Evidence map›Paper›PMID 26906489›Full record

ArticleCurrent biology : CB2016

Adaptive Evolution: Don't Fix What's Broken.

Gaowen Liu, Giulia Rancati

Abstract readComment
PubMed Publisher
In one paragraph

Article in Current biology : CB, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. On the (un)predictability of a large intragenic fitness landscape.Proceedings of the National Academy of Sciences of the United States of America · 2016
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors.

Gaowen LiuInstitute of Medical Biology (IMB), Agency for Science, Technology and Research (A(∗)STAR), Singapore 138648, Singapore; School of Biological Sciences, Nanyang Technological University, Singapore 637551, Singapore.
Giulia RancatiInstitute of Medical Biology (IMB), Agency for Science, Technology and Research (A(∗)STAR), Singapore 138648, Singapore. Electronic address: giulia.rancati@imb.a-star.edu.sg.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Evolution of budding yeast after the removal of an important component of the polarization machinery, BEM1, followed reproducible evolutionary trajectories governed by epistasis. Interestingly, cells restored polarization not by finding a substitute for Bem1 but by rendering its function dispensable.

Indexed as

Adaptation, BiologicalAdaptor Proteins, Signal TransducingSaccharomyces cerevisiaeAdaptor Proteins, Signal Transducing

Identifiers

PMID26906489

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.