children.Journal of pediatric genetics · 2021Article
- High risk of coronary artery aneurysm in Kawasaki disease.Rheumatology (Oxford, England) · 2021Article
- Tight junction protein ZO-1 in Kawasaki disease.BMC pediatrics · 2021Article
- Incidence Rates of Autoimmune Diseases in European Healthcare Databases: A Contribution of the ADVANCE Project.Drug safety · 2021Article
- Kawasaki Disease in Adulthood.JACC. Case reports · 2021Article
- Lessons of the month: A misunderstood teenager with paediatric inflammatory multisystem syndrome - temporarily associated with SARS-CoV-2 admitted under adult medicine.Clinical medicine (London, England) · 2021Article
- Epidemiology of Kawasaki Disease in Europe.Frontiers in pediatrics · 2021Review
- Intensive care admissions of children with paediatric inflammatory multisystem syndrome temporally associated with SARS-CoV-2 (PIMS-TS) in the UK: a multicentre observational study.The Lancet. Child & adolescent health · 2020Observational
- Lifetime cardiovascular management of patients with previous Kawasaki disease.Heart (British Cardiac Society) · 2020Review
- Bifidobacterium plays a protective role in TNF-α-induced inflammatory response in Caco-2 cell through NF-κB and p38MAPK pathways.Molecular and cellular biochemistry · 2020Article
- Lower CMV and EBV Exposure in Children With Kawasaki Disease Suggests an Under-Challenged Immune System.Frontiers in pediatrics · 2020Article
- Sex Differences in Pediatric Rheumatology.Clinical reviews in allergy & immunology · 2019Review
- Immunoglobulin for Kawasaki disease: a 3-year retrospective audit.BMJ paediatrics open · 2019Article
- The Gut Microbiota-Host Partnership as a Potential Driver of Kawasaki Syndrome.Frontiers in pediatrics · 2019Review
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundKawasaki disease is reported to be increasing in incidence and is the commonest childhood cause of acquired heart disease in the Western world.
aimTo determine the current UK incidence of Kawasaki disease across childhood and adolescence; and investigate trends over time and season. DESIGN AND
settingAn observational, descriptive study in the UK.
methodThe Health Improvement Network (THIN) database of primary healthcare records was searched for codes or text indicating Kawasaki disease. Identified records were compared with a study case definition and a date of onset was assigned to cases. The incidence, age/sex distribution, and trend in seasonal and temporal distribution were estimated (2008-2012).
resultsA total of 110 episodes of Kawasaki disease in 109 children were identified from 3.9 million person-years observation. The incidence of Kawasaki disease was 2.8 per 100 000 person-years (95% confidence interval [CI] = 2.3 to 3.4) when aged <20 years; 9.1 (95% CI = 7.3 to 11.2) aged <5 years, and 3.0 per 100 000 (95% CI = 2.0 to 4.3) across the age groups when possible cases were included. More cases were identified in males (55%) with one-fifth of cases diagnosed after 5 years of age. There was no statistically significant trend in incidence over the study years (P = 0.10 adjusted for sex and month), or between seasons (P = 0.65 adjusted for year and sex).
conclusionAlthough the incidence of Kawasaki disease remains low and has stabilised in the UK, GPs should recognise that the condition occurs throughout childhood and across the seasons.
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