Evidence map›Paper›PMID 26906106›Full record

ReviewClinical lymphoma, myeloma & leukemia2016

Role of Rituximab and Rituximab Biosimilars in Diffuse Large B-Cell Lymphoma.

Morton Coleman, Philip E Lammers, Fabio Ciceri, Ira A Jacobs

Open access · greenAbstract readReview
In one paragraph

Review in Clinical lymphoma, myeloma & leukemia, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
4.2field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 28 citations in OpenAlex.

  1. Article
  2. Article
  3. Post-genomic platform for development of oligonucleotide vaccines against RNA viruses: diamond cuts diamond.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2022
    Article
  4. Article
  5. Review
  6. Review
  7. Article
  8. Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 4 institutions in 2 countries.

Morton ColemanCenter for Lymphoma & Myeloma, Weill Cornell Medicine/New York-Presbyterian Hospital, New York, NY.
Philip E LammersDivision of Hematology/Oncology, Department of Internal Medicine, Meharry Medical College, Nashville, TN.
Fabio CiceriDivision of Hematology, University Vita-Salute San Raffaele IRCCS San Raffaele Scientific Institute, Milano, Italy.
Ira A JacobsGlobal Medical Affairs, Pfizer Inc, New York, NY. Electronic address: ira.jacobs@pfizer.com.
Istituto di Ricovero e Cura a Carattere Scientifico San RaffaeleMeharry Medical College · USNewYork–Presbyterian Hospital · USPfizer (United States) · US

Funding

Vanderbilt Clinical Oncology Research Career Development ProgramK12CA090625 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Debra L. Friedman, Paula Jill Hurley · 2001 to 2026
$16.9M
NCI NIH HHS K12 CA090625
6 · The paper itself

Abstract

Diffuse large B-cell lymphoma (DLBCL), an aggressive non-Hodgkin lymphoma (NHL), is the most-common subtype of NHL. DLBCL can be classified into at least 3 major immunologically distinct types, which contributes to considerable variation in disease prognosis and response to treatment. DLBCL potentially is curable, even when diagnosed at advanced stages. The current standard of care for most patients with untreated or relapsed/refractory DLBCL is chemoimmunotherapy containing rituximab, an anti-CD20 monoclonal antibody. With advanced understanding of the molecular mechanisms involved in the pathogenesis of DLBCL and specific signaling pathways that are activated in different subtypes, potential new therapeutic targets have been identified, some of which are at the late stages of clinical development. This review summarizes the critical role of rituximab in the current standard of care treatment for DLBCL and discusses why rituximab is likely to remain an important component of treatment options for DLBCL in the foreseeable future. In addition, current and emerging therapeutic agents, including potential benefits of rituximab biosimilars, for patients with DLBCL are discussed. The advent of rituximab biosimilars may facilitate accessibility of rituximab-based chemotherapies to patients with DLBCL and has potential cost-saving benefits for healthcare systems globally.

Indexed as

AdultAgedAntineoplastic AgentsBiosimilar PharmaceuticalsHumansImmunotherapyLymphoma, Large B-Cell, DiffuseMiddle AgedPrognosisRituximabAntineoplastic AgentsBiosimilar PharmaceuticalsRituximabAnti-CD20 monoclonal antibodyChemoimmunotherapyDLBCLNon–Hodgkin lymphomaR-CHOP

Identifiers

PMID26906106
PMCPMC10130787
OpenAlexW2272592620

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.