ArticleScientific reports2016
A label-free and portable graphene FET aptasensor for children blood lead detection.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed.
- A Planar-Gate Graphene Field-Effect Transistor Integrated Portable Platform for Rapid Detection of Colon Cancer-Derived Exosomes.Biosensors · 2025Article
- Graphene-based nanotechnology in the Internet of Things: a mini review.Discover nano · 2024Review
- Advancing biological investigations using portable sensors for detection of sensitive samples.Heliyon · 2023Review
- TBA for Sensing Toxic Cations: A Critical Analysis of Structural and Electrical Properties.International journal of molecular sciences · 2023Article
- Graphene-Based Field-Effect Transistors in Biosensing and Neural Interfacing Applications: Recent Advances and Prospects.Analytical chemistry · 2023Review
- Recent Achievements in Electrochemical and Optical Nucleic Acids Based Detection of Metal Ions.Molecules (Basel, Switzerland) · 2022Review
- Ten Years Progress of Electrical Detection of Heavy Metal Ions (HMIs) Using Various Field-Effect Transistor (FET) Nanosensors: A Review.Biosensors · 2021Review
- Review
- Advances in aptamer screening and aptasensors' detection of heavy metal ions.Journal of nanobiotechnology · 2021Review
- Graphene-Based Environmental Sensors: Electrical and Optical Devices.Molecules (Basel, Switzerland) · 2021Review
- From Small Molecules Toward Whole Cells Detection: Application of Electrochemical Aptasensors in Modern Medical Diagnostics.Sensors (Basel, Switzerland) · 2021Review
- Recent Advances in Nanotechnology-Based Biosensors Development for Detection of Arsenic, Lead, Mercury, and Cadmium.International journal of nanomedicine · 2021Review
- Graphene functionalized field-effect transistors for ultrasensitive detection of Japanese encephalitis and Avian influenza virus.Scientific reports · 2020Article
- Graphene-based biosensors for the detection of prostate cancer protein biomarkers: a review.BMC chemistry · 2019Review
- Chemically Functionalised Graphene FET Biosensor for the Label-free Sensing of Exosomes.Scientific reports · 2019Article
- Reduced Carboxylate Graphene Oxide based Field Effect Transistor as PbMicromachines · 2019Article
- Free radical sensors based on inner-cutting graphene field-effect transistors.Nature communications · 2019Article
- Aptamer based nanobiosensors: Promising healthcare devices.Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society · 2019Review
- Microfluidic-based graphene field effect transistor for femtomolar detection of chlorpyrifos.Scientific reports · 2019Article
- Selective layer-free blood serum ionogram based on ion-specific interactions with a nanotransistor.Nature materials · 2018Article
Corrections and comments
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Authors and funding
12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Lead is a cumulative toxicant, which can induce severe health issues, especially in children's case due to their immature nervous system. While realizing large-scale monitoring of children blood lead remains challenging by utilizing traditional methods, it is highly desirable to search for alternative techniques or novel sensing materials. Here we report a label-free and portable aptasensor based on graphene field effect transistor (FET) for effective children blood lead detection. With standard solutions of different Pb(2+) concentrations, we obtained a dose-response curve and a detection limitation below 37.5 ng/L, which is three orders lower than the safe blood lead level (100 μg/L). The devices also showed excellent selectivity over other metal cations such as, Na(+), K(+), Mg(2+), and Ca(2+), suggesting the capability of working in a complex sample matrix. We further successfully demonstrated the detection of Pb(2+) ions in real blood samples from children by using our aptasensors, and explored their potential applications for quantification. Our results underscore such graphene FET aptasensors for future applications on fast detection of heavy metal ions for health monitoring and disease diagnostics.
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