Evidence map›Paper›PMID 26906406›Full record

ArticleMucosal immunology2016

Opioid-induced gut microbial disruption and bile dysregulation leads to gut barrier compromise and sustained systemic inflammation.

S Banerjee, G Sindberg, F Wang, J Meng, U Sharma, L Zhang, P Dauer, C Chen, J Dalluge, T Johnson and 1 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Mucosal immunology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 177 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
177citing papers in PubMed, 4 pooled it
9.2field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

177 citing papers in PubMed, 4 syntheses or guidelines pooled it, 260 citations in OpenAlex.

  1. Pooled it
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  5. Opioid Use and Rate of Nicotine Metabolism Among Pregnant Smokers.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2020
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117 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

S BanerjeeDepartment of Surgery and Pharmacology, Division of Infection, Inflammation and Vascular Biology, University of Minnesota, Minneapolis, Minnesota, USA.
G SindbergDepartment of Veterinary Medicine, University of Minnesota, Minneapolis, Minnesota, USA.
F WangDepartment of Veterinary Medicine, University of Minnesota, Minneapolis, Minnesota, USA.
J MengDepartment of Surgery and Pharmacology, Division of Infection, Inflammation and Vascular Biology, University of Minnesota, Minneapolis, Minnesota, USA.
U SharmaDepartment of Surgery and Pharmacology, Division of Infection, Inflammation and Vascular Biology, University of Minnesota, Minneapolis, Minnesota, USA.
L ZhangDepartment of Pharmacology, University of Minnesota, Minneapolis, Minnesota, USA.
P DauerDepartment of Pharmacology, University of Minnesota, Minneapolis, Minnesota, USA.
C ChenDepartment of Food Science and Nutrition, University of Minnesota, Minneapolis, Minnesota, USA.
J DallugeDepartment of Chemistry, University of Minnesota, Minneapolis, Minnesota, USA.
T JohnsonDepartment of Veterinary Medicine, University of Minnesota, Minneapolis, Minnesota, USA.
S RoyDepartment of Surgery and Pharmacology, Division of Infection, Inflammation and Vascular Biology, University of Minnesota, Minneapolis, Minnesota, USA.
University of Minnesota · US

Funding

Subcellular Targeting/Packaging of Opioids/ReceptorsP50DA011806 · NIDA · UNIVERSITY OF MINNESOTA TWIN CITIES · PI LOH, HORACE · 1998 to 2012
$14.0M
Training in PharmacoNeuroImmune Substance Abuse ResearchT32DA007097 · NIDA · UNIVERSITY OF MINNESOTA TWIN CITIES · PI MOLITOR, THOMAS WILLIAM · 1985 to 2021
$13.1M
Opioid Abuse, opportunistic infection and NeuroAIDSR01DA012104 · NIDA · UNIVERSITY OF MINNESOTA TWIN CITIES · PI ROY, SABITA · 1999 to 2013
$3.7M
Gut microbiota disruption by Morphine and in the context of HIV infection contributes to sustained immune activationR01DA037843 · NIDA · UNIVERSITY OF MINNESOTA · PI JOHNSON, TIMOTHY J, ROY, SABITA · 2014 to 2018
$2.8M
Morphine, HIV proteins, wound healing and InfectionR01DA022935 · NIDA · UNIVERSITY OF MINNESOTA · PI ROY, SABITA · 2007 to 2011
$1.7M
Role of microRNAs in opioid drug abuse induced persistent Inflammation and HIV diR01DA031202 · NIDA · UNIVERSITY OF MINNESOTA · PI RAMAKRISHNAN, SUNDARAM, ROY, SABITA · 2011 to 2015
$1.7M
Mechanism underlying Morphine modulation of gut barrier function in the Context oR01DA034582 · NIDA · UNIVERSITY OF MINNESOTA · PI ROY, SABITA · 2013 to 2017
$1.6M
Opioid Drug abuse in the context of opportunistic infection increases susceptibilK05DA033881 · NIDA · UNIVERSITY OF MINNESOTA · PI ROY, SABITA · 2012 to 2016
$661k
HIV and Morphine Increase Susceptibility to Lung Opportunistic Infections by Modulating TLR2/IL17A Mediated Lung InflammationR21HL125021 · NHLBI · UNIVERSITY OF MINNESOTA · PI BANERJEE, SANTANU · 2015 to 2016
$420k
NHLBI NIH HHS R21 HL125021NIDA NIH HHS K05 DA033881NIDA NIH HHS P50 DA011806NIDA NIH HHS R01 DA012104NIDA NIH HHS R01 DA022935NIDA NIH HHS R01 DA031202NIDA NIH HHS R01 DA034582NIDA NIH HHS R01 DA037843NIDA NIH HHS T32 DA007097
6 · The paper itself

Abstract

Morphine and its pharmacological derivatives are the most prescribed analgesics for moderate to severe pain management. However, chronic use of morphine reduces pathogen clearance and induces bacterial translocation across the gut barrier. The enteric microbiome has been shown to have a critical role in the preservation of the mucosal barrier function and metabolic homeostasis. Here, we show for the first time, using bacterial 16s rDNA sequencing, that chronic morphine treatment significantly alters the gut microbial composition and induces preferential expansion of Gram-positive pathogenic and reduction in bile-deconjugating bacterial strains. A significant reduction in both primary and secondary bile acid levels was seen in the gut, but not in the liver with morphine treatment. Morphine-induced microbial dysbiosis and gut barrier disruption was rescued by transplanting placebo-treated microbiota into morphine-treated animals, indicating that microbiome modulation could be exploited as a therapeutic strategy for patients using morphine for pain management.

Indexed as

DysbiosisAnalgesics, OpioidAnimalsBileBile Acids and SaltsCholesterolFecal Microbiota TransplantationGastrointestinal MicrobiomeImmune SystemImmunity, MucosalInflammationIntestinal MucosaLiverMiceMice, KnockoutMorphineAnalgesics, OpioidBile Acids and SaltsCholesterolMorphineReceptors, Opioid, muToll-Like Receptor 2

Identifiers

PMID26906406
PMCPMC4996771
OpenAlexW2289575399

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.