ArticleEndocrine research2016
Modeling vitamin D insufficiency and moderate deficiency in adult mice via dietary cholecalciferol restriction.
Article in Endocrine research, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 38 citations in OpenAlex.
- Vitamin D deficiency alters prostate epithelial differentiation and increases prostate cancer aggressiveness in ex vivo and in vivo models.bioRxiv : the preprint server for biology · 2026Article
- Timing of standard chow exposure determines the variability of mouse phenotypic outcomes and gut microbiota profile.Lab animal · 2025Article
- Impact of vitamin D on hyperoxic acute lung injury in neonatal mice.BMC pulmonary medicine · 2024Article
- Vitamin D Deficiency Does Not Affect Cognition and Neurogenesis in Adult C57Bl/6 Mice.Nutrients · 2024Article
- Experimental Vitamin D Deficiency in Rats: Clinical Chemistry, Histopathological, and Immunological Evaluation.Cureus · 2024Article
- Timing of standard chow exposure determines the variability of mouse phenotypic outcomes and gut microbiota profile.bioRxiv : the preprint server for biology · 2024Article
- Iron and vitamin D intake on a diet are able to modify the in vitro immune response to Mycobacterium leprae.Memorias do Instituto Oswaldo Cruz · 2024Article
- The role of the transsulfuration pathway in spermatogenesis of vitamin D deficient mice.Scientific reports · 2023Article
- Influence of Vitamin D Deficiency on Cyclin D1-Induced Parathyroid Tumorigenesis.Endocrinology · 2023Article
- Article
- Vitamin D modulates cortical transcriptome and behavioral phenotypes in an Mecp2 heterozygous Rett syndrome mouse model.Neurobiology of disease · 2022Article
- Impact of dietary vitamin D on immunoregulation and disease pathology in lupus-prone NZB/W F1 mice.Frontiers in immunology · 2022Article
- Co-administration of vitamin D3 andAnnals of microbiology · 2021Article
- Vitamin D deficiency and COVID-19.Clinical medicine (London, England) · 2020Article
- Bile acid composition regulates the manganese transporter Slc30a10 in intestine.The Journal of biological chemistry · 2020Article
- Oral Supplementation of the Vitamin D Metabolite 25(OH)DNutrients · 2020Article
- Vitamin D's Effect on Immune Function.Nutrients · 2020Review
- Effect of Chronic Vitamin D Deficiency on the Development and Severity of DSS-Induced Colon Cancer inComparative medicine · 2020Article
- Article
- Comparison of the effects of denosumab between a native vitamin D combination and an active vitamin D combination in patients with postmenopausal osteoporosis.Journal of bone and mineral metabolism · 2017Article
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
Abstract
purposeWe sought to develop and characterize a model of human vitamin D nutritional insufficiency/deficiency in the adult mouse, which could have broad utility in examining health consequences of this common condition.
methodsAdult mice were fed diets containing cholecalciferol contents of 0.05 IU/g, 0.25 IU/g, 0.5 IU/g or 1.5 IU/g for four months. We studied induction of steady-state vitamin D insufficiency, and its consequences on primary cholecalciferol metabolite levels, calcium homeostasis, parathyroid physiology, and bone morphology.
resultsAll diets were well tolerated, without adverse effects on body weight. Diets containing 0.05 IU/g and 0.25 IU/g cholecalciferol significantly lowered serum 25-hydroxyvitamin D levels (median 25OHD, 10.5 ng/ml, and 21.6 ng/ml, respectively), starting as early as one month following initiation of the diets, maintained through the four-month experimental period. The 0.05 IU/g diet significantly decreased 1,25-dihydroxyvitamin D (1,25OH
conclusionsThe dietary manipulations yielded states of vitamin D insufficiency or modest deficiency in adult mice, with no overtly detectable impact on parathyroid and bone physiology, and calcium homeostasis. This model system may be of value to study health effects of vitamin D insufficiency/deficiency especially on extraskeletal phenotypes such as cancer susceptibility or immune function.
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